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Impaired growth of pancreatic exocrine cells in transgenic mice expressing human activin betaE subunit.

Abstract：

:Activins, TGF-beta superfamily members, have multiple functions in a variety of cells and tissues. Recently, additional activin beta subunit genes, betaC and betaE, have been identified. To explore the role of activin E, we created transgenic mice overexpressing human activin betaE subunit. There were pronounced differences in the pancreata of the transgenic animals as compared with their wild-type counterparts. Pancreatic weight, expressed relative to total body weight, was significantly reduced. Histologically, adipose replacement of acini in the exocrine pancreas was observed. There was a significant decrease in the number of PCNA-positive cells in the acinar cells, indicating reduced proliferation in the exocrine pancreas of the transgenic mice. However, quantitative pancreatic morphometry showed that the total number and mass of the islets of the transgenic mice were comparable with those of the nontransgenic control mice. Our findings suggest a role for activin E in regulating the proliferation of pancreatic exocrine cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hashimoto O,Ushiro Y,Sekiyama K,Yamaguchi O,Yoshioka K,Mutoh K,Hasegawa Y

doi

10.1016/j.bbrc.2005.12.205

subject

Has Abstract

pub_date

2006-03-10 00:00:00

pages

416-24

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)00043-X

journal_volume

341

pub_type

杂志文章

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