Expression analysis and chromosomal assignment of PRA1 and RILP genes.

abstract：:In rats, administration of a single dose of cysteamine (300 mg/kg, intragastrically) induces a depletion of pancreatic somatostatin content (approximately 60%) without modifying pancreatic insulin or glucagon content. In perfused pancreases from cysteamine-treated rats, there was a lack of somatostatin response to glu...

journal_title：Biochemical and biophysical research communications

authors： Silvestre RA,Miralles P,Moreno P,Villanueva ML,Marco J

更新日期：1986-02-13 00:00:00

abstract：:We describe a new approach to DNA hybridization assays using metal-enhanced fluorescence. Thiolated oligonucleotides were bound to silver particles on a glass substrate. Addition of a complementary fluorescein-labeled oligonucleotide resulted in a dramatic time-dependent 12-fold increase in fluorescence intensity duri...

journal_title：Biochemical and biophysical research communications

authors： Malicka J,Gryczynski I,Lakowicz JR

更新日期：2003-06-20 00:00:00

abstract：:A cDNA containing the entire coding sequence for the subunit protein of rat liver class theta glutathione S-transferase (GST) Yrs-Yrs was isolated from a rat liver lambda gt11 cDNA library. The cDNA, designated GST theta-1, consisted of 1,258 bp which had an open reading frame of 732 bp encoding a polypeptide of 244 a...

journal_title：Biochemical and biophysical research communications

authors： Ogura K,Nishiyama T,Okada T,Kajital J,Narihata H,Watabe T,Hiratsuka A,Watabe T

更新日期：1991-12-31 00:00:00

abstract：:Despite the fact that the phosphorylation-mediated regulation of L-type Ca channels is viewed as a model of ion channel regulation, much remains to be learned about the protein phosphorylation and dephosphorylation reactions that underlie the regulation of the channels. The channel isoform most well studied biochemica...

journal_title：Biochemical and biophysical research communications

authors： Zhao XL,Gutierrez LM,Chang CF,Hosey MM

更新日期：1994-01-14 00:00:00

abstract：:Listeria monocytogenes is a Gram-positive intracellular bacterium that was transmitted through contaminated food and causes sepsis and even death. IL-37 has been described as an important anti-inflammatory factor, but little is known about the function of IL-37 in host defense against Liseria monocytogenes (Lm) infect...

journal_title：Biochemical and biophysical research communications

authors： Zhao M,Hu Y,Shou J,Su SB,Yang J,Yang T

更新日期：2017-04-01 00:00:00

abstract：:Previous studies in our laboratory have shown that specific glycan structures are required for the normal secretion of some glycoproteins. Bromoconduritol is known to inhibit the removal of the innermost glucose moiety from the Glc3Man9(GlcNAc)2 precursor of N-linked glycoproteins. We have used this inhibitor to inves...

journal_title：Biochemical and biophysical research communications

authors： Yeo KT,Yeo TK,Olden K

更新日期：1989-06-30 00:00:00

abstract：:Metyrapone, an inhibitor of cytochrome P-450-dependent monooxygenases, enhanced the induction of tyrosine aminotransferase by dexamethasone in primary cultures of hepatocytes, while it had no effect on the basal level of the enzyme activity in the absence of the hormone. The amplification of the hormonal induction of ...

journal_title：Biochemical and biophysical research communications

authors： Tongiani R,Piazzolla S,Paolicchi A

更新日期：1990-01-30 00:00:00

abstract：:Activity of thalamic neurons has been shown to be modulated via type-1 metabotropic glutamate receptor (mGluR1) activation, which initiates an intracellular Ca signaling cascade involving phospholipase Cbeta4 (PLCbeta4) and leading to the activation of conventional protein kinase C (cPKC). In the present study, we inv...

journal_title：Biochemical and biophysical research communications

authors： Kameyama M,Yamaguchi I,Ichikawa K,Sugiyama T,Hirono M,Hori H,Ikeda M,Kuwahata Y,Eguchi N,Urade Y,Yoshioka T

更新日期：2003-04-25 00:00:00

abstract：:Two novel subtilisin-like serine proteases (AS-E1 and -E2) that activate prothrombin have been identified in a culture of the fungus Acremonium sp. The enzymes were purified through repeated hydrophobic interaction chromatography. The N-terminal sequences of AS-E1 (34.4 kDa) and AS-E2 (32 kDa) showed high similarity t...

journal_title：Biochemical and biophysical research communications

authors： Liu C,Matsushita Y,Shimizu K,Makimura K,Hasumi K

更新日期：2007-06-22 00:00:00

abstract：:The extracellular microenvironment plays a key role in regulation of cellular functions and growth control. We show here that membrane-type 1 matrix metalloproteinase (MT1-MMP) acts as a growth promoter in confluent culture. When MT1-MMP was silenced in HT1080 fibrosarcoma cells, cells created three dimensional (3D) f...

journal_title：Biochemical and biophysical research communications

authors： Takino T,Guo L,Domoto T,Sato H

更新日期：2013-07-05 00:00:00

abstract：:Hemangioma is a benign tumor derived from abnormal blood vessel growth. Unlike other vascular tumor counterparts, a hemangioma is known to proliferate during its early stage but it is followed by a stage of involution where regression of the tumor occurs. The critical onset leading to the involution of hemangioma is c...

journal_title：Biochemical and biophysical research communications

authors： Kim KJ,Yun JH,Heo JI,Lee EH,Min HS,Choi TH,Cho CH

更新日期：2014-11-14 00:00:00

abstract：:A Golgi enriched fraction from rat brain was prepared. The preparation has no carboxypeptidase activity and is not contaminated with cytosol, mitochondria and lysosomes as judged by marker enzyme activities for these constituents. Associated with the Golgi membranes a putative opioid peptide processing activity was de...

journal_title：Biochemical and biophysical research communications

authors： Demmer W,Brand K

更新日期：1986-07-16 00:00:00

abstract：:Store-operated Ca(2+) entry (SOCE) is crucial for various physiological responses in immune cells. Although it is known that STIM1 relocates into discrete puncta juxtaposed to the plasma membrane to initiate SOCE, the machinery modulating the function of STIM1 remains unclear. We explored to find its modulators using ...

journal_title：Biochemical and biophysical research communications

authors： Fujii Y,Shiota M,Ohkawa Y,Baba A,Wanibuchi H,Kinashi T,Kurosaki T,Baba Y

更新日期：2012-06-15 00:00:00

abstract：:Dysregulation of autophagy has been observed in obesity and type 2 diabetes. Salt-inducible kinase 2 (SIK2), a member of the AMPK-related kinase family, is downregulated in adipocytes from obese or insulin resistant individuals and was previously demonstrated to regulate autophagy in cancer and normal cell lines. The ...

journal_title：Biochemical and biophysical research communications

authors： Negoita F,Säll J,Morén B,Stenkula K,Göransson O

更新日期：2019-01-15 00:00:00

abstract：:The effects of cyclosporin A (CSP) on tumor necrosis factor-alpha (TNF-alpha) RNA levels and protein production in human B cells and a B cell line were studied. The ability of CSP to block induction of RNA was compared to its inhibition of protein production in response to anti-IgM, phorbol ester (PMA) and platelet-ac...

journal_title：Biochemical and biophysical research communications

authors： Smith CS,Ortega G,Parker L,Shearer WT

更新日期：1994-10-14 00:00:00

abstract：:The process in which nucleotide is buried into the active site of heavy meromyosin was studied with stopped-flow apparatus by monitoring the time-course of the large fluorescence increase of 1,N6-ethenoadenosine triphosphate (epsilon-ATP) when it binds from acrylamide-containing solutions. We have recently reported th...

journal_title：Biochemical and biophysical research communications

authors： Ando T,Duke JA

更新日期：1983-08-30 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) had been proved to be pivotal regulators in carcinogenesis. On the basis of competitive endogenous RNAs (ceRNAs) system, lncRNAs significantly expanded their regulating networks. In our research, we aimed to figure out the exact role of lncRNA HNF1A-AS1 in the pathogenesis of hepatocellu...

journal_title：Biochemical and biophysical research communications

authors： Liu Z,Wei X,Zhang A,Li C,Bai J,Dong J

更新日期：2016-05-13 00:00:00

abstract：:Bacillus thuringiensis var. israelensis produces 130 kDa delta-endotoxin which is highly toxic to mosquito-larvae. The mosquito-larvicidal activity was delineated by sequential deletions from ends of the 1136 amino acids delta-endotoxin. A maximum of 459 amino acids could be removed from the carboxy-terminal of the to...

journal_title：Biochemical and biophysical research communications

authors： Pao-intara M,Angsuthanasombat C,Panyim S

更新日期：1988-05-31 00:00:00

abstract：:Antibodies subjected to SDS-polyacrylamide gel electrophoresis and transferred to nitrocellulose paper, have been found to retain the ability to bind specific antigen. This has been demonstrated for two groups of antibodies, directed to a) a large molecular weight glycoprotein of the human milk fat globule and b) huma...

journal_title：Biochemical and biophysical research communications

authors： Mather S,Taylor-Papadimitriou J

更新日期：1985-12-31 00:00:00

abstract：:The activity of Cav1.2 Ca(2+) channels is maintained in the presence of calmodulin and ATP, even in cell-free patches, and thus a channel ATP-binding site has been suggested. In this study, we examined whether other nucleotides, such as GTP, UTP, CTP, ADP and AMP, could be substituted for ATP in guinea-pig ventricular...

journal_title：Biochemical and biophysical research communications

authors： Liu SY,Xu JJ,Minobe E,Gao QH,Feng R,Zhao MM,Guo F,Yang L,Hao LY,Kameyama M

更新日期：2015-05-08 00:00:00

abstract：:Glucose-dependent insulinotropic polypeptide is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. The glucose-dependent action of GIP on pancreatic beta-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. Use of NMR or X-ray...

journal_title：Biochemical and biophysical research communications

authors： Alaña I,Hewage CM,Malthouse JP,Parker JC,Gault VA,O'Harte FP

更新日期：2004-12-03 00:00:00

abstract：:A complementary DNA library prepared from the 12S polyadenylated RNAs extracted from interferon-induced KG-1 cells, a human myeloblast cell line, was screened for the presence of induction-specific sequences. Clones that exhibited strong positive signals were separated by hybridization criteria into nine classes. Clon...

journal_title：Biochemical and biophysical research communications

authors： Tsuzuki T,Nomiyama H,Setoyama C,Maeda S,Shimada K,Pestka S

更新日期：1983-07-29 00:00:00

abstract：:In hair follicle cells APCDD1 inhibits the canonical WNT/β-Catenin pathway and its inactivation is associated with an autosomal dominant form of hair loss. We analyzed the role of APCDD1 for the osteogenic differentiation in dental follicle cells (DFCs) and identified a new and surprising function. Contrarily to hair ...

journal_title：Biochemical and biophysical research communications

authors： Viale-Bouroncle S,Klingelhöffer C,Ettl T,Morsczeck C

更新日期：2015-02-13 00:00:00

abstract：:A common cause for pharmacogenetic alteration in drug response is genetic variation in encoded amino acid sequence. We have used the catecholamine and drug-metabolizing enzyme sulfotransferase (SULT)1A3 to create an artificial model system to study mechanisms-especially possible aggresome formation-by which genetic al...

journal_title：Biochemical and biophysical research communications

authors： Wang L,Yee VC,Weinshilboum RM

更新日期：2004-12-10 00:00:00

abstract：:The Sir proteins, namely Sir2, 3 and 4, have roles related to heterochromatin, but genome-wide studies have revealed their presence at many euchromatic loci, although the functional meaning of this is still not clear. Nhp6a is an abundant HMG-like protein in yeast, which has a role in transcription by modulating chrom...

journal_title：Biochemical and biophysical research communications

authors： Ciuffetta A,Salerno D,Camilloni G,Venditti S

更新日期：2015-05-22 00:00:00

abstract：:To gain further insight into the biochemical properties of the antibacterial hexetidine, isolated rat liver mitochondria were added with this drug and investigation made of certain features related to mitochondrial bioenergetics. Hexetidine was found to cause oxidation of intramitochondrial pyridine nucleotides and st...

journal_title：Biochemical and biophysical research communications

authors： D'Arcangelo G,Barile M,Passarella S,Quagliariello E

更新日期：1987-09-15 00:00:00

abstract：:Pentoxyresorufin O-depentylase activity, mainly associated with phenobarbital-inducible cytochrome P450IIB1 (designated CYP2B1), was increased after a single treatment of pyridine (250 mg/kg, i.p.), and further increased by repeated treatments for 5 days. The catalytic activity and immunoreactive protein of CYP2B reco...

journal_title：Biochemical and biophysical research communications

authors： Park KS,Sohn DH,Veech RL,Song BJ

更新日期：1992-06-15 00:00:00

abstract：:The cDNAs for two casein kinase-1 homologs, hhp1 and hhp2, have been isolated from Schizosaccharomyces pombe and characterized. Their corresponding genes reside on chromosomes II and I, respectively, and encode approximately 42-46 kDa proteins that are related structurally to the HRR25 gene product of budding yeast. O...

journal_title：Biochemical and biophysical research communications

authors： Kearney PH,Ebert M,Kuret J

更新日期：1994-08-30 00:00:00

abstract：:Two types of natriuretic peptide, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), very similar to each other in structure and in pharmacological effect, are known to be present in mammalian heart and brain. In our present survey for unidentified peptides in porcine brain extracts, we found a new ...

journal_title：Biochemical and biophysical research communications

authors： Sudoh T,Minamino N,Kangawa K,Matsuo H

更新日期：1990-04-30 00:00:00

abstract：:Apolipoprotein (apo-) B mRNA editing at nucleotide 6666 converts cytidine to uridine, transforming the codon for glutamine-2153 to a termination codon. To investigate this editing mechanism, [a-32P] and [5-3H] CTP were incorporated into synthetic apo-B RNA. After the substrate had been edited extensively in vitro by a...

journal_title：Biochemical and biophysical research communications

authors： Johnson DF,Poksay KS,Innerarity TL

更新日期：1993-09-30 00:00:00