当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Activation and suppression of renin-angiotensin system in human dendritic cells.

Activation and suppression of renin-angiotensin system in human dendritic cells.

Abstract：

:We previously identified the gene expression of renin-angiotensin system in human monocyte-derived dendritic cells (DCs). This study was conducted to examine the mechanisms by which angiotensin II and captopril, the inhibitor of the angiotensin-converting enzyme (ACE), affect human DCs. In DCs, lipopolysaccharide (LPS)-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-(IL)-1alpha, IL-10, IL-12, and IL-18 was significantly inhibited by captopril. In contrast, angiotensin II treatment resulted in a significant increase in TNF-alpha and IL-6 protein biosynthesis by DCs. In addition, we have studied the global expression of 2400 genes in DCs from two donors. Here, we demonstrated the specific down-regulation of the ACE gene expression in captopril-treated DCs. Our finding indicates the possible activation of NF-kappaB through the up-regulation of expressions of MEFV gene (encoding PYRIN protein) and heterogeneous nuclear ribonucleoprotein R in DCs. This is the first study on the modulation of cytokine and gene expression by angiotensin II and captopril in DCs.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lapteva N,Ide K,Nieda M,Ando Y,Hatta-Ohashi Y,Minami M,Dymshits G,Egawa K,Juji T,Tokunaga K

doi

10.1016/s0006-291x(02)00855-0

subject

Has Abstract

pub_date

2002-08-09 00:00:00

pages

194-200

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X02008550

journal_volume

296

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • (2R,5R)-6-heptyne-2,5-diamine, an extremely potent inhibitor of mammalian ornithine decarboxylase.

    abstract：:It was previously shown that 5-hexyne-1,4-diamine is a potent enzyme-activated irreversible inhibitor of mammalian ornithine decarboxylase. However this compound has secondary pharmacological effects owing to its in vivo oxidation to 4-aminohex-5-ynoic acid, an irreversible inhibitor of 4-aminobutyrate aminotransferas...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)90406-0

    authors： Danzin C,Casara P,Claverie N,Metcalf BW,Jung MJ

    更新日期：1983-10-14 00:00:00

  • Demonstration of a basic fibroblast growth factor-like molecule in mouse hepatic endothelial cells.

    abstract：:We have investigated whether isolated mouse hepatic sinusoidal endothelial cells (HSEC) synthesized basic FGF. HSEC lysate was fractionated by heparin-Sepharose chromatography. A peak of mitogenic activity for Balb/c 3T3 fibroblasts was eluted with 3M NaCl. Several arguments suggested that the mitogenic factor was rel...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91782-8

    authors： Rosenbaum J,Mavier P,Preaux AM,Dhumeaux D

    更新日期：1989-11-15 00:00:00

  • Computer studies on the stereostructure and quantum chemical properties of 6-pyruvoyl tetrahydropterin, the key intermediate of tetrahydrobiopterin biosynthesis.

    abstract：:The optimized geometry of the conformation of atoms constituting the 6-pyruvoyl tetrahydropterin molecule, the labile key intermediate of tetrahydrobiopterin biosynthesis, was obtained by molecular orbital calculations within the MINDO/3 framework. The stereostructure of the molecule showing the preferred mode for bin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90888-e

    authors： Katoh S,Sueoka T,Kurihara T

    更新日期：1991-04-15 00:00:00

  • Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium.

    abstract：:Cadmium is a toxic metal present in the environment and its inhalation can lead to pulmonary disease such as lung cancer and chronic obstructive pulmonary disease. These lung diseases are characterized by chronic inflammation. Here we show that exposure of human airway epithelial cells to cadmium promotes a polarized ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.11.096

    authors： Rennolds J,Malireddy S,Hassan F,Tridandapani S,Parinandi N,Boyaka PN,Cormet-Boyaka E

    更新日期：2012-01-06 00:00:00

  • Synthesis and initial characterization of gamma-L-glutamyl-L-thiothreonylglycine and gamma-L-glutamyl-L-allo-thiothreonylglycine as steric probes of the active site of glyoxalase I.

    abstract：:The diastereomeric GSH derivatives gamma-L-Glu-L-allo-thioThr-Gly (6) and gamma-L-Glu-L-thioThr-Gly (6a) have been synthesized as specific probes of the steric environment near the cysteinyl residue of enzyme bound glutathionyl substrates. Experiments with glyoxalase I indicate that while 6a-methylglyoxal thiohemiacet...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91975-i

    authors： Xie XF,Creighton DJ

    更新日期：1991-05-31 00:00:00

  • Peroxiredoxin 1 is involved in disassembly of flagella and cilia.

    abstract：:Cilia/flagella are evolutionarily conserved cellular organelles. In this study, we demonstrated that Dunaliella salina Peroxiredoxin 1 (DsPrdx1) localized to the flagella and basal bodies, and was involved in flagellar disassembly. The link between DsPrdx1 and flagella of Dunaliella salina (D. salina) encouraged us to...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.01.081

    authors： Gong F,Liu H,Li J,Xue L,Zhang M

    更新日期：2014-02-14 00:00:00

  • Mutational analysis of the CitA citrate transporter from Salmonella typhimurium: altered substrate specificity.

    abstract：:The CitA citrate transporter in Salmonella typhimurium is encoded by the citA gene and consists of 434 amino acid residues that probably include 12 membrane-spanning segments [Shimamoto. T., et al. (1991) J. Biochem. 110, 22-28]. CitA mutants with altered substrate specificities were isolated by in vitro mutagenesis u...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1381

    authors： Shimamoto T,Negishi K,Tsuda M,Tsuchiya T

    更新日期：1996-09-13 00:00:00

  • Ubiquitin-specific protease 14 promotes prostate cancer progression through deubiquitinating the transcriptional factor ATF2.

    abstract：:Activating Transcription Factor 2 (ATF2) is a member of the ATF/CREB bZIP family of transcription factors and an oncogene in prostate cancer. ATF2 has been reported to be a critical substrate of the CUL3-SPOP-RBX1 E3 ubiquitin ligase complex and the recurrent somatic mutation of SPOP has been believed to be a key feat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.12.128

    authors： Geng L,Chen X,Zhang M,Luo Z

    更新日期：2020-03-26 00:00:00

  • Effects of hydrogen sulfide on homocysteine-induced oxidative stress in vascular smooth muscle cells.

    abstract：:Hydrogen sulfide (H(2)S) is an important gasotransmitter that generated in mammalian cells from l-cysteine metabolism. Little is known about its protective role in oxidative stress. In the present study, we investigated whether H(2)S could affect homocysteine (HCY)-induced cytotoxicity and oxidative stress in vascular...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.10.058

    authors： Yan SK,Chang T,Wang H,Wu L,Wang R,Meng QH

    更新日期：2006-12-15 00:00:00

  • Demonstration of a leptin binding factor in human serum.

    abstract：:Serum leptin levels are elevated in subjects with exogenous obesity, indicating that obesity is associated with leptin resistance. Since in man no abnormalities have yet been found in either the genes for leptin or its receptor, the mechanism of leptin resistance in obesity remains unknown. To determine if resistance ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6538

    authors： Diamond FB Jr,Eichler DC,Duckett G,Jorgensen EV,Shulman D,Root AW

    更新日期：1997-04-28 00:00:00

  • RETRACTED: Anti-angiogenic effect of Interleukin-26 in oxygen-induced retinopathy mice via inhibiting NFATc1-VEGF pathway.

    abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of authors. The Journal received an expression of concern from a reader, which noted that: “The problem is that there is no IL-26 gene in t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,收录出版

    doi：10.1016/j.bbrc.2018.04.004

    authors： Bao J,Lv Z,Wang S

    更新日期：2018-05-23 00:00:00

  • Is cAMP the obligatory second messenger in the action of lutropin on Leydig cell steroidogenesis.

    abstract：:Two adenylate cyclase inhibitors: 9-(tetrahydro-2-furyl)adenine and 2'5'-dideoxyadenosine decreased cAMP levels in LH-stimulated immature rat Leydig cells by 20-40%, independent of the concentration of LH. Steroid production was not correlated with this decrease in cAMP, but was increased (146%). The phorbol ester 4 b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91063-0

    authors： Themmen AP,Hoogerbrugge JW,Rommerts FF,van der Molen HJ

    更新日期：1985-05-16 00:00:00

  • A secondary structure prediction of the hemorrhagic metalloprotease family.

    abstract：:A secondary structure has been predicted for the hemorrhagic metalloproteases using a method developed in Zurich that extracts structural information from patterns of conservation and variation in homologous protein sequences. This prediction tests the limits of the method when applied to a small number of homologous ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1856

    authors： Gerloff DL,Jenny TF,Knecht LJ,Benner SA

    更新日期：1993-07-15 00:00:00

  • Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2.

    abstract：:The secreted isoform of fibroblast growth factor 3 (FGF3) induces a mitogenic cell response, while the nuclear form inhibits cell proliferation. Recently, we identified a nucleolar FGF3-binding protein which is implicated in processing of pre-rRNA as a possible target of nuclear FGF3 signalling. Here, we report a seco...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.10.079

    authors： Antoine M,Reimers K,Wirz W,Gressner AM,Müller R,Kiefer P

    更新日期：2005-12-16 00:00:00

  • Pharmacological and signaling analysis of human chemokine receptor CCR-7 stably expressed in HEK-293 cells: high-affinity binding of recombinant ligands MIP-3beta and SLC stimulates multiple signaling cascades.

    abstract：:The chemokine receptor CCR-7 is expressed in T, NK, and dendritic cells in a time-ordered and stimulus-dependent manner. Thorough analyses of the pharmacological profiles of the recombinant ligands for CCR-7, MIP-3beta/ELC/CK-beta 11, and SLC/Exodus-2/TCA4/6C-kine, using CCR-7-expressing HEK-293E transfectants determi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1442

    authors： Sullivan SK,McGrath DA,Grigoriadis D,Bacon KB

    更新日期：1999-10-05 00:00:00

  • Stanniocalcin 1 binds hemin through a partially conserved heme regulatory motif.

    abstract：:Hemin (iron protoporphyrin IX) is a necessary component of many proteins, functioning either as a cofactor or an intracellular messenger. Hemoproteins have diverse functions, such as transportation of gases, gas detection, chemical catalysis and electron transfer. Stanniocalcin 1 (STC1) is a protein involved in respir...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.05.002

    authors： Westberg JA,Jiang J,Andersson LC

    更新日期：2011-06-03 00:00:00

  • Transverse motion of spin-labeled 3,3',5-triiodo-L-thyronine in phospholipid bilayers.

    abstract：:Using electron spin resonance stop-flow technique, the transverse motion (flip-flop) of 3-([alpha-carboxy-4-(4-hydroxy-3-iodophenoxy)-3,5- diiodophenethyl]carbamoyl)-2,2,5,5-tetramethyl-3-pyrrolin (T3-SL) in dipalmitoyl L-alpha-phosphosphatidylcholine (DPPC) membranes was evaluated. At 22 degrees C, the electron spin ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91817-0

    authors： Lai CS,Korytowski W,Niu CH,Cheng SY

    更新日期：1985-08-30 00:00:00

  • SDF-1alpha-induced intracellular calcium transient involves Rho GTPase signalling and is required for migration of hematopoietic progenitor cells.

    abstract：:Signalling through the chemokine stromal derived factor (SDF)-1alpha and its receptor CXCR4 has been recognized as a key event in the migratory response of hematopoietic stem and progenitor cells (HPC). Small GTPases of the Rho/Rac family might be involved in SDF-1alpha signalling at several different levels. In the p...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.10.112

    authors： Henschler R,Piiper A,Bistrian R,Möbest D

    更新日期：2003-11-28 00:00:00

  • UDP-GalNAc:NeuAc alpha 2,3Gal beta-R (GalNAc to Gal) beta 1,4-N-acetylgalactosaminyltransferase responsible for the Sda specificity in human colon carcinoma CaCo-2 cell line.

    abstract：:The UDP-GalNAc:NeuAc alpha 2,3Gal beta-R (GalNAc to Gal) beta-1,4-N-acetylgalactosaminyltransferase (beta 1,4GalNAc-transferase) is the enzyme responsible for the addition of the immunodominant sugar of the Sda isto-blood group determinant. In humans the enzyme is mainly expressed in the large intestine. We screened n...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81119-2

    authors： Malagolini N,Dall'Olio F,Serafini-Cessi F

    更新日期：1991-10-31 00:00:00

  • Monoclonal antibody-directed immunopurification and identification of cytochromes P-450.

    abstract：:Several rat liver cytochromes P-450 have been substantially purified in a one-step immunoadsorption procedure using Sepharose-bound monoclonal antibodies (MAbs) to the major forms of rat liver cytochrome P-450 induced by 3-methylcholanthrene and phenobarbital (MC-P-450 and PB-P-450, respectively). When mixed with solu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(83)80221-6

    authors： Friedman FK,Robinson RC,Park SS,Gelboin HV

    更新日期：1983-11-15 00:00:00

  • The vWFA2 domain of type VII collagen is responsible for collagen binding.

    abstract：:Type VII collagen (Col7) is the major component of anchoring fibrils and very important for skin integrity. This is emphasized by the Col7 related skin blistering diseases dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita. Structural data that provides insights into the interaction network of Col7 a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.11.119

    authors： Wegener H,Leineweber S,Seeger K

    更新日期：2013-01-11 00:00:00

  • Transforming growth factor-beta1 induces matrix metalloproteinase-9 expression in human meningeal cells via ERK and Smad pathways.

    abstract：:Transforming growth factor (TGF)-beta1, a cytokine released into the cerebrospinal fluid (CSF) after intraventricular hemorrhage (IVH), stimulates the expression of the components of the extracellular matrix (ECM), which causes progressive ventricular dilatation by impaired CSF absorption. Matrix metalloproteinase-9 (...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.04.038

    authors： Okamoto T,Takahashi S,Nakamura E,Nagaya K,Hayashi T,Fujieda K

    更新日期：2009-06-12 00:00:00

  • Stretching mesangial cells stimulates tyrosine phosphorylation of focal adhesion kinase pp125FAK.

    abstract：:Mechanical loading of cultured mesangial cells has been shown to induce both increased production of matrix proteins and cell proliferation. This in vitro phenomenon has been implicated in the progression of glomerular sclerosis observed in a variety of glomerular diseases. However, it is not yet known how cells sense...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2004

    authors： Hamasaki K,Mimura T,Furuya H,Morino N,Yamazaki T,Komuro I,Yazaki Y,Nojima Y

    更新日期：1995-07-17 00:00:00

  • TLR4 activates NF-κB in human ovarian granulosa tumor cells.

    abstract：:Previous studies have demonstrated expression of Toll-like receptors (TLRs) in the surface epithelium of normal ovaries (OSE) and in epithelial ovarian tumors. Most notably, OSE-derived cancers express TLR4, which activates the nuclear factor-kappa B (NF-κB) signaling cascade as a mediator of inflammatory response. Cu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.05.063

    authors： Woods DC,White YA,Dau C,Johnson AL

    更新日期：2011-06-17 00:00:00

  • Analysis of eighteen deletion breakpoints in the parkin gene.

    abstract：:Parkin mutations are responsible for the pathogenesis of autosomal-recessive juvenile parkinsonism (AR-JP). On initial screening of Japanese patients with AR-JP, we had found that approximately half of the parkin mutations are deletions occurring between exons 2 and 5, forming a deletion hot spot. In this study, we in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.08.115

    authors： Asakawa S,Hattori N,Shimizu A,Shimizu Y,Minoshima S,Mizuno Y,Shimizu N

    更新日期：2009-11-06 00:00:00

  • Key amino acids for differential coupling of alpha1-adrenergic receptor subtypes to Gs.

    abstract：:We have established that differing effects of alpha1-adrenergic receptor (AR) subtypes on cell proliferation are due to differential coupling to the Gs/cAMP pathway; thus, both alpha1A- and alpha1B-ARs couple to Gs, while alpha1D-AR does not. To identify the region responsible for this difference in subtype-specific G...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02589-5

    authors： Shinoura H,Shibata K,Hirasawa A,Tanoue A,Hashimoto K,Tsujimoto G

    更新日期：2002-11-22 00:00:00

  • C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain.

    abstract：:Two types of natriuretic peptide, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), very similar to each other in structure and in pharmacological effect, are known to be present in mammalian heart and brain. In our present survey for unidentified peptides in porcine brain extracts, we found a new ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)92401-k

    authors： Sudoh T,Minamino N,Kangawa K,Matsuo H

    更新日期：1990-04-30 00:00:00

  • Identification of structural domains affecting transactivation potential of Nm23.

    abstract：:The strong transactivation activity of the C-terminal half (amino acids 76-152) of Nm23 was reported previously. Here we examined a structural domain preventing or necessary to its transactivation activity. The C-terminal 1/4 (amino acids 109-152) was sufficient for transactivation, but the C-terminal half with a long...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.6042

    authors： Cho SJ,Lee NS,Jung YS,Lee H,Lee KJ,Kim E,Chae SK

    更新日期：2001-12-07 00:00:00

  • Altered localization of amyloid precursor protein under endoplasmic reticulum stress.

    abstract：:Recent reports have shown that the endoplasmic reticulum (ER) stress is relevant to the pathogenesis of Alzheimer disease. Following the amyloid cascade hypothesis, we therefore attempted to investigate the effects of ER stress on amyloid-beta peptide (Abeta) generation. In this study, we found that ER stress altered ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.03.173

    authors： Kudo T,Okumura M,Imaizumi K,Araki W,Morihara T,Tanimukai H,Kamagata E,Tabuchi N,Kimura R,Kanayama D,Fukumori A,Tagami S,Okochi M,Kubo M,Tanii H,Tohyama M,Tabira T,Takeda M

    更新日期：2006-06-02 00:00:00

  • Peptide growth factors markedly decrease the ligand binding of angiotensin II type 2 receptor in rat cultured vascular smooth muscle cells.

    abstract：:Of two major isoforms of angiotensin II receptors, AT1 and AT2, biological roles of AT2 remain unclear. Using vascular smooth muscle cells, we investigated the regulation of expression of AT2 by growth factors in comparison with that of AT1. The cultured rat aorta smooth muscle cells had detectable AT2 binding sites, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1844

    authors： Kambayashi Y,Bardhan S,Inagami T

    更新日期：1993-07-15 00:00:00