Calmodulin and protein kinase C antagonists also inhibit the Ca2+-dependent protein protease, calpain I.

abstract：:Vasodilator-stimulated phosphoprotein (VASP) is an actin regulatory protein that functions in adhesion and migration. In epithelial cells, VASP participates in cell-cell adhesion. At the molecular level, VASP drives actin bundling and polymerization. VASP activity is primarily regulated by phosphorylation. Three physi...

journal_title：Biochemical and biophysical research communications

authors： Thomson DM,Ascione MP,Grange J,Nelson C,Hansen MD

更新日期：2011-10-14 00:00:00

abstract：:Interleukin 6 is a cytokine with growth and differentiation activities on a number of cell types. Human articular chondrocytes produce interleukin 6 and this production appears to be constitutive but can be stimulated in a dose-dependent manner by interleukin 1. Other stimulators of interleukin 6 production in chondro...

journal_title：Biochemical and biophysical research communications

authors： Bunning RA,Russell RG,Van Damme J

更新日期：1990-02-14 00:00:00

abstract：:Rap1GAP (for Rap1 GTPase Activating Protein) is an 89 kD protein that highly stimulates the intrinsic GTPase activity of the small GTP binding protein Rap1. It has been shown that Rap1GAP is phosphorylated in vitro by purified p34cdc2 kinase, which regulates the G2/M transition of the cell cycle. In this work, we have...

journal_title：Biochemical and biophysical research communications

authors： Janoueix-Lerosey I,Fontenay M,Tobelem G,Tavitian A,Polakis P,de Gunzburg J

更新日期：1994-07-29 00:00:00

abstract：:A potent analog (HNG) of the endogenous peptide humanin protects against myocardial ischemia-reperfusion (MI-R) injury in vivo, decreasing infarct size and improving cardiac function. Since oxidative stress contributes to the damage from MI-R we tested the hypotheses that: (1) HNG offers cardioprotection through activ...

journal_title：Biochemical and biophysical research communications

authors： Klein LE,Cui L,Gong Z,Su K,Muzumdar R

更新日期：2013-10-18 00:00:00

abstract：:T-type Ca(2+) channels have been implicated in tremorogenesis and motor coordination. The α1 subunit of the Ca(V)3.1 T-type Ca(2+) channel is highly expressed in motor pathways in the brain, but knockout of the Ca(V)3.1 gene (α(1G)(-/-)) per se causes no motor defects in mice. Thus, the role of Ca(V)3.1 channels in mo...

journal_title：Biochemical and biophysical research communications

authors： Chang KY,Park YG,Park HY,Homanics GE,Kim J,Kim D

更新日期：2011-06-24 00:00:00

abstract：:Neuromedin K and neuromedin L are novel mammalian tachykinins isolated from porcine spinal cord. We have developed a highly sensitive radioimmunoassay for neuromedin K. Since the radioimmunoassay for neuromedin K has significant crossreactivity with neuromedin L and substance P, we can simultaneously determine the tis...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Masuda H,Kangawa K,Matsuo H

更新日期：1984-11-14 00:00:00

abstract：:Bacteria belonging to the Burkholderia cepacia complex (BCC) are important opportunistic pathogens in patients with cystic fibrosis (CF). Since approximately 80% of the CF isolates examined produce exopolysaccharide (EPS), it was hypothesized that this EPS may play a role in the colonization and persistence of these b...

journal_title：Biochemical and biophysical research communications

authors： Moreira LM,Videira PA,Sousa SA,Leitão JH,Cunha MV,Sá-Correia I

更新日期：2003-12-12 00:00:00

abstract：:The fluorescence decay of adenosine in 1:1 glycol/water glass has been determined at 77K using narrow pulse (700 ps) laser excitation at 290 nm and fluorescence detection with a scanned narrow-gate (100 ps) fast sampler together with digital averaging. Data analysis by re-iterative non-linear least squares convolution...

journal_title：Biochemical and biophysical research communications

authors： Hart LP,Daniels M

更新日期：1989-07-31 00:00:00

abstract：:A Cl- channel protein of sarcoplasmic reticulum (SR) was purified by assaying the channel activity in a planar lipid bilayer system. The light fraction of SR vesicles was solubilized in CHAPS and fractioned by anion exchange, gel filtration, and affinity chromatography with concanavalin A. All fractions in each step w...

journal_title：Biochemical and biophysical research communications

authors： Ide T,Sakamoto H,Morita T,Taguchi T,Kasai M

更新日期：1991-04-15 00:00:00

abstract：:Recent works have shown that mechanical loading can alter the metabolic activity of chondrocytes cultured in 3D scaffolds. In this study we determined whether the stage of development of engineered cartilaginous constructs (expanded adult human articular chondrocytes/Polyactive foams) regulates the effect of dynamic c...

journal_title：Biochemical and biophysical research communications

authors： Démarteau O,Wendt D,Braccini A,Jakob M,Schäfer D,Heberer M,Martin I

更新日期：2003-10-17 00:00:00

abstract：:This study examined whether oral administration of an arginase inhibitor regulates adipose tissue macrophage infiltration and inflammation in mice with high fat diet (HFD)-induced obesity. Male C57BL/6 mice (n = 30) were randomly assigned to control (CTL, n = 10), HFD only (n = 10), and HFD with arginase inhibitor N(ω...

journal_title：Biochemical and biophysical research communications

authors： Hu H,Moon J,Chung JH,Kim OY,Yu R,Shin MJ

更新日期：2015-08-28 00:00:00

abstract：:In this study, we report the effect of endothelial progenitor cells (EPCs) on the biological behavior of osteoclast precursors in vitro by establishing an indirect co-culture system of mice EPCs and RAW 264.7 monocyte cells. Results show that the survival, migration, and differentiation of osteoclast precursors were g...

journal_title：Biochemical and biophysical research communications

authors： Pang H,Wu XH,Fu SL,Luo F,Zhang ZH,Hou TY,Li ZQ,Chang ZQ,Yu B,Xu JZ

更新日期：2013-01-11 00:00:00

abstract：:The effect of lipopolysaccharide (LPS) on the cell death induced by endoplasmic reticulum (ER) stress agents in RAW 264.7 cells was studied. LPS prevented the cell death by brefeldin A, but not thapsigargin and tunicamycin. CpG DNA as well as LPS prevented brefeldin A-induced cell death whereas tumor necrosis factor-a...

journal_title：Biochemical and biophysical research communications

authors： Islam S,Hassan F,Tumurkhuu G,Ito H,Koide N,Mori I,Yoshida T,Yokochi T

更新日期：2006-02-10 00:00:00

abstract：:Integrin LFA-1 regulates immune cell adhesion and trafficking by binding to ICAM-1 upon chemokine stimulation. Integrin-mediated clutch formation between extracellular ICAM-1 and the intracellular actin cytoskeleton is important for cell adhesion. We applied single-molecule tracking analysis to LFA-1 and ICAM-1 in liv...

journal_title：Biochemical and biophysical research communications

authors： Ishibashi M,Miyanaga Y,Matsuoka S,Kozuka J,Togashi Y,Kinashi T,Ueda M

更新日期：2015-08-21 00:00:00

abstract：:The induction of human BiP/GRP78 and GAPDH protein genes by the calcium ionophore A23187 was determined. Steady-state levels of mRNA for both the glucose starvation-responsive BiP/GRP78 gene and the glucose-responsive GAPDH gene were dramatically induced in a variety of human cells. There is a homologous palindromatic...

journal_title：Biochemical and biophysical research communications

authors： Chao CC,Yam WC,Lin-Chao S

更新日期：1990-08-31 00:00:00

abstract：:The ability to prevent methylene blue (MB), a photosensitizer, from being reduced by plasma reductases will greatly improve its efficacy in photodynamic therapy (PDT) applications. We have developed a delivery approach for PDT by encapsulating MB using nanoparticle platforms (NPs). The 30-nm polyacrylamide-based NPs p...

journal_title：Biochemical and biophysical research communications

authors： Tang W,Xu H,Park EJ,Philbert MA,Kopelman R

更新日期：2008-05-02 00:00:00

abstract：:The intrinsic GTPase activity of cellular protein p21ras is strongly increased by cytosolic GTPase activating protein (GAP). The activity of this enzyme has been shown to be inhibited by arachidonic acid. We report here that this inhibition is antagonized by the presence of 1-stearoyl, 2-arachidonoyl glycerol. This ef...

journal_title：Biochemical and biophysical research communications

authors： Homayoun P,Stacey DW

更新日期：1993-08-16 00:00:00

abstract：:Ribosome modulation factor (RMF) is involved in stabilization of ribosomes during the transition from exponential growth to the stationary growth phase in Escherichia coli. A deficiency of RMF is known to reduce cell viability. Overaccumulation of spermidine also leads to a decrease in cell viability and to a decrease...

journal_title：Biochemical and biophysical research communications

authors： Apirakaramwong A,Fukuchi J,Kashiwagi K,Kakinuma Y,Ito E,Ishihama A,Igarashi K

更新日期：1998-10-20 00:00:00

abstract：:p202, an interferon (IFN) inducible protein, is a phosphonuclear protein involved in the regulation of cell cycle, apoptosis, and differentiation. E2F1 belongs to the E2F family of proteins that are important cell cycle regulators in promoting cell growth. On the other hand, the deregulated expression of E2F1 also tri...

journal_title：Biochemical and biophysical research communications

authors： Yan DH,Abramian A,Li Z,Ding Y,Wen Y,Liu TJ,Hunt K

更新日期：2003-03-28 00:00:00

abstract：:For a series of adenosine analogues a close correlation (r = 0.986) was found between their antiviral potency (against vesicular stomatitis virus) and their inhibitory effects (Ki/Km) on S-adenosylhomocysteine (AdoHcy) hydrolase; thus, in order of increasing inhibitory potency for both virus replication and AdoHcy hyd...

journal_title：Biochemical and biophysical research communications

authors： De Clercq E,Cools M

更新日期：1985-05-31 00:00:00

abstract：:Using PAGE--Autoradioblotting technique we have characterized an E--FABP in human epidermal cells that is distinct from liver-, heart-, intestine- and adipose tissue-FABPs. FABP radiobinding analysis was performed directly on protein extracts without prior partial purification. E-FABP has a Mr of approximately 15 kDa ...

journal_title：Biochemical and biophysical research communications

authors： Siegenthaler G,Hotz R,Chatellard-Gruaz D,Jaconi S,Saurat JH

更新日期：1993-01-29 00:00:00

abstract：:Keap1 is proposed to be a sensor protein of electrophilic compounds and a transducer of the signal from electrophilic compounds for transcriptional activation. Thus, the use of keap1 gene-knockout (KO) mice is a straightforward approach in order to clarify the molecular background for the use of electrophilies as neur...

journal_title：Biochemical and biophysical research communications

authors： Satoh T,Harada N,Hosoya T,Tohyama K,Yamamoto M,Itoh K

更新日期：2009-03-06 00:00:00

abstract：:Previous genetic evidence led to the conclusion that proteinase B of yeast was not involved in the function of chitin synthetase 1 (Chs1), based on the demonstration of normal septum formation, cell division and chitin deposition in mutants devoid of the proteinase (Zubenko, G.S., Mitchell, A.P., and Jones, E.W. (1979...

journal_title：Biochemical and biophysical research communications

authors： Silverman SJ,Shaw JA,Cabib E

更新日期：1991-01-15 00:00:00

abstract：:Suppressor of cytokine signaling (SOCS) 1 was initially identified as an intracellular negative feedback regulator of the JAK-STAT signal pathway. Recently, it has been suggested that SOCS1 affects signals of growth factors and hormones. One of them, SOCS1, is also known to be involved in auto-regulation of IRS-1-medi...

journal_title：Biochemical and biophysical research communications

authors： Inaba M,Saito H,Fujimoto M,Sumitani S,Ohkawara T,Tanaka T,Kouhara H,Kasayama S,Kawase I,Kishimoto T,Naka T

更新日期：2005-03-25 00:00:00

abstract：:We recently demonstrated that metallothionein (MT)-1 A is a direct target gene negatively regulated by PU.1. In this study, we revealed that the expression of PU.1 was increased and accompanied by downregulation of MT-1A expression during TPA-induced THP-1 monocyte differentiation. Chromatin immunoprecipitation (ChIP)...

journal_title：Biochemical and biophysical research communications

authors： Suzuki S,Nakano H,Takahashi S

更新日期：2013-04-12 00:00:00

abstract：:Recent years have seen considerable evolution in our understanding of the mechanisms of oxygen activation by non-heme iron enzymes, with high-valent iron-oxo intermediates coming to the forefront as formidably potent oxidants. In the absence of substrate, the generation of vividly colored chromophores deriving from th...

journal_title：Biochemical and biophysical research communications

authors： Farquhar ER,Koehntop KD,Emerson JP,Que L Jr

更新日期：2005-12-09 00:00:00

abstract：:The process of endochondral ossification is strictly regulated by a variety of extracellular and intracellular factors. Recently, it has become recognized that specific miRNAs are involved in this process by regulating the expression of the relevant genes at the post-transcriptional level. In this present study we obt...

journal_title：Biochemical and biophysical research communications

authors： Sumiyoshi K,Kubota S,Ohgawara T,Kawata K,Nishida T,Shimo T,Yamashiro T,Takigawa M

更新日期：2010-11-12 00:00:00

abstract：:Calcineurin is a Ca2+ calmodulin dependent protein phosphatase which has an important role in the control of intracellular Ca2+ signalling. The protein is a heterodimer of one catalytic (CnA) subunit and one regulatory (CnB) subunit. As suggested by the protein sequence and confirmed by the crystallographic structure,...

journal_title：Biochemical and biophysical research communications

authors： Guerini D

更新日期：1997-06-18 00:00:00

abstract：:Stefin B is the major general cytosolic protein inhibitor of cysteine cathepsins. Its main function is to protect the organism against the activity of endogenous potentially hazardous proteases accidentally released from lysosomes. In this study, we investigated the possible effect of endosomal/lysosomal aspartic cath...

journal_title：Biochemical and biophysical research communications

authors： Železnik TZ,Kadin A,Turk V,Dolenc I

更新日期：2015-09-18 00:00:00

abstract：:Multidrug resistance (MDR) cells can be sensitized to anticancer drugs when treated concomitantly with chemosensitizers. In this study, chemosensitizing effects of 5,6,7,3',4'-pentamethoxyflavone (sinensetin) and its analogs were investigated with respect to in vitro efficacy and structure-activity relationship. Sinen...

journal_title：Biochemical and biophysical research communications

authors： Choi CH,Sun KH,An CS,Yoo JC,Hahm KS,Lee IH,Sohng JK,Kim YC

更新日期：2002-07-26 00:00:00