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Effective delivery of recombinant proteins to rod photoreceptors via lipid nanovesicles.

Abstract：

:The potential of liposomes to deliver functional proteins in retinal photoreceptors and modulate their physiological response was investigated by two experimental approaches. First, we treated isolated mouse retinas with liposomes encapsulating either recoverin, an important endogenous protein operating in visual phototransduction, or antibodies against recoverin. We then intravitrally injected in vivo liposomes encapsulating either rhodamin B or recoverin and we investigated the distribution in retina sections by confocal microscopy. The content of liposomes was found to be released in higher amount in the photoreceptor layer than in the other regions of the retina and the functional effects of the release were in line with the current model of phototransduction. Our study sets the basis for quantitative investigations aimed at assessing the potential of intraocular protein delivery via biocompatible nanovesicles, with promising implications for the treatment of retinal diseases affecting the photoreceptor layer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Asteriti S,Dal Cortivo G,Pontelli V,Cangiano L,Buffelli M,Dell'Orco D

doi

10.1016/j.bbrc.2015.04.088

subject

Has Abstract

pub_date

2015-06-12 00:00:00

pages

665-70

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)00792-5

journal_volume

461

pub_type

杂志文章

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