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An enhancer in the c-mos locus binds a nuclear factor 1-like protein.

Abstract：

:We recently identified a DNA sequence element located in the rat c-mos protooncogene which fulfills operational criteria for enhancers, increasing transcription from a heterologous promoter in fibroblasts over large distances and in an orientation-independent manner. Here we report that three mouse nuclear proteins bind to the enhancer. Several lines of evidence indicate that one is a Nuclear Factor 1 like activity. Oligonucleotide-directed mutagenesis of the NF-1 binding site destroys binding of the protein, but leaves enhancer activity unaffected. Tumor growth factor-beta, which was shown to exert a stimulatory effect on the alpha 2(I) collagen promoter via its NF-1 binding site, has no effect on the activity of the enhancer. Thus, the NF-1 binding site of the c-mos enhancer is not essential for its activity in fibroblasts.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

van der Hoorn FA,Nordeen SK

doi

10.1016/0006-291x(89)91552-0

subject

Has Abstract

pub_date

1989-05-30 00:00:00

pages

8-15

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91552-0

journal_volume

161

pub_type

杂志文章

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