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Involvement of tetrahydrobiopterin in trophic effect of erythropoietin on PC12 cells.

Abstract：

:Tetrahydrobiopterin (BH(4)) synthesis is reported to be stimulated by nerve growth factor (NGF) in PC12 cells, suggesting involvement of BH(4) in the trophic effect of NGF. We have recently reported that erythropoietin (EPO) and BH(4) enhance survival of PC12 cells. In the present study, we investigated involvement of BH(4) in the trophic effect of EPO on PC12 cells. Cellular BH(4) content was increased by EPO (10(-10) to 10(-8) M) in a dose- and time-related manner. EPO (10(-10) to 10(-8) M) increased the viable cell number of PC12 cells. In addition to EPO, BH(4) (1, 3, and 10 microM) increased the viable cell number of PC12 cells. Administration of 0.3 mM 2,4-diamino-6-hydroxypyrimidine, an inhibitor of BH(4) synthesis, blunted EPO-induced increases in BH(4) content and the viable cell number of PC12 cells. These results taken together suggest that BH(4) is involved in the trophic effects of EPO on PC12 cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tanaka J,Koshimura K,Sohmiya M,Murakami Y,Kato Y

doi

10.1006/bbrc.2001.6002

subject

Has Abstract

pub_date

2001-11-30 00:00:00

pages

358-62

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(01)96002-4

journal_volume

289

pub_type

杂志文章

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