Tyrosine kinase-dependent phosphatidylinostiol turnover and functional responses in the Fc epsilon R1 signalling pathway.

abstract：:We previously reported transplantation of brain microvascular endothelial cells (MVECs) into cerebral white matter infarction model improved the animal's behavioral outcome by increasing the number of oligodendrocyte precursor cells (OPCs). We also revealed extracellular vesicles (EVs) derived from MVECs promoted surv...

journal_title：Biochemical and biophysical research communications

authors： Osawa S,Kurachi M,Yamamoto H,Yoshimoto Y,Ishizaki Y

更新日期：2017-06-17 00:00:00

abstract：:Infrared spectra of E. coli strain JM103 and transformants which overproduced recombinant proinsulin have been measured as a function of pressure up to 38 kbar. It is the first time that high-pressure infrared spectra of live bacteria have been successfully measured. In ambient conditions, spectra of the host strain J...

journal_title：Biochemical and biophysical research communications

authors： Wong PT,Zahab DM,Narang SA,Sung WL

更新日期：1987-07-15 00:00:00

abstract：:Ubiquitin carboxyl-terminal hydrolases (UCHs) are implicated in the proteolytic processing of polymeric ubiquitin. We have isolated a novel mouse gene for ubiquitin carboxyl-terminal hydrolase isozyme L4. The gene named Uchl4 encodes a novel member of the family of ubiquitin carboxyl-terminal hydrolases (UCHs) whose p...

journal_title：Biochemical and biophysical research communications

authors： Osawa Y,Wang YL,Osaka H,Aoki S,Wada K

更新日期：2001-05-11 00:00:00

abstract：:To assess laser modulation of wound healing, full-thickness cutaneous wounds were produced in the backs of pigs, and subjected to treatment with helium-neon laser. For comparison, some wounds were treated with non-laser energy source (a tungsten light) or left untreated as controls. Type I and type III procollagen mRN...

journal_title：Biochemical and biophysical research communications

authors： Saperia D,Glassberg E,Lyons RF,Abergel RP,Baneux P,Castel JC,Dwyer RM,Uitto J

更新日期：1986-08-14 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) Tat is a virally encoded protein that dramatically up-regulates viral replication through interactions with the HIV-1 5' long terminal repeat (LTR) and cellular transcription factors. The HIV-1 LTR is divided into three major regions: modulatory, core and TAR. The modula...

journal_title：Biochemical and biophysical research communications

authors： Li X,Josef J,Marasco WA

更新日期：2001-08-24 00:00:00

abstract：:PRA1 (prenylated Rab acceptor) is a general regulator of Rab proteins, while RILP (Rab interacting lysosomal protein) is a specific effector for Rab7. It has been shown that PRA1 interacts with Rab proteins and with VAMP2. Therefore PRA1 is probably an important factor for membrane traffic, linking together the functi...

journal_title：Biochemical and biophysical research communications

authors： Bucci C,De Gregorio L,Bruni CB

更新日期：2001-08-31 00:00:00

abstract：:Macrophages in tumor are mostly M2-polarized and have been reported to promote tumorigenesis, which are also defined as tumor-associated macrophages (TAMs). β-elemene has therapeutic effects against several cancers, however, it remains unknown whether β-elemene could inhibit cancer by targeting TAMs. Herein, we examin...

journal_title：Biochemical and biophysical research communications

authors： Yu X,Xu M,Li N,Li Z,Li H,Shao S,Zou K,Zou L

更新日期：2017-08-19 00:00:00

abstract：:Growing evidence indicates that endoplasmic reticulum (ER) stress and/or ER stress-mediated apoptosis may play a role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. The present study investigated the effects of non-cytotoxic concentrations of nitric oxide (NO) and nitrite, a metabolite ...

journal_title：Biochemical and biophysical research communications

authors： Jeong SO,Son Y,Lee JH,Choi SW,Kim SH,Cheong YK,Chung HT,Pae HO

更新日期：2017-11-04 00:00:00

abstract：:In myotonic dystrophy type I (DM1), nuclear retention of mutant DMPK transcripts compromises muscle cell differentiation. Although several reports have identified molecular defects in myogenesis, it remains still unclear how exactly the retention of the mutant transcripts induces this defect. We have recently created ...

journal_title：Biochemical and biophysical research communications

authors： Mastroyiannopoulos NP,Chrysanthou E,Kyriakides TC,Uney JB,Mahadevan MS,Phylactou LA

更新日期：2008-12-12 00:00:00

abstract：:Mitochondrial pyruvate carrier (MPC), composed of MPC1 and MPC2, can modulate pyruvate oxidation in mitochondrial and MPC1 expression correlates with poor prognosis of multiple cancers. Here, we reported that MPC1 is acetylated and its main acetylation sites are: K45 and K46. Sirt3 binds to and deacetylates MPC1. High...

journal_title：Biochemical and biophysical research communications

authors： Liang L,Li Q,Huang L,Li D,Li X

更新日期：2015-12-25 00:00:00

abstract：:Certain PKC isoforms are stimulated by insulin and interact with IR as well as with IRS, but it is still not clear if specific PKC isoforms regulate IR signaling directly or through IRS-1. PKCalpha may regulate IRS activity in response to insulin. We investigated the possibility that PKCalpha may be important in insul...

journal_title：Biochemical and biophysical research communications

authors： Cipok M,Aga-Mizrachi S,Bak A,Feurstein T,Steinhart R,Brodie C,Sampson SR

更新日期：2006-06-30 00:00:00

abstract：BACKGROUND:When an activated muscle is rapidly stretched, force rises and peaks while muscle lengthens. The peak force is normally called critical-force (Pc). The mechanism behind this increase in force is not well understood, but it has been associated with crossbridges operating in different states. METHODS:Myofibri...

journal_title：Biochemical and biophysical research communications

authors： Minozzo FC,Altman D,Rassier DE

更新日期：2015-08-07 00:00:00

abstract：:Autophagy is a biological recycling process via the self-digestion of organelles, proteins, and lipids for energy-consuming differentiation and homeostasis. The Golgi serves as a donor of the double-membraned phagophore for autophagosome assembly. In addition, recent studies have demonstrated that pulmonary and hepati...

journal_title：Biochemical and biophysical research communications

authors： Park S,Kim S,Kim MJ,Hong Y,Lee AY,Lee H,Tran Q,Kim M,Cho H,Park J,Kim KP,Park J,Cho MH

更新日期：2018-01-01 00:00:00

abstract：:In the present study, we demonstrated that Ang II provokes a transitory enhancement of focal adhesion kinase (FAK) and paxillin phosphorylation in human umbilical endothelial cells (HUVEC). Moreover, Ang II induces a time- and dose-dependent augmentation in cell migration, but does not affect HUVEC proliferation. The ...

journal_title：Biochemical and biophysical research communications

authors： Montiel M,de la Blanca EP,Jiménez E

更新日期：2005-02-25 00:00:00

abstract：:Prostaglandins (PGs) released by cultured rat Kupffer cells in response to stimulation with lipopolysaccharide (LPS) or ethanol were extracted from culture media, separated by HPLC and measured by radioimmunoassay. LPS (0.5-5 micrograms/ml) enhanced, after a 3-4 hrs lag period, the production of PGE2 (7-10 fold by 24 ...

journal_title：Biochemical and biophysical research communications

authors： Victorov AV,Hoek JB

更新日期：1995-10-13 00:00:00

abstract：:Vasodilator-stimulated phosphoprotein (VASP) is an actin regulatory protein that functions in adhesion and migration. In epithelial cells, VASP participates in cell-cell adhesion. At the molecular level, VASP drives actin bundling and polymerization. VASP activity is primarily regulated by phosphorylation. Three physi...

journal_title：Biochemical and biophysical research communications

authors： Thomson DM,Ascione MP,Grange J,Nelson C,Hansen MD

更新日期：2011-10-14 00:00:00

abstract：:Rat intoxication with a single dose of the hepatotoxin carbon tetrachloride induces a significant modification of liver protein kinase C total activity which depends on the degree of the intrahepatocyte oxidative unbalance provoked by various concentrations of the haloalkane. Low carbon tetrachloride amounts stimulate...

journal_title：Biochemical and biophysical research communications

authors： Pronzato MA,Domenicotti C,Rosso E,Bellocchio A,Patrone M,Marinari UM,Melloni E,Poli G

更新日期：1993-07-30 00:00:00

abstract：:To investigate molecular mechanisms linking inflammation with neurodegeneration, we treated neuronal cultures with prostaglandins (PGs), which are mediators of inflammation. PGA1, D2, J2, and Delta12-PGJ2, but not PGE2, reduced the viability and raised the levels of ubiquitinated proteins in the neuronal cells. PGJ2 a...

journal_title：Biochemical and biophysical research communications

authors： Li Z,Melandri F,Berdo I,Jansen M,Hunter L,Wright S,Valbrun D,Figueiredo-Pereira ME

更新日期：2004-07-09 00:00:00

abstract：:In isolated rabbit proximal tubules the addition of 2.0 microM but not 0.2 microM ionomycin induced a sustained increase in cell pH ([pH]i). This [pH]i response to 2.0 microM ionomycin was shown to be independent of several transporters such as Na+/H+ exchanger, Na(+)-HCO3- cotransporter, Cl-/HCO3- exchanger, or H(+)-...

journal_title：Biochemical and biophysical research communications

authors： Yamada H,Seki G,Taniguchi S,Uwatoko S,Suzuki K,Kurokawa K

更新日期：1996-08-05 00:00:00

abstract：:Telmisartan, an angiotensin II type 1 receptor blocker (ARB), attenuates hyperglycemia-aggravated vascular inflammation by decreasing IκB kinase β (IKKβ) expression in endothelial cells. Because glycogen synthase 3β (GSK3β) is involved in inflammatory process by regulating nuclear factor-κB (NF-κB) activity, we invest...

journal_title：Biochemical and biophysical research communications

authors： Song KH,Bae SJ,Chang J,Park JH,Jo I,Cho KW,Cho DH

更新日期：2017-09-30 00:00:00

abstract：:We investigated the capacity of K-252a, an inhibitor of rat brain protein kinase C (PKC), to influence polymorphonuclear neutrophil (PMN) PKC and PMN activation with chemically and structurally dissimilar agonists. K-252a inhibited PMN PKC (IC50 = 0.58 microM), and caused a concentration-dependent (0.1-10 microM) inhi...

journal_title：Biochemical and biophysical research communications

authors： Smith RJ,Justen JM,Sam LM

更新日期：1988-05-16 00:00:00

abstract：:v-Src activates gene expression mediated by serum response elements (SREs) and TPA response elements (TREs). v-Src-induced SRE- and TRE-mediated gene expressions are both dependent upon HaRas. Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that has been implicated in v-Src-initiated signals. We report...

journal_title：Biochemical and biophysical research communications

authors： Gupta R,Foster DA

更新日期：1994-12-15 00:00:00

abstract：:Angiotensin II (Ang II), one of the main vasoactive hormones of the renin-angiotensin system, contributes to the development and progression of atherosclerosis by inducing vascular smooth muscle cells (VSMCs) migration. Although previous studies have shown that Ang II upregulates low density lipoprotein receptor-relat...

journal_title：Biochemical and biophysical research communications

authors： Jung HO,Uhm JS,Seo SM,Kim JH,Youn HJ,Baek SH,Chung WS,Seung KB

更新日期：2010-11-26 00:00:00

abstract：:Aldosterone is synthesized in the adrenal by the aldosterone synthase CYP11B2. Although the control of CYP11B2 expression is important to maintain the mineral homeostasis, its overexpression induced by the depolarization-induced calcium (Ca2+) signaling activation has been reported to increase the synthesis of aldoste...

journal_title：Biochemical and biophysical research communications

authors： Ito R,Morita M,Nakano T,Sato I,Yokoyama A,Sugawara A

更新日期：2021-01-01 00:00:00

abstract：:Under nitrosative stressed condition intracellular GSNO accumulation is common to all cell types. Conserved NADH-dependent GSNO reductase was reported previously as an important cellular protective measure against this. In spite of the constitutive nature of the enzyme, we observed in vivo inactivation of two importan...

journal_title：Biochemical and biophysical research communications

authors： Sahoo R,Sengupta R,Ghosh S

更新日期：2003-03-21 00:00:00

abstract：:Osteoclasts are hematopoietic cells essential for bone resorption. To understand the process of osteoclastogenesis, we have developed a culture system that employs a stromal cell line, in which differentiation of osteoclasts from single embryonic stem (ES) cells occurs. This culture, which did not require any cell pas...

journal_title：Biochemical and biophysical research communications

authors： Hemmi H,Okuyama H,Yamane T,Nishikawa S,Nakano T,Yamazaki H,Kunisada T,Hayashi S

更新日期：2001-01-19 00:00:00

abstract：:Special AT-rich sequence-binding protein (SATB) plays a critical role in bone generation and osteoblast differentiation. In the present study, the differentially expressed genes by SATB2 overexpression were analyzed in MC3T3-E1 osteoblast-like cells using Alizarin red S staining, wound healing assay and Agilent's Huma...

journal_title：Biochemical and biophysical research communications

authors： Kim IS,Jeong SJ,Kim SH,Jung JH,Park YG,Kim SH

更新日期：2012-01-13 00:00:00

abstract：:Signal regulatory protein α (SIRPα) is a transmembrane protein that binds the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic region and is abundantly expressed on dendritic cells and macrophages. Wild-type (WT) C57BL/6 mice are known to be resistant to Leishmania major infection. We here found t...

journal_title：Biochemical and biophysical research communications

authors： Morimoto N,Murata Y,Motegi S,Suzue K,Saito Y,Okazawa H,Ohnishi H,Kotani T,Kusakari S,Ishikawa O,Matozaki T

更新日期：2010-10-22 00:00:00

abstract：:The interaction of calcyclin with tropomyosin and tropomyosin-actin was studied with fluorescence titrations and photo-reactive crosslinking experiments. Titrations of pyreneiodoacetamide-labeled tropomyosin alone or with actin showed binding of calcyclin to tropomyosin with muM dissociation constants when Ca2+ was pr...

journal_title：Biochemical and biophysical research communications

authors： Golitsina NL,Kordowska J,Wang CL,Lehrer SS

更新日期：1996-03-18 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma, co-activator 1 alpha(PGC1α) effectively induced the biosynthesis of the mitochondria and the energy metabolism, and also regulated the muscle fiber-type shift. Overexpression of PGC1α gene in mice led to higher oxidative muscle fiber composition in muscle. However,...

journal_title：Biochemical and biophysical research communications

authors： Ying F,Zhang L,Bu G,Xiong Y,Zuo B

更新日期：2016-11-25 00:00:00