The miR-599 promotes non-small cell lung cancer cell invasion via SATB2.

abstract：:Treatment of the cells of the 311 cell line, a pluripotent mouse teratocarcinoma cell line, with 12-O-tetradecanoylphorbol-13-acetate (TPA) modulates c-mos expression. Transient suppression of 6.1 and 4.6 kilobases (kb) transcripts and activation of 1.8 transcript indicate that TPA mediates concurrently positive and n...

journal_title：Biochemical and biophysical research communications

authors： Ogiso Y,Kitagawa K,Nishino H,Iwashima A

更新日期：1988-07-15 00:00:00

abstract：:We examined voltage-dependent, TTX-resistant Na+ channels of newt retina (nRNaCh) electrophysiologically. IC50-TTX value of nRNaCh is more than 20 microM. We determined partial cDNA sequences of nRNaCh restricted to TTX binding sites (SS2 regions of all four repeats). While the amino acid sequences of SS2 regions of r...

journal_title：Biochemical and biophysical research communications

authors： Kaneko Y,Matsumoto G,Hanyu Y

更新日期：1997-11-26 00:00:00

abstract：:Interleukin (IL)-33 is a novel member of the IL-1 family. IL-33 is primarily synthesized as a 30-kDa precursor (pro-IL-33). Pro-IL-33 is cleaved by caspase-1 into an 18-kDa mature form (mature IL-33) in vitro. Recombinant mature IL-33 has been known to induce T-helper type-2 (Th2)-associated cytokines and inflammatory...

journal_title：Biochemical and biophysical research communications

authors： Hayakawa M,Hayakawa H,Matsuyama Y,Tamemoto H,Okazaki H,Tominaga S

更新日期：2009-09-11 00:00:00

abstract：:The role of the cytoplasmic domain of human Fc gamma RII in cellular activation was studied by transfecting P815 cells with different isoforms or deletion mutants of this receptor and then assaying protein tyrosine phosphorylation after crosslinking with anti-CD32 monoclonal antibodies. Fc gamma RIIa, but not Fc gamma...

journal_title：Biochemical and biophysical research communications

authors： Liu Z,Pudiak D,Looney RJ

更新日期：1994-06-15 00:00:00

abstract：:Data on a new entity which inhibits the release of luteinizing hormone (LH), designated as factor C-LHIH, are presented. In vitro assays were carried out with pituitary glands from female rats. Factor C-LHIH and follicle stimulating hormone releasing hormone (FSHRH) initially fractionated together. FSHRH obscured C...

journal_title：Biochemical and biophysical research communications

authors： Johansson KN,Greibrokk T,Currie BL,Hansen J,Folkers K

更新日期：1975-03-03 00:00:00

abstract：:We previously identified the gene expression of renin-angiotensin system in human monocyte-derived dendritic cells (DCs). This study was conducted to examine the mechanisms by which angiotensin II and captopril, the inhibitor of the angiotensin-converting enzyme (ACE), affect human DCs. In DCs, lipopolysaccharide (LPS...

journal_title：Biochemical and biophysical research communications

authors： Lapteva N,Ide K,Nieda M,Ando Y,Hatta-Ohashi Y,Minami M,Dymshits G,Egawa K,Juji T,Tokunaga K

更新日期：2002-08-09 00:00:00

abstract：:Although Pol III promoters synthesize shRNA and elicit RNAi efficiently, however, a major limitation is that they are constitutively expressed in all cell types. To circumvent this problem, in the present study, we described a novel shRNA vector based on Pol II/T7 dual-promoter couple system: the transcription of shRN...

journal_title：Biochemical and biophysical research communications

authors： Peng Y,Lu JX,Shen XF

更新日期：2007-08-24 00:00:00

abstract：:The subunit arrangement of wheat germ RNA polymerase II was examined using the cleavable cross-linking reagent dithiobis(succinimidyl propionate). Conditions were chosen such that the enzyme was active prior to treatment, and that most of the subunits were reactive towards the reagent. Our results indicate that the en...

journal_title：Biochemical and biophysical research communications

authors： Bateman E,Nicholson BH

更新日期：1984-06-15 00:00:00

abstract：:Hereditary multiple exostoses (EXT) is an autosomal dominant disorder that is characterized by the appearance of multiple outgrowths of the long bones (exostoses) at their epiphyses. Genetical heterogeneities have segregated at least on chromosome 8, 11, and 19 and been designated EXT1, EXT2, and EXT3, respectively. R...

journal_title：Biochemical and biophysical research communications

authors： Saito T,Seki N,Yamauchi M,Tsuji S,Hayashi A,Kozuma S,Hori T

更新日期：1998-02-04 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19 (coronavirus disease-19), represents a far more serious threat to public health than SARS and MERS coronaviruses, due to its ability to spread more efficiently than its predecessors. Currently, there is no worldwide-approved ...

journal_title：Biochemical and biophysical research communications

authors： Santopolo S,Riccio A,Santoro MG

更新日期：2020-11-28 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) receptor agonists have been used to treat type 2 diabetic patients and shown to reduce food intake and body weight. The anorexigenic effects of GLP-1 and GLP-1 receptor agonists are thought to be mediated primarily via the hypothalamic paraventricular nucleus (PVN). GLP-1, an intestinal...

journal_title：Biochemical and biophysical research communications

authors： Katsurada K,Maejima Y,Nakata M,Kodaira M,Suyama S,Iwasaki Y,Kario K,Yada T

更新日期：2014-08-22 00:00:00

abstract：:Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset dominant genetic disease caused by the expansion of a GCG trinucleotide repeat that encodes the polyalanine tract at the N-terminus of the nuclear poly(A)-binding protein (PABPN1). Presence of intranuclear inclusions (INIs) containing PABPN1 aggregates in the...

journal_title：Biochemical and biophysical research communications

authors： Wang Q,Bag J

更新日期：2006-02-17 00:00:00

abstract：:The human amyloid beta protein (BP) is a major constituent of the amyloid deposited in the brain of patients with Alzheimer's disease and is derived from a larger precursor protein (BPP). In human three alternatively-spliced forms of BPP mRNA were found and two of them were shown to encode a protease inhibitory activi...

journal_title：Biochemical and biophysical research communications

authors： Yamada T,Sasaki H,Dohura K,Goto I,Sakaki Y

更新日期：1989-02-15 00:00:00

abstract：:The efficacy of gamma-guanidinooxypropylamine (GAPA), a novel agmatine analogue against protozoan parasite, Leishmaniadonovani was evaluated. Wild-type and ornithine decarboxylase-overexpressors of L. donovani were used to study the effect and mode of action of this inhibitor. GAPA inhibited the growth of both promast...

journal_title：Biochemical and biophysical research communications

authors： Singh S,Jhingran A,Sharma A,Simonian AR,Soininen P,Vepsalainen J,Khomutov AR,Madhubala R

更新日期：2008-10-10 00:00:00

abstract：:The exposure of organ cultured pineal glands of Syrian hamsters to forskolin, an adenylate cyclase activator, caused marked increases in serotonin N-acetyltransferase activity and melatonin content in a dose-related manner (1-100 microM) when glands were collected in the second half of the dark period. However, additi...

journal_title：Biochemical and biophysical research communications

authors： Santana C,Guerrero JM,Reiter RJ,Gonzalez-Brito A,Menendez-Pelaez A

更新日期：1988-08-30 00:00:00

abstract：:We have previously identified the region containing transcriptional enhancer in mouse immunoglobulin heavy chain (IgH) gene as an initiation region of DNA replication. The octamer sequence therein has been found to be essential for initiation of DNA replication as well as for transcription. Octamer-binding protein fam...

journal_title：Biochemical and biophysical research communications

authors： Ogawa N,Ariga H,Iguchi-Ariga SM

更新日期：1994-05-16 00:00:00

abstract：:We show that an autocrine system for calcitonin gene-related peptide (CGRP) exists in F9 teratocarcinoma cells. Synthesis of CGRP by F9 cells was demonstrated by measuring the peptide concentration in cells and medium and by determining specific mRNA in cells. During six days of culture, CGRP secretion did not vary si...

journal_title：Biochemical and biophysical research communications

authors： Segond N,Gerbaud P,Cressent M,Lasmoles F,Taboulet J,Jullienne A,Raynaud F,Moukhtar MS,Evain-Brion D

更新日期：1992-08-31 00:00:00

abstract：:Human erythrocyte acetylcholinesterase is an amphipathic enzyme whose hydrophobic membrane-binding domain can be selectively labeled with a lipophilic photoreagent and removed by digestion with papain. In this paper we demonstrate that methanolysis releases covalently bound fatty acids from the hydrophobic domain and ...

journal_title：Biochemical and biophysical research communications

authors： Roberts WL,Rosenberry TL

更新日期：1985-12-17 00:00:00

abstract：:Neurotensin (NT) is now classified as a brain-gut peptide in the central nervous system and gastrointestinal tract. In the present study, we characterized the NT receptors on the rat liver plasma membranes. The specific binding of [3H]NT was time dependent, reversible, and saturable. Scatchard analysis of the specific...

journal_title：Biochemical and biophysical research communications

authors： Muraki K,Nishi Y,Arai M,Kubo N,Ueda K,Shikata H,Nakata Y,Segawa T,Yanaihara N,Yajima H

更新日期：1987-06-30 00:00:00

abstract：:Genome-wide DNA hypomethylation is a critical mechanism underlying neoplastic transformation. Thus, genes that are suppressed in normal tissues or in specific cell types may become aberrantly expressed in neoplasia. To determine whether DNA methylation can modulate matrix metalloproteinase (mmp) gene expression, we ha...

journal_title：Biochemical and biophysical research communications

authors： Couillard J,Demers M,Lavoie G,St-Pierre Y

更新日期：2006-04-21 00:00:00

abstract：:Xenopus XmN-cadherin gene appears to have dual functions, since its mRNA is maternally provided in unfertilized eggs, once disappears almost completely during gastrula stage, then accumulates again specifically in neural tissues in later stage embryos. In the present experiment, we first followed the change in XmN-cad...

journal_title：Biochemical and biophysical research communications

authors： Hojyo T,Tooi O,Tashiro K,Shiokawa K

更新日期：1998-01-06 00:00:00

abstract：:The current utility of bioluminescence imaging is constrained by a low photon yield that limits temporal sensitivity. Here, we describe an imaging method that uses a chemiluminescent/fluorescent protein, ffLuc-cp156, which consists of a yellow variant of Aequorea GFP and firefly luciferase. We report an improvement in...

journal_title：Biochemical and biophysical research communications

authors： Hara-Miyauchi C,Tsuji O,Hanyu A,Okada S,Yasuda A,Fukano T,Akazawa C,Nakamura M,Imamura T,Matsuzaki Y,Okano HJ,Miyawaki A,Okano H

更新日期：2012-03-09 00:00:00

abstract：:Sarafotoxins (SRTXs) are endothelin-like peptides extracted from snake venom. SRTXs stimulate the endothelin ETA and ETB receptors and enhance vasoconstriction, followed by left ventricular dysfunction and bronchoconstriction. SRTXs include four major isopeptides, S6a-d, with different subtype selectivities. Here, we ...

journal_title：Biochemical and biophysical research communications

authors： Izume T,Miyauchi H,Shihoya W,Nureki O

更新日期：2020-07-23 00:00:00

abstract：:Angiotensin II (Ang II) and oxidized LDL (Ox-LDL) are risk factors for atherosclerosis, and both of them contribute to macrophage cholesterol accumulation, the hallmark of early atherosclerosis. As Ang II was shown to increase macrophage uptake of Ox-LDL, we investigated the effect of losartan, an Ang II receptor anta...

journal_title：Biochemical and biophysical research communications

authors： Hayek T,Aviram M,Heinrich R,Sakhnini E,Keidar S

更新日期：2000-07-05 00:00:00

abstract：:The Br140 protein was initially identified due to its co-purification with an integrin. We have cloned and sequenced the cDNA corresponding to the Br140 protein. Analysis of the amino acid sequence indicates that Br140 has features characteristic of gene regulatory proteins, including zinc fingers. Furthermore, Br140 ...

journal_title：Biochemical and biophysical research communications

authors： Thompson KA,Wang B,Argraves WS,Giancotti FG,Schranck DP,Ruoslahti E

更新日期：1994-02-15 00:00:00

abstract：:We have developed a charge-mediated fusion method to reconstitute the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in giant unilamellar vesicles (GUV). Intracellular Ca2+ transport by SERCA controls key processes in human cells such as proliferation, signaling, and contraction. Small-molecule effectors of SERCA are...

journal_title：Biochemical and biophysical research communications

authors： Bian T,Autry JM,Casemore D,Li J,Thomas DD,He G,Xing C

更新日期：2016-12-09 00:00:00

abstract：:Previously, we reported that CARM1 undergoes ubiquitination-dependent degradation in renal podocytes. It was also reported that CARM1 is necessary for fasting-induced hepatic gluconeogenesis. Based on these reports, we hypothesized that treatment with insulin, a hormone typically present under the 'fed' condition, wou...

journal_title：Biochemical and biophysical research communications

authors： Yeom CG,Kim DI,Park MJ,Choi JH,Jeong J,Wi A,Park W,Han HJ,Park SH

更新日期：2015-06-05 00:00:00

abstract：:Low density lipoprotein (LDL) is readily oxidized under certain conditions, resulting in the formation of oxidized LDL (oxLDL). Despite numerous in vitro reports that reveal the pathogenic role of oxidative stress, anti-oxidative strategies have underperformed in the clinic. In this study, we examine the role of oxLDL...

journal_title：Biochemical and biophysical research communications

authors： Kim OS,Lee CS,Joe EH,Jou I

更新日期：2006-03-31 00:00:00

abstract：:Pyruvate dehydrogenase kinase isoform 4 (PDK4) is upregulated by starvation in many tissues of the body during starvation. This causes inactivation of the pyruvate dehydrogenase complex which blocks pyruvate oxidation and conserves lactate and alanine for gluconeogenesis. Enhanced PDK4 expression may be caused by the ...

journal_title：Biochemical and biophysical research communications

authors： Wu P,Peters JM,Harris RA

更新日期：2001-09-21 00:00:00

abstract：:A stability map of local secondary structure of the mRNA of the triple-helical alpha 2(I) chain domain of chicken type I collagen was obtained by plotting the free energy of the optimal secondary structure of a local segment in mRNA against the segment position along a base sequence of the mRNA. It was found that the ...

journal_title：Biochemical and biophysical research communications

authors： Zama M

更新日期：1990-03-16 00:00:00