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USP39, a direct target of microRNA-133a, promotes progression of pancreatic cancer via the AKT pathway.

Abstract：

:Ubiquitin specific protease 39 (USP39) is one of the deubiquitinating enzymes without ubiquitin protease activity, which has been implicated in the progression of several cancers. However, the role of USP39 in pancreatic cancer (PC) is largely unknown. In present study, we found that USP39 expression was elevated in PC tissues than adjacent non-tumor tissues. Importantly, we demonstrated that overexpression of USP39 is closely correlated with tumor progression and poor survival in PC patients. Furthermore, high USP39 expression was observed in PC cell lines and ectopic expression of USP39 significantly enhanced in vitro cell proliferation and promoted in vivo tumor growth, whereas silencing USP39 suppressed growth of PC cells. Besides, our experimental data revealed that knockdown of USP39 induced cell apoptosis through inhibition of AKT signaling pathway in PC cells. Moreover, USP39 was a direct target of miR-133a, a microRNA that has been reported to be involved in progression of PC. Taken together, our data provide a novel PC regulatory axis that is miR-133a/USP39, the dysfunction of which drives diverse aspects of the progression of PC.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cai J,Liu T,Huang P,Yan W,Guo C,Xiong L,Liu A

doi

10.1016/j.bbrc.2017.03.025

subject

Has Abstract

pub_date

2017-04-22 00:00:00

pages

184-190

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)30482-5

journal_volume

486

pub_type

杂志文章

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