BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line.

abstract：:Whether alcohol-induced heart failure is caused by a direct toxic effect of ethanol, metabolites, or whether it is a secondary result of neurohumoral, hormonal, or nutritional factors is not clear. To address this question a Langendorff retrograde coronary perfusion model of rat heart was used to study the effect of 0...

journal_title：Biochemical and biophysical research communications

authors： Jänkälä H,Eklund KK,Kokkonen JO,Kovanen PT,Linstedt KA,Härkönen M,Mäki T

更新日期：2001-02-23 00:00:00

abstract：:In addition to the well established cyclooxygenase pathway, cultured aortic smooth muscle cells convert arachidonic acid to several polar metabolites identified by high performance liquid chromatography and gaz chromatography-mass spectrometry. 15-Hydroxyeicosatetraenoic acid, 12-Hydroxyeicosatetraenoic acid and 5-Hyd...

journal_title：Biochemical and biophysical research communications

authors： Larrue J,Rigaud M,Razaka G,Daret D,Demond-Henri J,Bricaud H

更新日期：1983-04-15 00:00:00

abstract：:Exploring the molecular mechanisms that regulate the osteogenesis of human mesenchymal stem cells (hMSCs) will bring us more efficient methods for improving the treatment of bone-related diseases. In this study, we analyzed the effects of miR-31 on the osteogenesis of hMSCs. The overexpression of miR-31 repressed the ...

journal_title：Biochemical and biophysical research communications

authors： Xie Q,Wang Z,Bi X,Zhou H,Wang Y,Gu P,Fan X

更新日期：2014-03-28 00:00:00

abstract：:Effects of various stresses were examined on the accumulation of mRNA for microsomal heme oxygenase and a heat shock protein, hsp70, in three human hepatoma cell lines. By heat shock, hsp70 mRNA was induced in all three hepatoma lines, Hep G2, Hep 3B and Hep G2f, while heme oxygenase mRNA was increased only in Hep 3B....

journal_title：Biochemical and biophysical research communications

authors： Mitani K,Fujita H,Sassa S,Kappas A

更新日期：1990-02-14 00:00:00

abstract：:Atriopeptin (AP) is synthesized and stored in the mammalian atria as a 126 amino acid prohormone (AP126). Upon secretion, the prohormone undergoes site specific proteolysis within the atria to yield the carboxyl terminal 28 amino acid hormone (AP28). The atrial cell responsible for AP126 bioactivation has not yet been...

journal_title：Biochemical and biophysical research communications

authors： Greenwald JE,Needleman P,Siegel N,Tetens E,Biel B,Ritter D

更新日期：1992-10-30 00:00:00

abstract：:We have previously reported the establishment of preadipocyte cell lines, termed dedifferentiated fat (DFAT) cells, from mature adipocytes of various animals. DFAT cells possess long-term viability and can redifferentiate into adipocytes both in vivo and in vitro. Furthermore, DFAT cells can transdifferentiate into os...

journal_title：Biochemical and biophysical research communications

authors： Kazama T,Fujie M,Endo T,Kano K

更新日期：2008-12-19 00:00:00

abstract：:Capsaicin, reported to elevate hormone sensitive lipase (HSL), is also found to inhibit the Ca++ and calmodulin-dependent cAMP phosphodiesterase (PDE) activity in adipose tissue of rats, fed high fat diet. The dependence of the enzyme activity on Ca++ and calmodulin in vitro, in control rats, is shown by its substanti...

journal_title：Biochemical and biophysical research communications

authors： Salimath BP,Satyanarayana MN

更新日期：1987-10-14 00:00:00

abstract：:We describe a method for the removal of endogenous troponin (Tn) complex from bundles of detergent-treated cardiac fibers. After 70 min treatment with cTnT-cTnI most of the endogenous Tn complex was removed from fiber bundles. Complete reconstitution of the Tn complex was achieved by reconstituting with cardiac tropon...

journal_title：Biochemical and biophysical research communications

authors： Chandra M,Kim JJ,Solaro RJ

更新日期：1999-09-16 00:00:00

abstract：:Actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on all-trans-retinoic acid (trans-RA) binding to retinoic acid receptors (RARs) in cultured human keratinocytes (SCC-12F) was investigated. TCDD and trans-RA elicited opposing actions on the production of biologically active TGF-beta. TCDD exposure caused concentra...

journal_title：Biochemical and biophysical research communications

authors： Lorick KL,Toscano DL,Toscano WA Jr

更新日期：1998-02-24 00:00:00

abstract：:The effects of insulin on the steady-state level of human insulin receptor (hIR) mRNA were examined in the HepG2 human liver cell line using Northern blot analysis of either total cellular or poly(A)+ RNA. In control cells, up to six (4.5, 5.2, 7.4, 8.5, 9.4 and 10.8 kb) hybridizable species of hIR mRNA were identifie...

journal_title：Biochemical and biophysical research communications

authors： Rohilla AM,Anderson C,Wood WM,Berhanu P

更新日期：1991-03-15 00:00:00

abstract：:Small heat-shock proteins (sHSPs) represent an abundant and ubiquitous family of molecular chaperones. The current model proposes that sHSPs function to prevent irreversible aggregation of non-native proteins by forming soluble complex. The chaperone activity of sHSPs is usually determined by the capacity to suppress ...

journal_title：Biochemical and biophysical research communications

authors： Jiao W,Li P,Zhang J,Zhang H,Chang Z

更新日期：2005-09-16 00:00:00

abstract：:Pulmonary fibrosis is a progressive disorder whose molecular pathology is poorly understood. Here we developed an in-house cDNA microarray ("lung chip") originating from a lung-normalized cDNA library. By using this lung chip, we analyzed global gene expression in a murine model of bleomycin-induced fibrosis and selec...

journal_title：Biochemical and biophysical research communications

authors： Katsuma S,Nishi K,Tanigawara K,Ikawa H,Shiojima S,Takagaki K,Kaminishi Y,Suzuki Y,Hirasawa A,Ohgi T,Yano J,Murakami Y,Tsujimoto G

更新日期：2001-11-09 00:00:00

abstract：:Based on the high level of identity among human, mouse, and rat MRP1 protein sequence, we produced a specific polyclonal antibody (MRP1-A23) against a synthetic polypeptide covering the C-terminus of the human protein. Western blot analysis showed a reactivity against human MRP1 similar to that obtained with the monoc...

journal_title：Biochemical and biophysical research communications

authors： Fernetti C,Pascolo L,Podda E,Gennaro R,Stebel M,Tiribelli C

更新日期：2001-11-09 00:00:00

abstract：:Injection of DN-BR mRNA encoding a dominant negative type I receptor for bone morphogenetic protein 4 (BMP4) converted prospective ectoderm into neural tissue in Xenopus animal cap explants, in the absence of expression of mesodermal marker genes. The injected caps expressed a general neural marker NCAM and the forebr...

journal_title：Biochemical and biophysical research communications

authors： Xu RH,Kim J,Taira M,Zhan S,Sredni D,Kung HF

更新日期：1995-07-06 00:00:00

abstract：:The present study demonstrates that human platelets possess a specific L-arginine transport system able to provide adequate amounts of L-arginine for endogenous nitric oxide production. L-arginine uptake takes place through a saturable high affinity carrier-mediated Na(+)-independent process which is significantly inh...

journal_title：Biochemical and biophysical research communications

authors： Vasta V,Meacci E,Farnararo M,Bruni P

更新日期：1995-01-26 00:00:00

abstract：:We have characterized the genomic structure of the mouse Zfp148 gene encoding Beta-Enolase Repressor Factor-1 (BERF-1), a Kruppel-like zinc finger protein involved in the transcriptional regulation of several genes, which is also termed ZBP-89, BFCOL1. The cloned Zfp148 gene spans 110 kb of genomic DNA encompassing th...

journal_title：Biochemical and biophysical research communications

authors： Feo S,Antona V,Cammarata G,Cavaleri F,Passantino R,Rubino P,Giallongo A

更新日期：2001-04-27 00:00:00

abstract：:Tetraheme cytochrome c3 (13 kDa) and flavodoxin (16 kDa), are small electron transfer proteins that have been used to mimic, in vitro, part of the electron-transfer chain that operates between substract electron donors and respiratory electron acceptors partners in Desulfovibrio species (Palma, N., Moura, I., LeGall, ...

journal_title：Biochemical and biophysical research communications

authors： Correia C,Monzani E,Moura I,Lampreia J,Moura JJ

更新日期：1999-03-16 00:00:00

abstract：:Although GPRC5B and GPRC5C are categorized into the G protein-coupled receptor family C, including glutamate receptors, GABA receptors, and taste receptors, their physiological functions remain unknown. Since both receptors are expressed in the brain and evolutionarily conserved from fly to human, it is conceivable th...

journal_title：Biochemical and biophysical research communications

authors： Sano T,Kim YJ,Oshima E,Shimizu C,Kiyonari H,Abe T,Higashi H,Yamada K,Hirabayashi Y

更新日期：2011-09-02 00:00:00

abstract：:Cloned murine mammary tumor virus (MuMTV) sequences allowed us to search for murine mammary tumor virus related sequences in the DNA of surgically removed human breast tumors. Out of 28 tumors so far examined two were found to contain an Eco RI DNA fragment homologous to the long terminal repeat-group antigen (LTR-Gag...

journal_title：Biochemical and biophysical research communications

authors： Crépin M,Lidereau R,Chermann JC,Pouillart P,Magdamenat H,Montagnier L

更新日期：1984-01-13 00:00:00

abstract：:Long-term glucocorticoid (GC) usage may cause non-traumatic femoral head osteonecrosis. Dexamethasone (Dex) is shown to exert potent cytotoxic effect to osteoblasts. Here, we investigated the potential activity of α-melanocyte stimulating hormone (α-MSH) against the process. Our data revealed that pretreatment of α-MS...

journal_title：Biochemical and biophysical research communications

authors： Guo S,Xie Y,Fan JB,Ji F,Wang S,Fei H

更新日期：2016-01-08 00:00:00

abstract：:Using both a 25 mM Lithium di-iodosalicylic acid (LIS) and a 2M NaCl extraction procedure to extract nuclear matrices from white cells we have identified a 0.9 kb nuclear matrix associated region (MAR) in the human pro alpha 2(I) collagen gene. The MAR is located towards the 3' coding end of the gene, it is completely...

journal_title：Biochemical and biophysical research communications

authors： Ellis GC,Grobler-Rabie AF,Hough FS,Bester AJ

更新日期：1988-12-15 00:00:00

abstract：:Tooth and bone are major tissues involved in physiological calcification in the body, and they use similar molecular pathways for development, homeostasis, and regeneration. Harmine (HMN) is a natural small compound that stimulates osteoblast differentiation in vitro and in vivo. Here we examined the biological effect...

journal_title：Biochemical and biophysical research communications

authors： Fujiwara N,Lee JW,Kumakami-Sakano M,Otsu K,Woo JT,Iseki S,Ota MS

更新日期：2018-03-11 00:00:00

abstract：:A synthetic peptide corresponding to the seven carboxy-terminal amino acids of tyrosine aminotransferase was coupled to ovalbumin or keyhole limpet haemocyanin, and the resulting conjugates were used to raise anti-peptide antibodies by immunization of rabbits. The crude sera were purified and tested for recognition of...

journal_title：Biochemical and biophysical research communications

authors： Dietrich JB,Genot G,Beck G

更新日期：1987-04-29 00:00:00

abstract：:In a chicken B cell line, DT40, the disruption of HDAC2 (chHDAC2) gene causes an alteration of several gene expressions including chicken IgM light chain (chIgM-L) gene by 2D-PAGE analysis. To investigate the transcriptional function of chHDAC2, we employed the chIgM-L promoter reporter plasmid. We found that chHDAC2 ...

journal_title：Biochemical and biophysical research communications

authors： Takechi S,Adachi M,Nakayama T

更新日期：2002-11-29 00:00:00

abstract：:The aim of this study was to understand the mechanism of action through which carnosine (beta-alanyl-L-histidine) acts as a quencher of cytotoxic alpha,beta-unsaturated aldehydes, using 4-hydroxy-trans-2,3-nonenal (HNE) as a model aldehyde. In phosphate buffer solution (pH 7.4), carnosine was 10 times more active as a...

journal_title：Biochemical and biophysical research communications

authors： Aldini G,Carini M,Beretta G,Bradamante S,Facino RM

更新日期：2002-11-15 00:00:00

abstract：:The domain(s) responsible for the specific heterophilic adhesion between two members of the carcinoembryonic antigen (CEA) family, CEACAM6 and CEACAM8, both of which with three extracellular domains, were investigated using Chinese hamster ovary (CHO) transfectants expressing chimeric antigens. Using a chimeric antige...

journal_title：Biochemical and biophysical research communications

authors： Oikawa S,Sugiyama M,Kuroki M,Kuroki M,Nakazato H

更新日期：2000-11-30 00:00:00

abstract：:Intracellular free calcium ([Ca2+]i) was measured in individual pancreatic beta-cells from mice using dual emission microfluorometry and the indicator Indo-1 applied by a patch clamp pipette. GTP-gamma-S (100 microM) injected together with 0.3 or 3 mM ATP evoked repetitive [Ca2+]i transients with a frequency of about ...

journal_title：Biochemical and biophysical research communications

authors： Lund PE,Grapengiesser E,Gylfe E,Hellman B

更新日期：1991-06-14 00:00:00

abstract：:The decomposition of peroxynitrite in the presence of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) generated 5,5-dimethylpyrrolidone-(2)-oxy-(1) (DMPOX) without formation of DMPO/OH. Formate enhanced the peroxynitrite decomposition but did not generate any detectable amount of formate-derived free radicals. Glutathione, cy...

journal_title：Biochemical and biophysical research communications

authors： Shi X,Lenhart A,Mao Y

更新日期：1994-09-30 00:00:00

abstract：:Previous investigations in our laboratory demonstrated the existence of an intrinsic mechanism, termed membrane modulation, capable of restoring sensitivity to aspirin treated platelets, resulting in irreversible aggregation in response to arachidonic acid (AA). The mechanism underlying correction of aspirin induced i...

journal_title：Biochemical and biophysical research communications

authors： Rao GH,Radha E,White JG

更新日期：1985-08-30 00:00:00

abstract：:The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted alpha-helix-turn-alpha-helix structures and two sequences each o...

journal_title：Biochemical and biophysical research communications

authors： Uchida K,Morita T,Sato T,Ogura T,Yamashita R,Noguchi S,Suzuki H,Nyunoya H,Miwa M,Sugimura T

更新日期：1987-10-29 00:00:00