Sonic hedgehog expression during early tooth development in Suncus murinus.

Abstract:

:Tooth development is a highly organized process characterized by reciprocal interactions between epithelium and mesenchyme. However, the expression patterns and functions of molecules involved in mouse tooth development are unclear from the viewpoint of explaining human dental malformations and anomalies. Here, we show the expression of sonic hedgehog (Shh), a potent initiator of morphogenesis, during the early stages of tooth development in Suncus murinus. Initially, symmetrical, elongated expression of suncus Shh (sShh) was observed in the thin layer of dental epithelial cells along the mesial-distal axis of both jaws. As the dental epithelium continued to develop, sShh was strictly restricted to the predicted leading parts of the growing, invaginating epithelium corresponding to tooth primordia and enamel knots. We propose that some aspects of Shh function in tooth development are widely conserved in mammalian phylogeny.

authors

Miyado M,Ogi H,Yamada G,Kitoh J,Jogahara T,Oda S,Sato I,Miyado K,Sunohara M

doi

10.1016/j.bbrc.2007.08.158

subject

Has Abstract

pub_date

2007-11-16 00:00:00

pages

269-75

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01791-3

journal_volume

363

pub_type

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