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Microtubule-associated proteins bind to 30 kDa and 60 kDa proteins of rat brain mitochondria: visualization by ligand blotting.

Abstract：

:Axonal transport of mitochondria is a microtubule-associated movement. Microtubule-mitochondria interactions were studied in vitro using organelles isolated from rat brain. Thanks to the ligand blotting method we were able to show two mitochondrial membrane proteins with apparent molecular masses of 30 kDa and 60 kDa that bind microtubule-associated proteins. The binding of the 30 kDa protein has an apparent Kd of 8 x 10(-8) M. Digitonin fractionation of mitochondria reveals a bimodal localization of the 30 kDa and the 60 kDa proteins within the outer membrane. The data suggest that these polypeptides could participate to the interactions observed in situ between microtubules and mitochondria.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Rendon A,Filliol D,Jancsik V

doi

10.1016/0006-291x(87)90435-9

subject

Has Abstract

pub_date

1987-12-16 00:00:00

pages

776-83

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90435-9

journal_volume

149

pub_type

杂志文章

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