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Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection.

Abstract：

:HIV-infected subjects are at high risk of developing atherosclerosis, in part due to virus-induced impairment of HDL metabolism. Here, using as a model of HIV infection the NOD.Cg-Prkdc(scid)IL2rg(tm1Wjl)/SzJ (NSG) mice humanized by human stem cell transplantation, we demonstrate that LXR agonist TO901317 potently reduces viral replication and prevents HIV-induced reduction of plasma HDL. These results establish that humanized mice can be used to investigate the mechanisms of HIV-induced impairment of HDL formation, a major feature of dyslipidemia associated with HIV-1 infection, and show potential benefits of developing LXR agonists for treatment of HIV-associated cardio-vascular disease.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Dubrovsky L,Van Duyne R,Senina S,Guendel I,Pushkarsky T,Sviridov D,Kashanchi F,Bukrinsky M

doi

10.1016/j.bbrc.2012.01.137

subject

Has Abstract

pub_date

2012-03-02 00:00:00

pages

95-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)00191-X

journal_volume

419

pub_type

杂志文章

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