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VEGF/CDK2 are involved in diabetic organ regeneration.

Abstract：

AIM/HYPOTHESIS:Diabetes is a hyperglycaemic disease treated by a set of allopathic drugs and natural biomolecules along with many variety of stem cell. We aim to investigate the role of these drugs in targeting common protein molecule in diabetes and its associated disease. We also aim to investigate the organ degeneration mechanistic pathway in diabetes. METHOD:We have generated diabetes using streptozotocin injection and treated them using bone marrow transplantation and curcumin administration. The organs were studied histopathologically and by immunofluorescence analysis while drugs were studied Pharmacogenomically. RESULT:Mice injected with streptozotocin have higher glucose and lower insulin, islet number/diameter, bone marrow cell number compared to control and bone marrow transplanted and curcumin administered mice. Histopathology staining demonstrates damaged morphology of pancreas, kidney, brain and cardiac muscle. Further, upon comparison of all allopathic and ayurvedic drugs used for diabetes several protein targets have been identified by reverse pharmacophore analysis using PharmMapper. VEGF, CDK2, insulin receptor, HSp90, eNOS, Fructose1,6 bisphosphatase, neprilysin, AchE, MAPK are several common protein targets of anti-diabetic drugs. CONCLUSION:This article demonstrates that VEGF and CDK2 are critical marker in organ damage in diabetes as well as organ regeneration.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ambasta RK,Adeshara K,Yadav S,Kumar P

doi

10.1016/j.bbrc.2020.07.014

subject

Has Abstract

pub_date

2020-09-03 00:00:00

pages

1094-1100

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)31396-6

journal_volume

529

pub_type

杂志文章

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