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Prostaglandin E1 and prostaglandin I2 modulation of superoxide production by human neutrophils.

Abstract：

:15(S)-15-methyl-prostaglandin E1 and prostaglandin I2 rapidly and reversibly inhibit formyl-methionyl-leucyl-phenylalanine induced superoxide production by human neutrophils. In contrast, 15(S)-15-methyl-prostaglandin E1 and prostaglandin I2 did not alter the rate or the total amount of superoxide production by human neutrophils stimulated with either phorbol myristate acetate or arachidonic acid. These data suggest that the production of superoxide anion by human neutrophils may be mediated by at least two mechanisms, one regulated by prostaglandins and intracellular cyclic adenosine monophosphate levels and a second independent of prostaglandin modulation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Fantone JC,Kinnes DA

doi

10.1016/0006-291x(83)91754-0

subject

Has Abstract

pub_date

1983-06-15 00:00:00

pages

506-12

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(83)91754-0

journal_volume

113

pub_type

杂志文章

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