Abstract:
:Receptor tyrosine kinase EphA7 is specifically expressed in otic region in Xenopus early development. However, its role in otocyst development remains unknown. Knockdown of EphA7 by a specific morpholino oligonucleotide (MO) reduced the size of the otocyst and triggered otic epithelial cell extrusion. Interestingly, EphA7 depletion attenuated the membrane level of the tight junction protein Claudin6 (CLDN6). Utilizing the Cldn6 MO, we further confirmed that CLDN6 attenuation also led to otic epithelial cell extrusion. Our work suggested that EphA7 modulates the otic epithelial homeostasis through stabilizing the CLDN6 membrane level.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Wang X,Sun J,Wang Z,Li C,Mao Bdoi
10.1016/j.bbrc.2020.03.099subject
Has Abstractpub_date
2020-05-28 00:00:00pages
375-380issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(20)30590-8journal_volume
526pub_type
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