Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells.

abstract：:We generated two transgenic mice carrying the adenovirus type 12 E1 region genes under control of the human renin promoter, in which the E1A and E1B genes were expressed predominantly in the kidney. Interestingly, renal transcription of the gene for mouse renin was shown to be elevated at 28 and 40 folds as compared i...

journal_title：Biochemical and biophysical research communications

authors： Fukamizu A,Sagara M,Sugiyama F,Yagami K,Murakami K

更新日期：1994-02-28 00:00:00

abstract：:We have recently shown that optimal growth temperature (T(opt)) is one of the factors that influence genomic GC in prokaryotes. Our results have been disputed by Marashi and Ghalanbor, who claim that the correlations we show are not "robust" because the elimination of some points (arbitrarily chosen) leads, in some fa...

journal_title：Biochemical and biophysical research communications

authors： Musto H,Naya H,Zavala A,Romero H,Alvarez-Valin F,Bernardi G

更新日期：2005-05-06 00:00:00

abstract：:The bacterioferritin-associated ferredoxin (Bfd) of Escherichia coli is a 64-residue polypeptide encoded by the bfd gene located upstream of the gene (bfr) encoding the iron-storage haemoprotein, bacterioferritin. The Bfd sequence resembles those of the approximately 60-residue domains found in NifU proteins (required...

journal_title：Biochemical and biophysical research communications

authors： Quail MA,Jordan P,Grogan JM,Butt JN,Lutz M,Thomson AJ,Andrews SC,Guest JR

更新日期：1996-12-13 00:00:00

abstract：:An E. coli mutant deficient in organophosphonate biodegradation has been complemented with a cosmid library prepared from a BamHI partial digest of wild-type E. coli W3110. Mutant E. coli SL724, when transformed with cosmid pSL163 and plasmid pSL263, regained the ability to exploit ethylphosphonate as a sole source of...

journal_title：Biochemical and biophysical research communications

authors： Loo SH,Peters NK,Frost JW

更新日期：1987-10-14 00:00:00

abstract：:The specificity of alpha, beta-methylene-ATP for P2X receptor binding sites in the CNS has been examined by testing the effects of several ATP analogues and other ATP-related substances on the binding of 10 nM [3H]alpha,beta-methylene-ATP to 20 microns thick sections of fresh-frozen rat brain. The labelling of the put...

journal_title：Biochemical and biophysical research communications

authors： Worthington RA,Hansen MA,Bennett MR,Barden JA,Balcar VJ

更新日期：1998-08-10 00:00:00

abstract：:We have recently observed that attomolar concentration of exogenously added TGF beta, a molecule structurally related to inhibin, can stimulate the basal secretion of FSH in a pituitary cell culture. Inhibin purified from porcine follicular fluid antagonizes this activity of TGF beta. To understand further the homeost...

journal_title：Biochemical and biophysical research communications

authors： Ying SY,Becker A,Ling N,Ueno N,Guillemin R

更新日期：1986-05-14 00:00:00

abstract：:Temozolomide (TMZ) is a methylating agent used in chemotherapy against glioblastoma. This work was designed to clarify details in repair pathways acting to remove DNA double-strand breaks (DSBs) induced by TMZ. Cultured mouse embryonic fibroblasts were used which were deficient in DSB repair genes such as homologous r...

journal_title：Biochemical and biophysical research communications

authors： Kondo N,Takahashi A,Mori E,Ohnishi K,McKinnon PJ,Sakaki T,Nakase H,Ohnishi T

更新日期：2009-10-02 00:00:00

abstract：:To study polygenetically inherited human diseases like hypertension, inbred rat strains are usually the preferred models. Because many inbred generations under optimized environmental conditions may have led to the survival of "silent" disease genes, we used a cross between one wild rat and genetically hypertensive SH...

journal_title：Biochemical and biophysical research communications

authors： Klöting I,Kovács P,van den Brandt J

更新日期：2001-06-29 00:00:00

abstract：:The family C G protein-coupled receptor (GPCR) T1R2 and T1R3 heterodimer functions as a broadly acting sweet taste receptor. Perception of sweet taste is a species-dependent physiological process. It has been widely reported that New World monkeys and rodents are not able to perceive some of the artificial sweeteners ...

journal_title：Biochemical and biophysical research communications

authors： Liu B,Ha M,Meng XY,Khaleduzzaman M,Zhang Z,Li X,Cui M

更新日期：2012-10-19 00:00:00

abstract：:Peroxynitrite, formed by the interaction of superoxide with nitric oxide, has previously been implicated mostly as a cytotoxic agent. In contrast, its physiological and, possibly, beneficial effects are largely unknown. We have previously shown [Journal of Biological Chemistry, 1997, 272, 7253] that RAW 264.7 macropha...

journal_title：Biochemical and biophysical research communications

authors： Scivittaro V,Boggs S,Mohr S,Lapetina EG

更新日期：1997-12-08 00:00:00

abstract：:After parallel hybridization to complementary template RNA, alpha-anomeric oligonucleotides are not primers for Moloney murine leukemia virus reverse transcriptase. As can be expected they are competitors of classical primer oligonucleotides (beta-anomeric). They therefore inhibit the RNA dependent DNA polymerase acti...

journal_title：Biochemical and biophysical research communications

authors： Lavignon M,Bertrand JR,Rayner B,Imbach JL,Malvy C,Paoletti C

更新日期：1989-06-30 00:00:00

abstract：:Ubiquitin specific protease 39 (USP39) is one of the deubiquitinating enzymes without ubiquitin protease activity, which has been implicated in the progression of several cancers. However, the role of USP39 in pancreatic cancer (PC) is largely unknown. In present study, we found that USP39 expression was elevated in P...

journal_title：Biochemical and biophysical research communications

authors： Cai J,Liu T,Huang P,Yan W,Guo C,Xiong L,Liu A

更新日期：2017-04-22 00:00:00

abstract：:Considering the number of cytosolic proteins associated with many diseases, development of cytosol-penetrating molecules from outside of living cells is highly in demand. To gain access to the cytosol after cellular uptake, cell-penetrating molecules should be released from intermediate endosomes prior to the lysosoma...

journal_title：Biochemical and biophysical research communications

authors： Kim JS,Choi DK,Park SW,Shin SM,Bae J,Kim DM,Yoo TH,Kim YS

更新日期：2015-11-27 00:00:00

abstract：:Myocardial fibrosis is the pathological consequence of injury-induced fibroblastto-myofibroblast transition, resulting in increased stiffness and diminished cardiac function. Histone modification has been shown to play an important role in the pathogenesis of cardiac fibrosis. Here, we identified H3K27me3 demethylase ...

journal_title：Biochemical and biophysical research communications

authors： Long F,Wang Q,Yang D,Zhu M,Wang J,Zhu Y,Liu X

更新日期：2020-08-06 00:00:00

abstract：:In RBL-2H3 rat basophilic leukemia cells, Fc epsilon R1 crosslinking by multivalent antigen stimulates phosphatidylinositol (PI) turnover and Ca2+ influx and causes functional responses that include secretion, membrane ruffling and actin polymerization. Here, we show that the tyrosine kinase inhibitor, genistein, inhi...

journal_title：Biochemical and biophysical research communications

authors： Deanin GG,Martinez AM,Pfeiffer JR,Gardner ME,Oliver JM

更新日期：1991-08-30 00:00:00

abstract：:More than 85% of c-myc transcription is controlled by the nuclease hypersensitive element III(1) upstream of the P1 promoter of this oncogene. The purine-rich sequence in the anti-sense strand forms a G-quadruplex, which has been recently implicated in colorectal cancer, and is proposed as a silencer element [Proc. Na...

journal_title：Biochemical and biophysical research communications

authors： Mathur V,Verma A,Maiti S,Chowdhury S

更新日期：2004-08-06 00:00:00

abstract：:The susceptibility to hydrolysis of LHRH and the decapeptide analogue Antide has been compared. The hydrolysis of LHRH by pig kidney brush border membranes is inhibited by phosphoramidon (I50 = 5.6 nM) implicating endopeptidase-24.11 in the initiation of hydrolysis. Under conditions in which LHRH is fully degraded by ...

journal_title：Biochemical and biophysical research communications

authors： Medeiros Mdos S,Turner AJ,Ljungqvist A,Folkers K

更新日期：1991-04-15 00:00:00

abstract：:An insect antiviral compound was purified from Heliothis virescens larval hemolymph by gel-filtration high pressure liquid chromatography (HPLC) and C-18 reverse-phase HPLC and its structure was determined by mass spectrometry. The antiviral compound is an N-myristoylated-peptide containing six amino acids with calcul...

journal_title：Biochemical and biophysical research communications

authors： Ourth DD

更新日期：2004-07-16 00:00:00

abstract：:Cav1.2 (alpha1C) and Cav1.3 (alpha1D) L-type Ca channels are co-expressed in the heart. To date, there are no pharmacological or biophysical tools to separate alpha1D from alpha1C Ca currents (I(Ca-L)) in cardiomyocytes. Here, we established a physiological model to study alpha1D I(Ca-L) in native myocytes using RNA i...

journal_title：Biochemical and biophysical research communications

authors： Karnabi E,Qu Y,Mancarella S,Yue Y,Wadgaonkar R,Boutjdir M

更新日期：2009-07-10 00:00:00

abstract：:Tumor necrosis factor receptor-associated factor 2 (TRAF2) has been demonstrated that it plays a significant role in cell death receptor signal transduction. The purpose of this study was to investigate the expression of TRAF2 and its possible role in FJOA. We observed an up-regulation of TRAF2 in FJOA by immunohistoc...

journal_title：Biochemical and biophysical research communications

authors： Jiang J,Zhang J,Wu C,Guo X,Chen C,Bao G,Sun Y,Chen J,Xue P,Xu G,Cui Z

更新日期：2018-09-10 00:00:00

abstract：:Aberrant activation of Notch signaling frequently occurs in liver cancer, and is associated with liver malignancies. However, the mechanisms regulating pathologic Notch activation in hepatocellular carcinoma (HCC) remain unclear. Protein O-fucosyltransferase 1 (Pofut1) catalyzes the addition of O-linked fucose to the ...

journal_title：Biochemical and biophysical research communications

authors： Ma L,Dong P,Liu L,Gao Q,Duan M,Zhang S,Chen S,Xue R,Wang X

更新日期：2016-04-29 00:00:00

abstract：:Hartnup disorder is an autosomal recessive phenotype involving a transporter for monoamino-monocarboxylic acids. Genetic analysis of the mouse model mapped its locus to human chromosome 11q13 (8). We report here the results of linkage analysis in two Japanese first cousin-marriage families. In the first family, the pr...

journal_title：Biochemical and biophysical research communications

authors： Nozaki J,Dakeishi M,Ohura T,Inoue K,Manabe M,Wada Y,Koizumi A

更新日期：2001-06-08 00:00:00

abstract：:The aim of the present study was to accomplish de novo generation of reconstituted human skin with enriched hair follicles. Dermal papillae (DP) are known to play a crucial organizing role in hair follicle induction. However, generation of enriched human hair follicles using cultured DP cells has not been accomplished...

journal_title：Biochemical and biophysical research communications

authors： Yoshida Y,Soma T,Matsuzaki T,Kishimoto J

更新日期：2019-08-27 00:00:00

abstract：:A homodimeric protein designated quinqueginsin, with a molecular weight of 53 kDa, has been isolated from the roots of American ginseng Panax quinquefolium. It was unadsorbed on DEAE cellulose in low ionic strength and neutral pH, and adsorbed on Affigel blue gel and SP-Sepharose under similar conditions. Its N-termin...

journal_title：Biochemical and biophysical research communications

authors： Wang HX,Ng TB

更新日期：2000-03-05 00:00:00

abstract：:In order to investigate the utility of intranasal administration of peptides for systemic medication, the nasal absorption of the model peptide, leucine enkephalin (Tyr-Gly-Gly-Phe-Leu), was studied in the rat. At a concentration of 60 micrograms/ml in Ringer's buffer the pentapeptide was found to undergo, extensive h...

journal_title：Biochemical and biophysical research communications

authors： Hussain A,Faraj J,Aramaki Y,Truelove JE

更新日期：1985-12-31 00:00:00

abstract：:Various dehydrogenation polymers (the so-called synthetic lignins) were synthesized from four different phenylpropenoids by endwise and bulk polymerizations and investigated for their anti-influenza virus activity. All of these materials suppressed the plaque formation of influenza virus infecting MDCK cells and the R...

journal_title：Biochemical and biophysical research communications

authors： Sakagami H,Nagata K,Ishihama A,Oh-hara T,Kawazoe Y

更新日期：1990-11-15 00:00:00

abstract：:DMBA-induced rat mammary tumors were used to study the possible association of phosphoinositide phosphorylation to tumor growth. These membranous enzymatic activities were measured during various stages of tumor growth induced by pharmacological manipulation of plasma prolactin level. An increase in phosphorylation of...

journal_title：Biochemical and biophysical research communications

authors： Sharoni Y,Teuerstein I,Levy J

更新日期：1986-01-29 00:00:00

abstract：:Previously, we reported that CARM1 undergoes ubiquitination-dependent degradation in renal podocytes. It was also reported that CARM1 is necessary for fasting-induced hepatic gluconeogenesis. Based on these reports, we hypothesized that treatment with insulin, a hormone typically present under the 'fed' condition, wou...

journal_title：Biochemical and biophysical research communications

authors： Yeom CG,Kim DI,Park MJ,Choi JH,Jeong J,Wi A,Park W,Han HJ,Park SH

更新日期：2015-06-05 00:00:00

abstract：:Steroid 11 beta-hydroxylase deficiency (11 beta OHD) is derived from mutations in the P45011 beta gene (CYP11B1) and inherited in an autosomal recessive manner. In the present study, we have performed a molecular genetic analysis of CYP11B1 in a Japanese patient clinically diagnosed as classic 11 beta OHD. Nucleotide ...

journal_title：Biochemical and biophysical research communications

authors： Yang LX,Toda K,Miyahara K,Nomoto S,Kinoshita E,Baba T,Yoshimoto M,Araki K,Kurashige T,Hashimoto K

更新日期：1995-11-13 00:00:00

abstract：:Endothelin-1 acts as a potent autocrine and paracrine mediator in the kidney. Glomeruli and renal arterioles also express functional thrombin receptors which mediate the cellular effects of thrombin. Using the binding on glomerular epithelial cells of 125I-labeled ATAP2, a monoclonal antibody raised against the functi...

journal_title：Biochemical and biophysical research communications

authors： Chen X,Berrou J,Nguyen G,Sraer JD,Rondeau E

更新日期：1995-12-14 00:00:00