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AKT-p53 axis protect cancer cells from autophagic cell death during nutrition deprivation.

Abstract：

:An altered metabolism supports growth of tumor. AKT, a major signal integrator plays a key role in cell metabolism. We have shown that nutritional deprivation activates AKT as observed by increased phosphorylation of both Thr308 and Ser473. Pharmacological inhibition or silencing of AKT by siRNA affects cell viability during starvation. The tumor suppressor, p53 is also observed to be elevated during nutritional deprivation due to AKT. Silencing of AKT and p53 enhanced autophagy as evidenced by increased acidic vesicular organelles and LC3B II levels, suggesting AKT-p53 to play a significant role in cell survival through regulating autophagy during nutritional deprivation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sudhagar S,Sathya S,Gokulapriya G,Lakshmi BS

doi

10.1016/j.bbrc.2016.02.064

subject

Has Abstract

pub_date

2016-03-18 00:00:00

pages

396-401

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(16)30253-4

journal_volume

471

pub_type

杂志文章

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