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Anti-inflammatory effects of hydroxycinnamic acid derivatives.

Abstract：

:NF-kappaB family of transcription factors are involved in numerous cellular processes, including differentiation, proliferation, and inflammation. It was reported that hydroxycinnamic acid derivatives (HADs) are inhibitors of NF-kappaB activation. Rice bran oil contains a lot of phytosteryl ferulates, one of HADs. We have investigated effects of phytosteryl ferulates on NF-kappaB activation in macrophage. Cycloartenyl ferulate (CAF), one of phytosteryl ferulates, significantly reduced lipopolysaccharide (LPS)-induced NO production and mRNA expression of inducible NO synthase and cyclooxygenese-2 but upregulated SOD activity. Electrophoresis mobility shift assay revealed that CAF inhibited DNA-binding of NF-kappaB. CAF and phytosteryl ferulates probably have potentially anti-inflammatory properties.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nagasaka R,Chotimarkorn C,Shafiqul IM,Hori M,Ozaki H,Ushio H

doi

10.1016/j.bbrc.2007.04.178

subject

Has Abstract

pub_date

2007-06-29 00:00:00

pages

615-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)00918-7

journal_volume

358

pub_type

杂志文章

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