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Demonstration of a basic fibroblast growth factor-like molecule in mouse hepatic endothelial cells.

Abstract：

:We have investigated whether isolated mouse hepatic sinusoidal endothelial cells (HSEC) synthesized basic FGF. HSEC lysate was fractionated by heparin-Sepharose chromatography. A peak of mitogenic activity for Balb/c 3T3 fibroblasts was eluted with 3M NaCl. Several arguments suggested that the mitogenic factor was related to bFGF: a) its affinity for heparin; b) the loss of its mitogenic activity by heating at 65 degrees C, which was prevented in the presence of heparin; c) the abolition of its mitogenic activity in the presence of protamine sulfate; d) finally, its mitogenic effect was reduced in the presence of antibody to bFGF. These data demonstrate the presence of a bFGF-like molecule in HSEC. This molecule could be involved in the regulation of the neighboring Ito cell proliferation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Rosenbaum J,Mavier P,Preaux AM,Dhumeaux D

doi

10.1016/0006-291x(89)91782-8

subject

Has Abstract

pub_date

1989-11-15 00:00:00

pages

1099-104

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91782-8

journal_volume

164

pub_type

杂志文章

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