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β-elemene inhibits tumor-promoting effect of M2 macrophages in lung cancer.

Abstract：

:Macrophages in tumor are mostly M2-polarized and have been reported to promote tumorigenesis, which are also defined as tumor-associated macrophages (TAMs). β-elemene has therapeutic effects against several cancers, however, it remains unknown whether β-elemene could inhibit cancer by targeting TAMs. Herein, we examined the effect of β-elemene on macrophages to elucidate a novel mechanism of β-elemene in tumor therapy. We showed that the conditioned medium of M2 macrophages promoted lung cancer cells to migration, invasion and epithelial mesenchymal transition, which could be inhibited by β-elemene. Moreover, β-elemene regulated the polarization of macrophages from M2 to M1. β-elemene also inhibited the proliferation, migration, invasion of lung cancer cells and enhanced its radiosensitivity. These results indicate β-elemene suppresses lung cancer by regulating both macrophages and lung cancer cells, it is a promising drug for combination with chemotherapy or radiotherapy.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yu X,Xu M,Li N,Li Z,Li H,Shao S,Zou K,Zou L

doi

10.1016/j.bbrc.2017.06.071

subject

Has Abstract

pub_date

2017-08-19 00:00:00

pages

514-520

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)31203-2

journal_volume

490

pub_type

杂志文章

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