AIMP1 regulates TCR signaling and induces differentiation of regulatory T cells by interfering with lipid raft association.

Abstract:

:In addition to a role in translation, AIMP1 is secreted to affect various immune cells, such as macrophages, dendritic cells, B cells, and natural killer cells. However, the direct effects of AIMP1 on T cells have not yet been reported. In this study, we investigated whether AIMP1 could modulate T cell responses directly. Results revealed that AIMP1 significantly inhibited T cell receptor (TCR)-dependent activation and proliferation of CD4 T cells, as well as decreased TCR stimuli-induced Ca2+ influx in CD4 T cells. In addition, microscopic analysis revealed that lipid raft association in response to TCR engagement was significantly reduced in the presence of AIMP1, and the phosphorylation of PLCγ and PI3K was also down-regulated in CD4 T cells by AIMP1. Furthermore, AIMP1 specifically enhanced the differentiation of regulatory T (Treg) cells, while it had no effect on T helper type 1 (Th1), type 2 (Th2), and type 17 (Th17) cell differentiation. Collectively, these results indicate that AIMP1 affects T cells directly by down-regulating TCR signaling complex formation and inducing Treg cell differentiation in CD4 T cells.

authors

Kim MS,Lee A,Cho D,Kim TS

doi

10.1016/j.bbrc.2019.05.040

subject

Has Abstract

pub_date

2019-06-30 00:00:00

pages

875-880

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(19)30909-X

journal_volume

514

pub_type

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