Identification and characterization of signal peptide of Mitofusin1 (Mfn1).

abstract：:Tetraheme cytochrome c3 (13 kDa) and flavodoxin (16 kDa), are small electron transfer proteins that have been used to mimic, in vitro, part of the electron-transfer chain that operates between substract electron donors and respiratory electron acceptors partners in Desulfovibrio species (Palma, N., Moura, I., LeGall, ...

journal_title：Biochemical and biophysical research communications

authors： Correia C,Monzani E,Moura I,Lampreia J,Moura JJ

更新日期：1999-03-16 00:00:00

abstract：:Osteoclast activity is enhanced in acidic environments following systemic or local inflammation. However, the regulatory mechanism of receptor activator of NF-κB ligand (RANKL) expression in osteoblasts under acidic conditions is not fully understood. In the present paper, we detected the mRNA expression of the G-prot...

journal_title：Biochemical and biophysical research communications

authors： Okito A,Nakahama K,Akiyama M,Ono T,Morita I

更新日期：2015-03-06 00:00:00

abstract：:Jasmonates are plant lipid-derived oxylipins that act as key signaling compounds in plant immunity, germination, and development. Although some physiological activities of natural jasmonates in mammalian cells have been investigated, their anti-inflammatory actions in mammalian cells remain unclear. Here, we investiga...

journal_title：Biochemical and biophysical research communications

authors： Taki-Nakano N,Kotera J,Ohta H

更新日期：2016-05-13 00:00:00

abstract：:Traditional reconstitution of membrane cytochromes P450 monooxygenase system requires efficient solubilization of both P450 heme enzymes and redox partner NADPH dependent reductase, CPR, either in mixed micellar solution or by incorporation in liposomes. Here we describe a simple alternative approach to assembly of so...

journal_title：Biochemical and biophysical research communications

authors： Grinkova YV,Denisov IG,Sligar SG

更新日期：2010-07-23 00:00:00

abstract：:The chaperonin containing t-complex polypeptide 1 (CCT) is a heterooligomeric molecular chaperone that assists in the folding of actin, tubulin, and other cytosolic proteins. We show here that degradation of CCT in mammalian cells is inhibited by a proteasome-specific inhibitor, lactacystin. When CCT synthesis was inh...

journal_title：Biochemical and biophysical research communications

authors： Yokota S,Kayano T,Ohta T,Kurimoto M,Yanagi H,Yura T,Kubota H

更新日期：2000-12-20 00:00:00

abstract：:The understanding of capsid (C) protein interactions with itself would provide important data on how the core is organized in flaviviruses during assembly. In this study, West Nile (WN) virus C protein was shown to form homodimers using yeast two-hybrid analysis in conjunction with mammalian two-hybrid and in vivo co-...

journal_title：Biochemical and biophysical research communications

authors： Bhuvanakantham R,Ng ML

更新日期：2005-04-01 00:00:00

abstract：:The posttranscriptional RNA editing by the type 1 adenosine deaminase acting on RNAs (ADAR1), expressed as p110 and p150 isoforms, is important for both physiological and pathological processes. Their expression and significance in leukemias remain unknown. Here, we investigated the expression of ADAR1 in Chinese pedi...

journal_title：Biochemical and biophysical research communications

authors： Ma CH,Chong JH,Guo Y,Zeng HM,Liu SY,Xu LL,Wei J,Lin YM,Zhu XF,Zheng GG

更新日期：2011-03-11 00:00:00

abstract：:Recent clinical studies have shown that inorganic arsenic trioxide (As(2)O(3)) at low concentrations induces complete remission with minimal toxicity in patients with refractory acute promyelocytic leukemia (APL). Preclinical studies suggest that As(2)O(3) induces apoptosis and possibly differentiation in APL cells. L...

journal_title：Biochemical and biophysical research communications

authors： Ora I,Bondesson L,Jönsson C,Ljungberg J,Pörn-Ares I,Garwicz S,Pâhlman S

更新日期：2000-10-14 00:00:00

abstract：:Intracellular B(12) metabolism involves a B(12) trafficking chaperone CblC that is well conserved in mammals including human. The protein CblC is known to bind cyanocobalamin (CNCbl, vitamin B(12)) inducing the base-off transition and convert it into an intermediate that can be used in enzyme cofactor synthesis. The b...

journal_title：Biochemical and biophysical research communications

authors： Jeong J,Kim J

更新日期：2011-08-26 00:00:00

abstract：:At an early stage of apoptosis, Jurkat cells transiently become susceptible to binding and phagocytosis by macrophages through the polylactosamine-type carbohydrate chains of CD43 [J. Biol. Chem. 279 (2004) 5967]. Susceptibility of apoptotic Jurkat cells to macrophage recognition was studied over an extended time rang...

journal_title：Biochemical and biophysical research communications

authors： Yamanaka M,Eda S,Beppu M

更新日期：2005-03-04 00:00:00

abstract：:Lung cancer causes high mortality without a declining trend and non small cell lung cancer represents 85% of all pulmonary carcinomas. MicroRNAs (miRNAs) serve as fine regulators of proliferation, migration, invasion/metastasis and angiogenesis of normal and cancer cells. Using TargetScan6.2, we predicted that the ubi...

journal_title：Biochemical and biophysical research communications

authors： Savita U,Karunagaran D

更新日期：2013-05-17 00:00:00

abstract：:5-Lipoxygenase (5LO) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. LTs function in normal host defense, and have pathophysiological roles in chronic inflammatory diseases as asthma and atherosclerosis. Also, possible effects of 5LO product...

journal_title：Biochemical and biophysical research communications

authors： Rådmark O,Samuelsson B

更新日期：2010-05-21 00:00:00

abstract：:In order to study the intracellular regulatory function of glia maturation factor (GMF) in neuronal cells, we achieved a 10-fold overexpression of GMF in the rat pheochromocytoma cell line PC12 by infection with a replication-defective human adenovirus carrying a rat GMF cDNA insert. These cells showed a 3.6-fold incr...

journal_title：Biochemical and biophysical research communications

authors： Zaheer A,Lim R

更新日期：1998-09-18 00:00:00

abstract：:Yeast cells adapted to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) exhibit a plasma membrane less susceptible to 2,4-D-induced disruption and are more tolerant than unadapted cells to lethal concentrations of the herbicide. These cells, adapted to grow in the presence of increasing concentrations of 2,4-D, we...

journal_title：Biochemical and biophysical research communications

authors： Viegas CA,Cabral MG,Teixeira MC,Neumann G,Heipieper HJ,Sá-Correia I

更新日期：2005-04-29 00:00:00

abstract：:The effects of substance P on cultured rabbit osteoclasts were investigated. The intracellular Ca(2+) concentration ([Ca(2+)](i)) which was monitored by the microfluorometric technique using fura-2, in osteoclasts elevated by the addition of substance P (0.3-5 microM). The EC(50) value of substance P was about 200 nM....

journal_title：Biochemical and biophysical research communications

authors： Mori T,Ogata T,Okumura H,Shibata T,Nakamura Y,Kataoka K

更新日期：1999-08-27 00:00:00

abstract：:Nuclear migration in Arabidopsis root hairs is bidirectional and relies on actin filaments. However, how actin filaments regulate the bidirectional movement of nuclei remains unclear. Here, we discovered that nuclei migrate forward and backward according to the developmental stage of the hair cells. In addition, the m...

journal_title：Biochemical and biophysical research communications

authors： Zhang S,Liu J,Xue X,Tan K,Wang C,Su H

更新日期：2019-11-19 00:00:00

abstract：:Peroxynitrite, formed by the interaction of superoxide with nitric oxide, has previously been implicated mostly as a cytotoxic agent. In contrast, its physiological and, possibly, beneficial effects are largely unknown. We have previously shown [Journal of Biological Chemistry, 1997, 272, 7253] that RAW 264.7 macropha...

journal_title：Biochemical and biophysical research communications

authors： Scivittaro V,Boggs S,Mohr S,Lapetina EG

更新日期：1997-12-08 00:00:00

abstract：:There is increasing evidence that a functional interaction exists between interleukin-1beta (IL-1beta) and N-methyl-D-aspartate (NMDA) receptors. The present study attempted to elucidate the effect of IL-1beta on the NMDA-induced outward currents in mechanically dissociated hippocampal neurons using a perforated patch...

journal_title：Biochemical and biophysical research communications

authors： Zhang R,Yamada J,Hayashi Y,Wu Z,Koyama S,Nakanishi H

更新日期：2008-08-08 00:00:00

abstract：:Transglutaminase inhibitor (1,3,4,5-tetramethyl-2-[(2-oxopropyl)thio]imidazolium chloride or L-682777) affected the appearance of the fertilization envelope (FE) and subsequent development in Sphaerechinus granularis and Arbacia punctulata in a concentration-dependent manner. Abnormalities were first visible in formin...

journal_title：Biochemical and biophysical research communications

authors： Cariello L,Zanetti L,Lorand L

更新日期：1994-11-30 00:00:00

abstract：:In addition to a role in translation, AIMP1 is secreted to affect various immune cells, such as macrophages, dendritic cells, B cells, and natural killer cells. However, the direct effects of AIMP1 on T cells have not yet been reported. In this study, we investigated whether AIMP1 could modulate T cell responses direc...

journal_title：Biochemical and biophysical research communications

authors： Kim MS,Lee A,Cho D,Kim TS

更新日期：2019-06-30 00:00:00

abstract：:Rbx1 and Rbx2 are essential components of Cullin-RING E3 Ligases. Vif is generally believed to preferentially recruit the Cul5-Rbx2 module to induce proteasomal degradation of antiretroviral enzyme APOBEC3G, although some investigators have found that the Cul5-Rbx1 module is recruited. Here, to investigate the functio...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Wang X,Wang W,Zhang J,Wang J,Wang C,Lv M,Zuo T,Liu D,Zhang H,Wu J,Yu B,Kong W,Wu H,Yu X

更新日期：2015-06-12 00:00:00

abstract：:Somatic mutations of the fibroblast growth factor receptor 3 (FGFR3) gene were detected by peptide nucleic acid (PNA)-mediated real-time PCR clamping. Mutation was detected in negative control containing only wild-type DNA due to a misincorporation of dNTPs to PNA binding sites when the amount of template DNA was decr...

journal_title：Biochemical and biophysical research communications

authors： Miyake M,Sugano K,Kawashima K,Ichikawa H,Hirabayashi K,Kodama T,Fujimoto H,Kakizoe T,Kanai Y,Fujimoto K,Hirao Y

更新日期：2007-11-03 00:00:00

abstract：:Innate immune cells respond to microbial invaders using pattern recognition receptors that detect conserved microbial patterns. Among the cellular processes stimulated downstream of pattern recognition machinery is the initiation of autophagy, which plays protective roles against intracellular microbes. We have shown ...

journal_title：Biochemical and biophysical research communications

authors： Pflaum K,Gerdes K,Yovo K,Callahan J,Snyder ML

更新日期：2012-06-08 00:00:00

abstract：:Using a novel method consisting of chromatin fractionation and allele-specific detection, chromatin packaging is compared between active X (Xa) and inactive X (Xi) chromosomes for five tumor cell clones that were derived from inter-subspecific F1 female mice. Separation of heterochromatic (H) and euchromatic (E) fract...

journal_title：Biochemical and biophysical research communications

authors： Endo Y,Watanabe T,Kuwabara K,Tsunashima K,Mishima Y,Arakawa M,Takagi N,Kominami R

更新日期：1998-03-06 00:00:00

abstract：:We have previously identified the region containing transcriptional enhancer in mouse immunoglobulin heavy chain (IgH) gene as an initiation region of DNA replication. The octamer sequence therein has been found to be essential for initiation of DNA replication as well as for transcription. Octamer-binding protein fam...

journal_title：Biochemical and biophysical research communications

authors： Ogawa N,Ariga H,Iguchi-Ariga SM

更新日期：1994-05-16 00:00:00

abstract：:Cisplatin plays a key role in treating small cell lung cancer (SCLC); however, the rapid development of cisplatin resistance limits its treatment effect. The detailed mechanisms of cisplatin-resistance, particularly in SCLC, remain unclear. We analyzed the differentially expressed genes (DEGs) between cisplatin-resist...

journal_title：Biochemical and biophysical research communications

authors： Ma K,Li S,Huo X,Guo M,Du X,Li C,Liu X,Lv J,Chen Z

更新日期：2020-12-10 00:00:00

abstract：:Members of the T cell Ig and mucin (TIM) family have recently been implicated in the control of T cell-mediated immune responses. In this study, we found TIM-1 expression on anti-IgM- or anti-CD40-stimulated splenic B cells, which was further up-regulated by the combination of anti-IgM and anti-CD40 Abs. On the other ...

journal_title：Biochemical and biophysical research communications

authors： Ma J,Usui Y,Takeda K,Harada N,Yagita H,Okumura K,Akiba H

更新日期：2011-03-11 00:00:00

abstract：:Colorectal cancer is one of the most common malignant tumors worldwide with rising incidence. MicroRNAs are small non-coding RNAs that implicate in multiple physiological or pathological processes. The aberrant expression of miRNA-215 (miR-215) has been illustrated in various types of cancers. However, the expression ...

journal_title：Biochemical and biophysical research communications

authors： Chen Z,Han S,Huang W,Wu J,Liu Y,Cai S,He Y,Wu S,Song W

更新日期：2016-10-21 00:00:00

abstract：:Recently, a high number of copper derivatives has been evaluated as DNA-targeting metallodrugs, due to the lower toxicity and its potential to cleave DNA. Several strategies have been testing to develop metal compounds effective against tumour cells. In this work, the ternary copper (doxycycline)-(1,10-phenanthroline)...

journal_title：Biochemical and biophysical research communications

authors： Lopes JC,Botelho FV,Barbosa Silva MJ,Silva SF,Polloni L,Alves Machado PH,Rodrigues de Souza T,Goulart LR,Silva Caldeira PP,Pereira Maia EC,Morelli S,de Oliveira-Júnior RJ

更新日期：2020-12-17 00:00:00

abstract：:Human thymidine phosphorylase (dThdPase) is thought to be identical to an angiogenesis factor, platelet-derived endothelial cell growth factor (PD-ECGF). However, the whole amino acid sequence of dThdPase is still unknown. N-terminal amino acid sequencing of dThdPase isolated from human placenta gave the sequence Ac-A...

journal_title：Biochemical and biophysical research communications

authors： Miyadera K,Dohmae N,Takio K,Sumizawa T,Haraguchi M,Furukawa T,Yamada Y,Akiyama S

更新日期：1995-07-26 00:00:00