Differential signaling signatures evoked by DOI versus lisuride stimulation of the 5-HT2A receptor.

abstract：:The most recently described region of alternate splicing of fibronectin mRNA results in expression of an isoform which includes the type III repeat termed ED B (EIII B). To date this isoform has been detected in transformed cells in culture, in the synovial membrane and ovary but in no other adult tissue, and in embry...

journal_title：Biochemical and biophysical research communications

authors： Burton-Wurster N,Lust G,Wert R

更新日期：1989-12-15 00:00:00

abstract：:The breakdown of blood clots requires the fibrinolytic action of the serine proteinase plasmin, a two-chain polypeptide derived posttranslationally from its precursor zymogen, plasminogen. While investigating plasminogen gene expression in human extrahepatic tissues, a cDNA sequence was obtained which closely resemble...

journal_title：Biochemical and biophysical research communications

authors： Weissbach L,Treadwell BV

更新日期：1992-07-31 00:00:00

abstract：:Diabetes is a chronic disease that disrupts the balance between bone formation and bone desorption, which can lead to osteoporosis, increasing the risk of fracture. However, compared with osteoblasts, the biological effects of hyperglycemia on osteoclastogenesis remain to be elucidated. Therefore, we investigated the ...

journal_title：Biochemical and biophysical research communications

authors： Cai ZY,Yang B,Shi YX,Zhang WL,Liu F,Zhao W,Yang MW

更新日期：2018-09-05 00:00:00

abstract：:An early signaling event during the adhesion and spreading of cells is integrin-mediated tyrosine phosphorylation of the cytoskeletal adaptor protein paxillin and the non-receptor tyrosine kinase pp125(FAK) at focal contacts. To determine the influence of surface-charge and -adsorbed adhesion proteins on this signalin...

journal_title：Biochemical and biophysical research communications

authors： Sommerfeldt DW,McLeod KJ,Rubin CT,Hadjiargyrou M

更新日期：2001-07-13 00:00:00

abstract：:Fluid flowing through the bone porosity might be a primary stimulus for functional adaptation of bone. Osteoblasts, and osteocytes in particular, respond to fluid flow in vitro with enhanced nitric oxide (NO) and prostaglandin E(2) (PGE(2)) release; both of these signaling molecules mediate mechanically-induced bone f...

journal_title：Biochemical and biophysical research communications

authors： McGarry JG,Klein-Nulend J,Prendergast PJ

更新日期：2005-04-29 00:00:00

abstract：:Carboxysome, encapsulating an enzymatic core within an icosahedral-shaped semipermeable protein shell, could enhance CO2 fixation under low CO2 conditions in the environment. The shell of Halothiobacillus neapolitanus α-carboxysome possesses two 38% sequence-identical pentameric proteins, namely CsoS4A and CsoS4B. How...

journal_title：Biochemical and biophysical research communications

authors： Zhao YY,Jiang YL,Chen Y,Zhou CZ,Li Q

更新日期：2019-07-30 00:00:00

abstract：:The exposure of organ cultured pineal glands of Syrian hamsters to forskolin, an adenylate cyclase activator, caused marked increases in serotonin N-acetyltransferase activity and melatonin content in a dose-related manner (1-100 microM) when glands were collected in the second half of the dark period. However, additi...

journal_title：Biochemical and biophysical research communications

authors： Santana C,Guerrero JM,Reiter RJ,Gonzalez-Brito A,Menendez-Pelaez A

更新日期：1988-08-30 00:00:00

abstract：:Although the first members of the Schlafen gene family were first described almost 10 years ago, the precise molecular/biochemical functions of the proteins they encode still remain largely unknown. Roles in cell growth, haematopoietic cell differentiation, and T cell development/maturation have, with some experimenta...

journal_title：Biochemical and biophysical research communications

authors： Neumann B,Zhao L,Murphy K,Gonda TJ

更新日期：2008-05-23 00:00:00

abstract：:Native LDL would be a mitogenic and chemotactic stimulus of VSMC proliferation and differentiation in the atherosclerotic lesion where endothelial disruption occurred. In previous studies, our group investigated the molecular mechanisms by which LDL induces IL-8 production and by which PPARalpha activation abolishes L...

journal_title：Biochemical and biophysical research communications

authors： Heo KS,Kim DU,Ryoo S,Nam M,Baek ST,Kim L,Park SK,Myung CS,Hoe KL

更新日期：2007-08-10 00:00:00

abstract：:Jmjd2c is a candidate oncogene that encodes histone lysine demethylase. In this study, we discovered that over-expression of Jmjd2c increased the expression of Mdm2 oncogene dependent on its demethylase activity, which led to the reduction of p53 tumor suppressor gene product in the cells. A chromatin immunoprecipitat...

journal_title：Biochemical and biophysical research communications

authors： Ishimura A,Terashima M,Kimura H,Akagi K,Suzuki Y,Sugano S,Suzuki T

更新日期：2009-11-13 00:00:00

abstract：:miR-130b was significantly up-regulated in osteosarcoma (OS) cells. Naked cuticle homolog 2 (NKD2) inhibited tumor growth and metastasis in OS by suppressing Wnt signaling. We used three miRNA target analysis tools to identify potential targets of miR-130b, and found that NKD2 is a potential target of miR-130b. Based ...

journal_title：Biochemical and biophysical research communications

authors： Li Z,Li Y,Wang N,Yang L,Zhao W,Zeng X

更新日期：2016-03-18 00:00:00

abstract：:We investigated the effect of ziprasidone, a widely used treatment for schizophrenia, on voltage-dependent K+ (Kv) channels of coronary arterial smooth muscle cells using the patch-clamp technique. Ziprasidone dose-dependently inhibited Kv channels with an IC50 value of 0.39 ± 0.06 μM and a Hill coefficient of 0.62 ± ...

journal_title：Biochemical and biophysical research communications

authors： An JR,Seo MS,Jung HS,Heo R,Kang M,Ha KS,Park H,Park WS

更新日期：2020-08-20 00:00:00

abstract：:Human endothelial cell thrombin receptors were functionally expressed in Xenopus laevis oocytes by injection of RNA extracted from human umbilical vein endothelial cells. Oocytes injected with endothelial cell RNA responded to thrombin with a Ca2(+)-dependent depolarizing current whose size depended on the amount of R...

journal_title：Biochemical and biophysical research communications

authors： Pipili-Synetos E,Gershengorn MC,Jaffe EA

更新日期：1990-09-28 00:00:00

abstract：:We have identified two neuropeptides (F1 and F2) from suboesophageal and thoracic ganglia of Locusta migratoria, which we isolated earlier based on their immunological similarity to arginine vasopressin. The more abundant and hydrophilic factor, F1, has sequence Cys-Leu-Ile-Thr-Asn-Cys-Pro-Arg-Gly-NH2, but its biologi...

journal_title：Biochemical and biophysical research communications

authors： Proux JP,Miller CA,Li JP,Carney RL,Girardie A,Delaage M,Schooley DA

更新日期：1987-11-30 00:00:00

abstract：:Previous studies showed that insulin stimulation of electrogenic Na+ transport in renal epithelial cells is mediated by a calcium-dependent signal transduction mechanism. The present study was performed to determine whether the insulin-induced increase in intracellular Ca2+ (Cai2+) was mediated by hydrolysis of phosph...

journal_title：Biochemical and biophysical research communications

authors： Isales C,Macala LJ,Rodriguez-Commes J,Gasalla-Herraiz J,Hayslett JP

更新日期：1997-02-03 00:00:00

abstract：:The basic helix-loop-helix (bHLH) transcription factor mammalian achaete-scute homolog-1 (MASH-1 in mouse and HASH-1 in human) is essential for proper development of olfactory and most peripheral autonomic neurons, and for the formation of distinct neuronal circuits within the central nervous system. We have previousl...

journal_title：Biochemical and biophysical research communications

authors： Persson P,Jögi A,Grynfeld A,Påhlman S,Axelson H

更新日期：2000-07-21 00:00:00

abstract：:Transfer of the gene for L-gulono-gamma-lactone oxidase, the missing enzyme in L-ascorbic acid biosynthesis in scurvy-prone animals, into medaka (Oryzias latipes) was successfully done. The expression plasmid pSVL-GLO, carrying rat liver L-gulono-gamma-lactone oxidase cDNA, was microinjected into the cytoplasm of fert...

journal_title：Biochemical and biophysical research communications

authors： Toyohara H,Nakata T,Touhata K,Hashimoto H,Kinoshita M,Sakaguchi M,Nishikimi M,Yagi K,Wakamatsu Y,Ozato K

更新日期：1996-06-25 00:00:00

abstract：:Chronic exposure of L6 myocytes to insulin/IGF-1 or glucose deprivation results in an increase in the level of brain-type glucose transporter (GLUT1) mRNA. We have investigated the effects of insulin and glucose deprivation on GLUT1 mRNA stability. The half-life of GLUT1 mRNA in control cells was 2-2.5 h. Insulin incr...

journal_title：Biochemical and biophysical research communications

authors： Maher F,Harrison LC

更新日期：1990-08-31 00:00:00

abstract：:Recent evidence suggests that during aging there is widespread accumulation of aggregated insoluble proteins, even in the absence of pathological conditions. Pharmacological manipulation of protein aggregation might be helpful to unveil the involvement of protein aggregates during aging, as well as to develop novel st...

journal_title：Biochemical and biophysical research communications

authors： Cuanalo-Contreras K,Park KW,Mukherjee A,Millán-Pérez Peña L,Soto C

更新日期：2017-01-01 00:00:00

abstract：:Focal adhesion kinase (FAK) and integrin-linked kinase (ILK) are both involved in integrin-mediated cell migration. However, the molecular mechanism, and the relationship between FAK and ILK activity in signaling transduction for the osteopontin (OPN)-induced migration of vascular smooth muscle cells (VSMCs) remain un...

journal_title：Biochemical and biophysical research communications

authors： Li JJ,Han M,Wen JK,Li AY

更新日期：2007-04-27 00:00:00

abstract：:The mechanism(s) by which HIV-1 infection contributes to depletion of CD4(+) T cell is not well understood. In this report, we investigated whether a recently identified isoform of growth factor receptor bound protein (Grb2), named Grb3-3, a signaling molecule that is associated with the MAP kinase pathway and with ap...

journal_title：Biochemical and biophysical research communications

authors： Li X,Multon MC,Henin Y,Schweighoffer F,Venot C,LaVecchio J,Josef J,Stuckert P,Mhashilkar A,Tocqué B,Marasco WA

更新日期：2000-09-16 00:00:00

abstract：:Nicastrin is a recently discovered protein interacting with presenilins and the beta-amyloid precursor protein, the proteins playing key roles in Alzheimer's disease and which, when mutated, appear responsible for early-onset familial forms of Alzheimer's disease. Nicastrin was reported to modulate beta-amyloid produc...

journal_title：Biochemical and biophysical research communications

authors： Fergani A,Yu G,St George-Hyslop P,Checler F

更新日期：2001-12-07 00:00:00

abstract：:While there have been many single-molecule studies of kinesin-1, most have been done along microtubules purified from bovine or porcine brain, and relatively little is known about how variations in tubulin might alter motor function. Of particular interest is transport along microtubules polymerized from tubulin purif...

journal_title：Biochemical and biophysical research communications

authors： Feizabadi MS,Jun Y

更新日期：2014-11-28 00:00:00

abstract：:The aim of this study was to investigate the possible pathological relation between mechanical stress and hyperpigmentation. We did this by investigating the influence of cyclic stretch on the expression of keratinocyte- and fibroblast-derived melanogenetic paracrine cytokines in vitro. Using primary human keratinocyt...

journal_title：Biochemical and biophysical research communications

authors： Kurita M,Okazaki M,Fujino T,Takushima A,Harii K

更新日期：2011-05-27 00:00:00

abstract：:In addition to its interaction at hypothalamic sites to affect feeding and energy expenditure, leptin has been shown to exhibit a proliferative response in erythropoietic cells. The functional leptin receptor is also present in pancreatic islets and we now demonstrate that a commonly used clonal insulin secreting beta...

journal_title：Biochemical and biophysical research communications

authors： Islam MS,Morton NM,Hansson A,Emilsson V

更新日期：1997-09-29 00:00:00

abstract：:In cardiac myocytes, cromakalim (BRL 34915), a potassium channel opener, activates a time-independent K+ current exhibiting poor voltage-sensitivity. This effect of cromakalim is antagonized by low concentrations of glibenclamide, a specific blocker of ATP-dependent K+ channels in cardiac cells. Direct recording of th...

journal_title：Biochemical and biophysical research communications

authors： Escande D,Thuringer D,Leguern S,Cavero I

更新日期：1988-07-29 00:00:00

abstract：:The tissue targeting and rate of clearance of cobra venom factor (CVF) from the circulation was studied in mice by intravenous or intraperitoneal injection of radioiodinated CVF. In both modes of administrations, CVF was targeted mainly to liver. CVF injected directly into the blood was cleared from the circulation wi...

journal_title：Biochemical and biophysical research communications

authors： Fu Q,Satyaswaroop PG,Gowda DC

更新日期：1997-02-13 00:00:00

abstract：:Apolipoprotein (apo-) B mRNA editing at nucleotide 6666 converts cytidine to uridine, transforming the codon for glutamine-2153 to a termination codon. To investigate this editing mechanism, [a-32P] and [5-3H] CTP were incorporated into synthetic apo-B RNA. After the substrate had been edited extensively in vitro by a...

journal_title：Biochemical and biophysical research communications

authors： Johnson DF,Poksay KS,Innerarity TL

更新日期：1993-09-30 00:00:00

abstract：:Cholinesterases in the oat cell were found to be distributed in the cell wall (50%) and cytoplasm (42%). Activity of the cytosolic enzyme was inhibited about 80% by 1 mM Ca2+. The enzyme activity was also inhibited by Mn2+, but no inhibition by Mg2+ was observed. Effects of red light and calcium ion on the enzyme acti...

journal_title：Biochemical and biophysical research communications

authors： Kim HY,Kim TI,Kim HK,Chae Q

更新日期：1990-05-31 00:00:00

abstract：:When rat hepatoma cells (R-Y121B) were incubated with insulin at 37 degrees C, concanavalin A increased insulin internalization into cells. When R-Y121B cells were first incubated with labeled insulin at 4 degrees C then with concanavalin A at various concentrations at 37 degrees C, the total cellular radioactivity wa...

journal_title：Biochemical and biophysical research communications

authors： Sorimachi K,Yasumura Y

更新日期：1984-07-18 00:00:00