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Contractile agonists preferentially activate CL- over K+ currents in arterial myocytes.

Abstract：

:Simultaneous patch-clamp and Ca2+ fluorescence measurements have revealed depolarising oscillations in the membrane potential of arterial (pulmonary) myocytes in response to adenosine 5'-triphosphate (ATP) and endothelin-1 (ET-1). These oscillations (i) are due to the preferential activation of Ca(2+)-activated Cl-, over K+ currents, (ii) occur through a mechanism involving Ca2+ release from intracellular Ca2+ stores and (iii) are likely to promote constriction. These results provide a novel perspective into the relative contribution and importance of Ca2+ activated Cl- and K+ channels in controlling membrane potential of arterial smooth muscle in response to contractile agonists.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Bakhramov A,Hartley SA,Salter KJ,Kozlowski RZ

doi

10.1006/bbrc.1996.1484

subject

Has Abstract

pub_date

1996-10-03 00:00:00

pages

168-75

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)91484-9

journal_volume

227

pub_type

杂志文章

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