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Homologous recombination in bovine papillomavirus shuttlevecter; effect of relative orientation of substrate sequences.

Abstract：

:Relative orientation of recombination substrates, neo gene, strongly influenced homologous recombination events in a bovine papillomavirus shuttle vector. Between direct repeats, recombination occurred at a high frequency while between inverted repeats, it was rare. Double strand break near the mutation site increased the recombination frequency between inverted repeats but not between direct repeats. Formation of long heteroduplex as a recombination intermediate may explain this apparently paradoxical phenomenon.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Naito A,Kitamura Y,Yoshikura H

doi

10.1016/0006-291x(91)90521-8

subject

Has Abstract

pub_date

1991-01-15 00:00:00

pages

305-12

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)90521-8

journal_volume

174

pub_type

杂志文章

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