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Epigenetic regulation of the metallothionein-1A promoter by PU.1 during differentiation of THP-1 cells.

Abstract：

:We recently demonstrated that metallothionein (MT)-1 A is a direct target gene negatively regulated by PU.1. In this study, we revealed that the expression of PU.1 was increased and accompanied by downregulation of MT-1A expression during TPA-induced THP-1 monocyte differentiation. Chromatin immunoprecipitation (ChIP) analysis demonstrated that PU.1 and the methyl CpG binding protein (MeCP) 2 bound to the same -887 to -602 region in the MT-1A promoter, and the binding of these proteins to this promoter was enhanced during differentiation. Consistently, bisulfite sequencing analyses around this region revealed that the proportion of methylated CpG sites was obivously increased during differentiation. In addition, ChIP analysis demonstrated that acetylated histone H4 around this region tended to be reduced and this may also play a role in the reduction of MT-1A expression during differentiation. Taken together, these findings suggest that MT-1A is epigenetically regulated by PU.1 during monocytic differentiation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Suzuki S,Nakano H,Takahashi S

doi

10.1016/j.bbrc.2013.03.007

subject

Has Abstract

pub_date

2013-04-12 00:00:00

pages

349-53

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(13)00400-2

journal_volume

433

pub_type

杂志文章

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