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Upregulation of LINC00963 facilitates melanoma progression through miR-608/NACC1 pathway and predicts poor prognosis.

Abstract：

:Long noncoding RNAs (lncRNAs) are acknowledged as crucial regulators involved in multiple pathological processes, including cancer. Although some lncRNAs are studied in melanoma, the association between lncRNA and melanoma progression still remains vague. And the function of LINC00963 in melanoma is waiting for investigation. In this study, upregulated level of LINC00963 in melanoma tissues was observed. Notably, we found DNA copy-number-gain of LINC00963 contributes to its high expression. And high expression of LINC00963 predicts poor prognosis in patients with melanoma. Functional investigation indicated that LINC00963 knockdown dramatically suppressed melanoma cell proliferation, migration and invasion. Mechanistically, we found that LINC00963 could interact with miR-608 while miR-608 could target NACC1. Upregulated LINC00963 led to elevated expression of NACC1 through inhibiting miR-608, which consequently promoted melanoma malignant progression. Taken together, our results illustrated that LINC00963-miR-608-NACC1 pathway might be a potential target for melanoma therapy.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Jiao H,Jiang S,Wang H,Li Y,Zhang W

doi

10.1016/j.bbrc.2018.08.115

subject

Has Abstract

pub_date

2018-09-26 00:00:00

pages

34-39

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)31799-6

journal_volume

504

pub_type

杂志文章

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