Bacteriostatic properties of biomatrices against common orthopaedic pathogens.

Abstract:

:Tissue-engineered grafts for tissue regeneration include either mature or progenitor cells seeded onto biomatrices that provide shape and support for developing tissue. Popular biomaterials used in orthopaedic surgery include collagen type I, hyaluronic acid, hydroxyapatite, and polylactic polyglycolic acid (PLGA). Biomatrices with bacteriostatic properties may be beneficial in promoting tissue-engineered graft survival in patients susceptible to infection. We evaluated the bacteriostatic effects of these biomaterials on the growth of the four most common orthopaedic bacterial pathogens: Staphylococcus aureus, Staphylococcus epidermidis, beta-hemolytic Streptococcus, and Pseudomonas aeruginosa. Hyaluronic acid demonstrated the largest bacteriostatic effect on these pathogens by inhibiting bacterial growth by an average of 76.8% (p = 0.0005). Hydroxyapatite and collagen inhibited growth on average by 49.7% (p = 0.011) and 37.5% (p = 0.102), respectively. PLGA exhibited the least bacteriostasis with an average inhibition of 9.8% (NS) and actually accelerated the growth of beta-hemolytic Streptococcus and P. aeruginosa.

authors

Carlson GA,Dragoo JL,Samimi B,Bruckner DA,Bernard GW,Hedrick M,Benhaim P

doi

10.1016/j.bbrc.2004.06.165

subject

Has Abstract

pub_date

2004-08-20 00:00:00

pages

472-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)01417-2

journal_volume

321

pub_type

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