Expression of c-myc oncogene during differentiation of human burst-forming unit, erythroid (BFU-E).

abstract：OBJECTIVE:Hepatic stellate cells (HSC) activation and proliferation mediated the pathogenic development of hepatic fibrosis (HF). However, the underlying mechanisms remain poorly understood. In this study, we aimed to investigate the miR-29a-3p and its effects on PIK3R3 expression in HF pathogenesis. METHODS:LX-2 cell...

journal_title：Biochemical and biophysical research communications

authors： Fu J,Wu B,Zhong S,Deng W,Lin F

更新日期：2020-09-03 00:00:00

abstract：:Din7 is a DNA damage-inducible mitochondrial nuclease that modulates the stability of mitochondrial DNA (mtDNA) in Saccharomyces cerevisiae. How DIN7 gene expression is regulated, however, has remained largely unclear. Using promoter sequence alignment, we found a highly conserved 19-bp sequence in the promoter region...

journal_title：Biochemical and biophysical research communications

authors： Yoshitani A,Yoshida M,Ling F

更新日期：2008-01-04 00:00:00

abstract：:miRNAs are recently found playing important roles in osteogenesis. In this study, we identified that miR-222-3p decreased during osteogenic differentiation of human mesenchymal stem cells (hBMSCs) using Quantitative Real-Time Reverse Transcription PCR (qRT-PCR). Furthermore, we investigated the effect of miR-222-3p on...

journal_title：Biochemical and biophysical research communications

authors： Yan J,Guo D,Yang S,Sun H,Wu B,Zhou D

更新日期：2016-02-12 00:00:00

abstract：:Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis. Two ACAT genes exist in mammals. We report here the genomic organization of human ACAT-2 gene and analysis of its promoter activity in various cell lines. The human ACAT-2 gene spans over 18 kb and contains 15 exons....

journal_title：Biochemical and biophysical research communications

authors： Song BL,Qi W,Yang XY,Chang CC,Zhu JQ,Chang TY,Li BL

更新日期：2001-03-30 00:00:00

abstract：:This study aimed at in vivo visualization of cyclooxygenase-2 (COX-2) by optical imaging using a representative compound of a class of autofluorescent 2,3-diaryl-substituted indole-based selective COX-2 inhibitors (2,3-diaryl-indole coxibs). COX-2 was successfully visualized in mice models with phorbol myristate ester...

journal_title：Biochemical and biophysical research communications

authors： Tondera C,Ullm S,Laube M,Meister S,Neuber C,Mosch B,Kniess T,Pietzsch J

更新日期：2015-02-27 00:00:00

abstract：:The rate limiting step in 5-fluorouracil catabolism is catalyzed by the enzyme dihydropyrimidine dehydrogenase. Since degradation of 5-fluorouracil decreases its efficacy in chemotherapy, the inhibition of its catabolism is a promising tool. We investigated the formation of micronuclei in vitro in mouse L5178Y cells. ...

journal_title：Biochemical and biophysical research communications

authors： Stopper H,Kühnel A,Podschun B

更新日期：1994-09-15 00:00:00

abstract：:Tissue-engineered grafts for tissue regeneration include either mature or progenitor cells seeded onto biomatrices that provide shape and support for developing tissue. Popular biomaterials used in orthopaedic surgery include collagen type I, hyaluronic acid, hydroxyapatite, and polylactic polyglycolic acid (PLGA). Bi...

journal_title：Biochemical and biophysical research communications

authors： Carlson GA,Dragoo JL,Samimi B,Bruckner DA,Bernard GW,Hedrick M,Benhaim P

更新日期：2004-08-20 00:00:00

abstract：:Herpes simplex virus-1 (HSV-1) glycoprotein E (gE) is a multifunctional protein capable of both binding the Fc portion of IgG and mediating cell-to-cell spread of HSV-1. Here we report that the domain on gE involved in IgG binding is distinct from the domain involved in mediating cell-to-cell spread. To do this we hav...

journal_title：Biochemical and biophysical research communications

authors： Weeks BS,Sundaresan P,Nagashunmugam T,Kang E,Friedman HM

更新日期：1997-06-09 00:00:00

abstract：:Based on a homology search with endostatin, the C-terminus 185 aa of collagen XVIII, we report the cloning, expression, and antiangiogenic activity of a 22 kDa human collagen XV fragment, that we have named restin. Restin was expressed in the prokaryotic pET expression system. We have shown that restin inhibits the mi...

journal_title：Biochemical and biophysical research communications

authors： Ramchandran R,Dhanabal M,Volk R,Waterman MJ,Segal M,Lu H,Knebelmann B,Sukhatme VP

更新日期：1999-02-24 00:00:00

abstract：:NF-kappaB family of transcription factors are involved in numerous cellular processes, including differentiation, proliferation, and inflammation. It was reported that hydroxycinnamic acid derivatives (HADs) are inhibitors of NF-kappaB activation. Rice bran oil contains a lot of phytosteryl ferulates, one of HADs. We ...

journal_title：Biochemical and biophysical research communications

authors： Nagasaka R,Chotimarkorn C,Shafiqul IM,Hori M,Ozaki H,Ushio H

更新日期：2007-06-29 00:00:00

abstract：:The present study was conducted to determine whether fetuin-A, a dominant serum protein plays a role in chemo-attraction and chemo-invasion of carcinoma cells in vitro. Serum is normally used as positive chemotaxis control in Boyden chamber motility assays, prompting the need to identify the factor/s in serum that con...

journal_title：Biochemical and biophysical research communications

authors： Nangami GN,Watson K,Parker-Johnson K,Okereke KO,Sakwe A,Thompson P,Frimpong N,Ochieng J

更新日期：2013-09-06 00:00:00

abstract：:ATP1B4 genes represent a rare instance of the orthologous gene co-option that radically changed functions of encoded BetaM proteins during vertebrate evolution. In lower vertebrates, this protein is a β-subunit of Na,K-ATPase located in the cell membrane. In placental mammals, BetaM completely lost its ancestral role ...

journal_title：Biochemical and biophysical research communications

authors： Pestov NB,Zhao H,Basrur V,Modyanov NN

更新日期：2011-09-09 00:00:00

abstract：:CHFR ubiquitin ligase acts as a checkpoint upon DNA damage and its functional inactivation is one of key characteristics of tumor development and metastasis. Despite the crucial role in maintaining genome integrity and cell cycle progression, little is known how CHFR stability is regulated. Here, we showed that CHFR i...

journal_title：Biochemical and biophysical research communications

authors： Kwon YE,Bae SJ,Kim M,Seol JH

更新日期：2013-01-04 00:00:00

abstract：:Mechanical loading of cultured mesangial cells has been shown to induce both increased production of matrix proteins and cell proliferation. This in vitro phenomenon has been implicated in the progression of glomerular sclerosis observed in a variety of glomerular diseases. However, it is not yet known how cells sense...

journal_title：Biochemical and biophysical research communications

authors： Hamasaki K,Mimura T,Furuya H,Morino N,Yamazaki T,Komuro I,Yazaki Y,Nojima Y

更新日期：1995-07-17 00:00:00

abstract：:HIV-infected subjects are at high risk of developing atherosclerosis, in part due to virus-induced impairment of HDL metabolism. Here, using as a model of HIV infection the NOD.Cg-Prkdc(scid)IL2rg(tm1Wjl)/SzJ (NSG) mice humanized by human stem cell transplantation, we demonstrate that LXR agonist TO901317 potently red...

journal_title：Biochemical and biophysical research communications

authors： Dubrovsky L,Van Duyne R,Senina S,Guendel I,Pushkarsky T,Sviridov D,Kashanchi F,Bukrinsky M

更新日期：2012-03-02 00:00:00

abstract：:We previously reported that moderate hypoxia and hypoxia-mimetic agents including cobalt chloride (CoCl(2)) induce differentiation of human acute myeloid leukemia (AML) cells through hypoxia-inducible factor-1 α (HIF-1 α), which interacts with and enhances transcriptional activity of CCAAT-enhancer binding factor alph...

journal_title：Biochemical and biophysical research communications

authors： Yan ZW,Hou JK,He W,Fan L,Huang Y

更新日期：2013-01-18 00:00:00

abstract：:Dynamic properties of spin-labelled heterosaccharides in the Fc-region of murine monoclonal antihapten immunoglobulin G were studied in model immune complexes (IC) as a function of the IC size. Model IC dimers, trimers and oligomers were formed using bivalent photoaffinity antigens. The ESR spectrum exhibits two compo...

journal_title：Biochemical and biophysical research communications

authors： Kusumi A,Winkelhake JL

更新日期：1986-05-29 00:00:00

abstract：:Monoamine oxidase B (MAO-B) functions in the deamination of monoamines, including dopamine and norepinephrine. The search for MAO-B inhibitors increased following the discovery that the enzyme may be responsible for generating neurotoxins from various endogenous or exogenous compounds. Computational screening methods ...

journal_title：Biochemical and biophysical research communications

authors： Harkcom WT,Bevan DR

更新日期：2007-08-24 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent and specific mitogen for vascular endothelial cells. A 3.9 kb VEGF transcript is expressed by all cardiac tissues from rat, mouse and guinea pig examined. VEGF expression was not developmentally regulated. The major form of VEGF mRNAs expressed by cardiac tissues c...

journal_title：Biochemical and biophysical research communications

authors： Ladoux A,Frelin C

更新日期：1993-09-15 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) expression is increased by hypertonicity. Therefore we hypothesized that hypertonicity increased PGE(2) can modulate the sodium transporters (Na(+)/K(+)-ATPase: NKA, epithelial sodium channel: ENaC, and sodium hydrogen exchanger: NHE) in M1 cortical collecting duct (CCD) cells. We demonstrated...

journal_title：Biochemical and biophysical research communications

authors： Nasrallah R,Paris G,Hébert RL

更新日期：2012-02-10 00:00:00

abstract：:To assess the relationship between cell proliferation and cell death, the mRNA accumulation of ornithine decarboxylase (ODC) and sulfated glycoprotein 2 (SGP-2) were measured in human peripheral blood lymphocytes (HPBL) 2-6 hours after stimulation with phytohemagglutinin (PHA). ODC is the rate limiting enzyme of polya...

journal_title：Biochemical and biophysical research communications

authors： Grassilli E,Bettuzzi S,Monti D,Ingletti MC,Franceschi C,Corti A

更新日期：1991-10-15 00:00:00

abstract：:Microtubules are made up of tubulin protein and play a very important part in numerous cellular events of eukaryotic cells, which is why they are seen as attractive targets for tumor chemotherapy. BNC105, a known vascular targeting agent, has entered in phase II clinical trials. It has previously been confirmed that B...

journal_title：Biochemical and biophysical research communications

authors： Wang T,Wu C,Wang C,Zhang G,Arnst KE,Yao Y,Zhang Z,Wang Y,Pu D,Li W

更新日期：2020-02-18 00:00:00

abstract：:Lung cancer is a major cause of cancer-related mortality in the United States and around the world. Due to the pre-existing or acquired chemo-resistance, the current standard chemotherapy regimens only show moderate activity against lung cancer. In the current study, we explored the potential anti-lung cancer activity...

journal_title：Biochemical and biophysical research communications

authors： Kai S,Lu JH,Hui PP,Zhao H

更新日期：2014-09-26 00:00:00

abstract：:The physical behavior of total lipids, microsomes and microsomal lipids prepared from brain hemispheres of European Hamsters (Cricetus cricetus) was approached by the measure of the fluorescence polarization of the probe 1,6-diphenyl 1,3,5-hexatriene. We compare in this study the results obtained for two critical peri...

journal_title：Biochemical and biophysical research communications

authors： Montaudon D,Robert J,Canguilhem B

更新日期：1984-02-29 00:00:00

abstract：:We demonstrate that the 204 bp intronic gene fragment of C3(1), which has a specific in vitro affinity for the androgen receptor, is able to confer androgen responsiveness to a heterologous promoter. This characteristic is completely destroyed by a single G----T substitution, affecting a 5'-TGTTCT-3' element that clos...

journal_title：Biochemical and biophysical research communications

authors： Claessens F,Celis L,Peeters B,Heyns W,Verhoeven G,Rombauts W

更新日期：1989-10-31 00:00:00

abstract：:The circular RNA (circRNA) circEPSTI1 has been recently identified as a new cancer-associated circRNA in multiple types of cancer. However, the involvement of circEPSTI1 in non-small cell lung cancer (NSCLC) remains unexplored. The purpose of this study was to explore the expression pattern and function of circEPSTI1 ...

journal_title：Biochemical and biophysical research communications

authors： Yang T,Li M,Li H,Shi P,Liu J,Chen M

更新日期：2020-09-10 00:00:00

abstract：:A novel aptameric enzyme subunit (AES) which can detect target DNAs has been developed. AES is an enzyme-inhibiting aptamer bearing a target-molecule binding site which can allosterically control enzymatic activity. The thrombin-inhibiting aptamer bearing a G-quartet structure was chosen as the enzyme-inhibiting aptam...

journal_title：Biochemical and biophysical research communications

authors： Yoshida W,Sode K,Ikebukuro K

更新日期：2006-09-15 00:00:00

abstract：:Adrenal medullary chromaffin cells maintained in vitro were prelabeled with [3H]inositol and the accumulation of [3H]inositol-1-phosphate, was determined following stimulation with a variety of pharmacological agents. Carbachol, bradykinin, and histamine produced significantly greater accumulation of [3H] inositol-1-p...

journal_title：Biochemical and biophysical research communications

authors： Noble EP,Bommer M,Sincini E,Costa T,Herz A

更新日期：1986-03-13 00:00:00

abstract：:Rett syndrome is an X-linked neurodevelopmental disorder that develops a profound intellectual and motor disability and affects 1 from 10 000 to 15 000 live female births. This disease is characterized by a period of apparently normal development until 6-18 months of age when motor and communication abilities regress ...

journal_title：Biochemical and biophysical research communications

authors： Ghorbel R,Ghorbel R,Rouissi A,Fendri-Kriaa N,Ben Salah G,Belguith N,Ammar-Keskes L,Gouider-Khouja N,Fakhfakh F

更新日期：2018-02-26 00:00:00

abstract：:The fragile X syndrome, one of the most common forms of inherited mental retardation, is caused by an expansion of a polymorphic CGG repeat upstream the coding region of the FMR1 gene. These expansions are associated with hypermethylation of the FMR1 gene, which results in the absence of the gene product, the FMR1 pro...

journal_title：Biochemical and biophysical research communications

authors： Willemsen R,Bontekoe C,Tamanini F,Galjaard H,Hoogeveen A,Oostra B

更新日期：1996-08-05 00:00:00