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Calcium mobilization by muscarinic receptors in human astrocytoma cells: measurements with quin 2.

Abstract：

:Activation of muscarinic cholinergic receptors on 1321N1 human astrocytoma cells leads to Ca2+ mobilization as measured by quin 2 fluorescence. Acetylcholine and methacholine were full and potent agonists, while carbachol and muscarine, were fully efficacious but 6- and 10-fold less potent than acetylcholine. The carbachol-induced Ca2+ response was also observed in absence of extracellular Ca2+ and was blocked by muscarinic receptor antagonists but not by organic Ca2+ channel blockers, tetrodotoxin (TTX), tetraethylammonium (TEA) or metal cations, suggesting that Ca2+ is mobilized from intracellular storage sites rather than through plasma membrane ion channels. Muscarinic receptor-mediated Ca2+ release was also detected in kidney epithelial cells but not in rat fibroblasts, glial cells or differentiated neuroblastoma x glioma hybrid cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Noronha-Blob L,Richard C,U'Prichard DC

doi

10.1016/s0006-291x(87)80104-3

subject

Has Abstract

pub_date

1987-08-31 00:00:00

pages

182-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(87)80104-3

journal_volume

147

pub_type

杂志文章

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