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Establishment of a novel method for enriching osteoblast progenitors from adipose tissues using a difference in cell adhesive properties.

Abstract：

:In the clinical field, cell-based therapies are used to treat bone defects. Adipose tissues contain many osteoblast progenitors, among other cell types. We separated mouse adipose tissue-derived stromal cells (ATSCs) according to their cell adhesive properties. Cells in a fraction adherent to the culture dishes 0.5h after inoculation (AF-0.5) had a potent ability to differentiate into both osteoblasts and adipocytes in vitro. Their differentiation pathways depended on the culture conditions. In these cells, the expression of marker genes for osteoblast differentiation was induced in osteogenic medium. Moreover, the AF-0.5 cells, which were induced to differentiate into osteoblasts in vitro, formed abundant bone tissues in vivo. These results suggest that the AF-0.5 cells have been enriched with bi-potential progenitor cells destined for either osteoblasts or adipocytes. This simple and efficient method for preparing osteoblast progenitor cells from ATSCs may be utilized for bone defect treatment clinically.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hattori H,Ishihara M,Fukuda T,Suda T,Katagiri T

doi

10.1016/j.bbrc.2006.03.061

subject

Has Abstract

pub_date

2006-05-19 00:00:00

pages

1118-23

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)00576-6

journal_volume

343

pub_type

杂志文章

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