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Forskolin and prostacyclin inhibit fluoride induced platelet activation and protein kinase C dependent responses.

Abstract：

:Platelet activation (cytosolic [Ca2+] increase, aggregation and ATP secretion) was induced with A1F-4. This agent presumably interacts with a G protein which appears to mediate the coupling of the receptors for Ca mobilizing hormones and phospholipase C. All the A1F-4 evoked responses were inhibited by treatment with forskolin or prostacyclin, agents known to increase cellular cAMP. Thus the G protein-phospholipase C system appears to be the site of cAMP inhibition. Unexpectedly forskolin and prostacyclin also inhibited secretion and aggregation induced by the activators of protein kinase C, diglyceride and phorbol ester, suggesting that cAMP can also inhibit directly the protein kinase C dependent responses.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Doni MG,Deana R,Bertoncello S,Zoccarato F,Alexandre A

doi

10.1016/s0006-291x(88)80776-9

subject

Has Abstract

pub_date

1988-11-15 00:00:00

pages

1316-23

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80776-9

journal_volume

156

pub_type

杂志文章

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