Cooperative binding of gamma-glutamyl substrate to human glutathione synthetase.

abstract：:Zinc ion in solution yields a 560-fold enhancement in the kinetic inhibition of carboxypeptidase A by the simple heterocycle imidazole, behavior attributed to formation of a ternary complex of the three species. However, the effect is partially negated by formation of less-inhibitory Zn2+(C3H4N2)2-4 coordination compl...

journal_title：Biochemical and biophysical research communications

authors： Mock WL,Wang L

更新日期：1999-04-02 00:00:00

abstract：:Lampreys are one of the most primitive vertebrates diverged some 500 million years ago. It has long been known that parasitic lampreys secrete anticoagulant from their buccal glands and prevent blood coagulation of host fishes. We found two major protein components of 160 and 26 kDa in the buccal gland secretion of pa...

journal_title：Biochemical and biophysical research communications

authors： Ito N,Mita M,Takahashi Y,Matsushima A,Watanabe YG,Hirano S,Odani S

更新日期：2007-06-22 00:00:00

abstract：:Mutations in the WNK1 and WNK4 genes result in an inherited hypertensive disease, pseudohypoaldosteronism type II (PHAII). Recently, the KLHL3 and Cullin3 genes were also identified as responsible genes for PHAII. Although we have reported that WNK4 is a substrate for the KLHL3-Cullin3 E3 ligase complex, it is not cle...

journal_title：Biochemical and biophysical research communications

authors： Takahashi D,Mori T,Wakabayashi M,Mori Y,Susa K,Zeniya M,Sohara E,Rai T,Sasaki S,Uchida S

更新日期：2013-08-02 00:00:00

abstract：:Upon glucose depletion, a massive reprogramming of gene expression occurs in the yeast Saccharomyces cerevisiae for the use of alternate carbon sources such as the nonfermentable compounds ethanol and glycerol. This process is mediated by the master kinase Snf1 that controls the activity of various targets including t...

journal_title：Biochemical and biophysical research communications

authors： Soontorngun N,Baramee S,Tangsombatvichit C,Thepnok P,Cheevadhanarak S,Robert F,Turcotte B

更新日期：2012-07-13 00:00:00

abstract：:Under standard conditions, in the presence of GTP, highly purified eIF-2 and Co-eIF-2 factor preparations efficiently stimulated AUG-codon dependent but not physiological mRNA-dependent Met-tRNAf binding to 40S ribosomes. Replacement of GTP by a nonhydrolyzable GTP analog, GMP-PNP, in the above system, gave significan...

journal_title：Biochemical and biophysical research communications

authors： Roy R,Nasrin N,Ahmad MF,Gupta NK

更新日期：1984-08-16 00:00:00

abstract：:Some properties of calmodulin(CaM)-binding proteins (CaMBPs) of the Ca(2+)-independent type were investigated in the synaptosomal membrane (SM) from rat brain using the [125I]CaM gel overlay method. When SM was prepared in the presence of Ca2+, Ca(2+)-independent CaM binding was decreased, whereas the Ca(2+)-dependent...

journal_title：Biochemical and biophysical research communications

authors： Natsukari N,Miwa A,Fujita M

更新日期：1992-03-16 00:00:00

abstract：:CYP1A1 is largely involved in carcinogenesis through the bioactivation of numerous procarcinogens. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway. We have previously demonstrated that fetal bovine serum (FBS) induces CYP1A1 gene transcr...

journal_title：Biochemical and biophysical research communications

authors： N'Guyen QB,Fallone F,Seree E,Fina F,Villard PH,Guigal N,De Meo M,Lacarelle B,Martin PM,Barra Y

更新日期：2002-09-20 00:00:00

abstract：:Maturity-onset diabetes of the young (MODY) is an autosomal dominant form of diabetes characterized by early onset of pancreatic dysfunction. MODY type 3 is caused by mutations in the hepatocyte nuclear factor (HNF)-1alpha. During a screening of Norwegian patients with suspected MODY we identified two novel HNF-1alpha...

journal_title：Biochemical and biophysical research communications

authors： Bjørkhaug L,Ye H,Horikawa Y,Søvik O,Molven A,Njølstad PR

更新日期：2000-12-29 00:00:00

abstract：:Quite extraordinarily molybdenum is an essential element in life for the uptake of nitrogen from both nitrogen gas and nitrate, yet it is a relatively rare heavy trace element. It also functions in a few extremely important oxygen-atom transfer reactions at low redox potential. This review poses the question "Why does...

journal_title：Biochemical and biophysical research communications

authors： Williams RJ,Fraústo da Silva JJ

更新日期：2002-03-29 00:00:00

abstract：:Voltage-gated potassium (K+) channel sub-family B member 1 (KCNB1, Kv2.1) is known to undergo oxidation-induced oligomerization during aging but whether this process affects brain's physiology was not known. Here, we used 10, 16 and 22 month-old transgenic mice overexpressing a KCNB1 variant that does not oligomerize ...

journal_title：Biochemical and biophysical research communications

authors： Yu W,Zhang H,Shin MR,Sesti F

更新日期：2019-05-14 00:00:00

abstract：:The exons of the lecithin:cholesterol acyltransferase (LCAT) gene in DNA samples from two of the original Swedish Fish Eye Disease patients have been amplified by polymerase chain reactions and sequenced by the dideoxy method. The two patients apparently were unrelated. In both patients a mutation in codon 10 of the f...

journal_title：Biochemical and biophysical research communications

authors： Skretting G,Prydz H

更新日期：1992-01-31 00:00:00

abstract：:Rab proteins, members of the Ras superfamily of small GTPases, play regulatory roles in intercompartmental vesicular transport. Each step of traffic seems to require the participation of at least one distinct Rab, with the Rab3 subfamily involved in stimulated exocytosis. We report our studies on the murine rab3D gene...

journal_title：Biochemical and biophysical research communications

authors： Adachi R,Nigam R,Tuvim MJ,DeMayo F,Dickey BF

更新日期：2000-07-14 00:00:00

abstract：:Wnt-1, the vertebrate counterpart of the Drosophila wingless gene, plays an important role in the early morphogenesis of neural tissues. In this report, we have shown that overexpression of Wnt-1 can direct embryonic carcinoma P19 cells to differentiate into neuron-like cells in the absence of retinoic acid. Immunocyt...

journal_title：Biochemical and biophysical research communications

authors： Tang K,Yang J,Gao X,Wang C,Liu L,Kitani H,Atsumi T,Jing N

更新日期：2002-04-26 00:00:00

abstract：:In fresh water planarian Dugesia japonica, two genes encoding POU-domain proteins, DjPOU1 and DjPOU2, have been identified by polymerase chain reaction (PCR). Their POU-domains are strikingly similar to class III POU-domains in mammals, frog, insects and nematode. The full-length cDNA of DjPOU1 has been cloned and seq...

journal_title：Biochemical and biophysical research communications

authors： Orii H,Agata K,Watanabe K

更新日期：1993-05-14 00:00:00

abstract：INTRODUCTION:Multiple myeloma (MM) remains incurable due to high rates of relapse after various treatment regimens. WEE1 is a cell cycle related gene that regulates the G2/M checkpoint and promotes cell cycle suspension for consequent DNA repair. To date, there are clinical studies for the evaluation of WEE1 inhibitors...

journal_title：Biochemical and biophysical research communications

authors： Barbosa RSS,Dantonio PM,Guimarães T,de Oliveira MB,Fook Alves VL,Sandes AF,Fernando RC,Colleoni GWB

更新日期：2019-11-12 00:00:00

abstract：:Membrane-type 1 matrix metalloproteinase (MT1-MMP) localized on the plasma membrane plays a central role in various normal biological responses including tissue remodeling, wound heeling, and angiogenesis and in cancer cell invasion and metastasis, by functioning as a collagenase and activating other matrix metallopro...

journal_title：Biochemical and biophysical research communications

authors： Miyata T,Ohnishi H,Suzuki J,Yoshikumi Y,Ohno H,Mashima H,Yasuda H,Ishijima T,Osawa H,Satoh K,Sunada K,Kita H,Yamamoto H,Sugano K

更新日期：2004-10-08 00:00:00

abstract：:1-Methyl-4-phenylpyridinium (MPP+)-treated human neuroblastoma SH-SY5Y cells have been generally accepted as a cellular model for Parkinson's disease. To understand comprehensive metabolic disturbances in this model, both cell lysates and culture supernatants were subjected to metabolomic analysis. As expected from th...

journal_title：Biochemical and biophysical research communications

authors： Amo T,Oji Y,Saiki S,Hattori N

更新日期：2019-11-12 00:00:00

abstract：:A sample of highly oriented Na-hyaluronate was prepared with a wet--spinning method and equilibrated to 75% relative humidity. Its proton NMR spectrum was recorded as a function of the angle theta between the hyaluronate helix axis and the external magnetic field. It appeared as a singlet with an angle-dependent line ...

journal_title：Biochemical and biophysical research communications

authors： Lahajnar G,Rupprecht A

更新日期：1986-11-26 00:00:00

abstract：:A series of synthetic peptide substrates for vertebrate collagenase having the structure Ac-Pro-Leu-Gly-X-Leu-Gly-OC2H5, where X is Leu, Ile, Val, Phe and Ala, have been prepared. Collagenolytic enzymes from various sources cleave these substrates with differing relative rate patterns. This series of peptides should b...

journal_title：Biochemical and biophysical research communications

authors： Weingarten H,Feder J

更新日期：1986-09-30 00:00:00

abstract：:Tight junctions (TJs) restrict paracellular flux of water and solutes in epithelia and endothelia. In epidermis, the physiological role of TJs is not fully understood. In this study, sodium caprate (C10), which dilates intestinal TJs, was applied to cultured human epidermal keratinocytes and reconstructed human epider...

journal_title：Biochemical and biophysical research communications

authors： Kurasawa M,Kuroda S,Kida N,Murata M,Oba A,Yamamoto T,Sasaki H

更新日期：2009-04-03 00:00:00

abstract：:It has been suggested that curcumin and other sarcoplasmic/endoplasmic reticulum Ca(2+)-pump inhibitors could correct the defect in the most common mutation (DeltaF508) in cystic fibrosis (CF), and restore normal chloride transport. In the present study, the effect of curcumin was tested on baby hamster kidney (BHK) c...

journal_title：Biochemical and biophysical research communications

authors： Dragomir A,Björstad J,Hjelte L,Roomans GM

更新日期：2004-09-17 00:00:00

abstract：:Ischemic stroke is a major cause of death and disability worldwide. Hyperneuroinflammation significantly contributes to ischemic stroke. Bromodomain-containing protein 4 (BRD4) is a member of the Bromo and Extra-Terminal (BET) family, and promotes inflammatory response in various types of tissue and cells. Thereby, we...

journal_title：Biochemical and biophysical research communications

authors： Zhou Y,Gu Y,Liu J

更新日期：2019-11-12 00:00:00

abstract：:The Notch3 N-terminal sequence is conserved across several mammalian species but diverges from the three other Notch proteins. We determined the significance of the N-terminal sequence using deletion mutants. The first 39 amino acids are required for Notch3 receptor expression, processing, and functional activity. In ...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Jia L,Lee SJ,Wang MM

更新日期：2007-03-30 00:00:00

abstract：:Calcineurin Inhibitors (CNIs) are routinely used for immunosuppression following solid organ transplantation. However, the prolonged use of these agents lead to organ fibrosis which limits their efficacy. CNIs induce TGFβ expression, which is reported to augment endothelial-to-mesenchymal transition (EndMT), but their...

journal_title：Biochemical and biophysical research communications

authors： Woda CB,Bruneau S,Mak AL,Haskova Z,Liu K,Ghosh CC,Briscoe DM

更新日期：2019-11-19 00:00:00

abstract：:Rosiglitazone is a ligand of peroxisome proliferation-activated receptor gamma (PPARγ). However, it exerts biological activities and therapeutic effects through both PPARγ-dependent and independent mechanisms. In this study, we defined that rosiglitazone was also a ligand of retinoid X receptor alpha (RXRα) and displa...

journal_title：Biochemical and biophysical research communications

authors： Huang F,Li Y,Chen J,Zhang XK,Zhou H

更新日期：2020-09-10 00:00:00

abstract：:Although neuraminidase (NA) is the second major viral glycoprotein of influenza virus, its immune mechanism as a vaccine target has been less considered. Here we compared the properties of antibodies and the efficacy of cross protection by N1 and N2 NA proteins, inactivated split influenza vaccines (split), and tandem...

journal_title：Biochemical and biophysical research communications

authors： Kim YJ,Ko EJ,Kim MC,Lee YN,Kim KH,Jung YJ,Kang SM

更新日期：2017-11-04 00:00:00

abstract：:Inflammation has been implicated in a variety of psychiatric disorders. We aimed to determine whether levels of complement C5 protein in the cerebrospinal fluid (CSF), which may reflect activation of the complement system in the brain, are altered in patients with major psychiatric disorders. Additionally, we examined...

journal_title：Biochemical and biophysical research communications

authors： Ishii T,Hattori K,Miyakawa T,Watanabe K,Hidese S,Sasayama D,Ota M,Teraishi T,Hori H,Yoshida S,Nunomura A,Nakagome K,Kunugi H

更新日期：2018-03-04 00:00:00

abstract：:We identified a species relevant to polo-like kinase family, a human homologue of mouse serum-inducible kinase, hSNK gene, whose mRNA expression was rapidly increased in cultured human thyroid cells after X-ray irradiation. The cDNA cloning and genomic analysis of the hSNK gene showed the presence of 14 exons spanning...

journal_title：Biochemical and biophysical research communications

authors： Shimizu-Yoshida Y,Sugiyama K,Rogounovitch T,Ohtsuru A,Namba H,Saenko V,Yamashita S

更新日期：2001-11-30 00:00:00

abstract：:An affinity gel containing a newly synthesized derivative of naltrexone, beta-naltrexyl-6-ethylenediamine (NED), was used to purify opioid binding sites by 300-450-fold. Binding sites solubilized from brains of toad, rat and cow using digitonin in the presence of 0.5 M NaCl are retained by the gel and can be eluted wi...

journal_title：Biochemical and biophysical research communications

authors： Gioannini TL,Howard A,Hiller JM,Simon EJ

更新日期：1984-03-15 00:00:00

abstract：:We previously reported transplantation of brain microvascular endothelial cells (MVECs) into cerebral white matter infarction model improved the animal's behavioral outcome by increasing the number of oligodendrocyte precursor cells (OPCs). We also revealed extracellular vesicles (EVs) derived from MVECs promoted surv...

journal_title：Biochemical and biophysical research communications

authors： Osawa S,Kurachi M,Yamamoto H,Yoshimoto Y,Ishizaki Y

更新日期：2017-06-17 00:00:00