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Sequence-constructive SELEX: a new strategy for screening DNA aptamer binding to Globo H.

Abstract：

:We proposed to use a novel stepwise sequence-constructive SELEX method to develop DNA aptamers that can recognize Globo H which is a tumor-associated carbohydrate antigen. A combinatorial synthetic library that consisted of DNA molecules with randomized regions of 15-bases was used as the starting library for the first SELEX procedure. The input DNA library for the second round of SELEX consisted of the extension of the 5' and 3'-ends with 7-bases that were randomized from four selected aptamers. The third round of SELEX was performed following the same procedures as described for the second round of SELEX. The experimental results indicate that the binding affinity of DNA aptamers to Globo H was enhanced when using the sequence-constructive SELEX approach. The selectivity of the DNA aptamers for related disaccharides, mannose derivatives, and Globo H analogs demonstrated the ability of the DNA aptamers to discriminate the presence of various glycans with different structures.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wang CY,Wu CY,Hung TC,Wong CH,Chen CH

doi

10.1016/j.bbrc.2014.08.086

subject

Has Abstract

pub_date

2014-09-26 00:00:00

pages

484-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(14)01509-5

journal_volume

452

pub_type

杂志文章

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