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Synergism of vitamins A and C on fibrinolysis.

Abstract：

:A hitherto unknown synergism exerted by retinol (vitamin A) and L-ascorbic acid (vitamin C) was discovered using endothelial cells. Retinol stimulated the extracellular and intracellular activities of plasminogen activator up to approximately 8- and 4-fold from the control values, respectively. L-Ascorbic acid enhanced the extracellular and intracellular activities up to approximately 1.5-fold. Above all it was demonstrated that their effects on extracellular activity were synergistic; simultaneous administration of these two vitamins enhanced the extracellular activity up to a 20- to 50-fold. Synthesis of plasminogen activator induced with vitamins A and C was inhibited by a protein synthesis inhibitor, cycloheximide.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Inada Y,Hagiwara H,Kojima S,Shimonaka M,Saito Y

doi

10.1016/0006-291x(85)90399-7

subject

Has Abstract

pub_date

1985-07-16 00:00:00

pages

182-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)90399-7

journal_volume

130

pub_type

杂志文章

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