Abstract:
:Tooth development is a highly organized process characterized by reciprocal interactions between epithelium and mesenchyme. However, the expression patterns and functions of molecules involved in mouse tooth development are unclear from the viewpoint of explaining human dental malformations and anomalies. Here, we show the expression of sonic hedgehog (Shh), a potent initiator of morphogenesis, during the early stages of tooth development in Suncus murinus. Initially, symmetrical, elongated expression of suncus Shh (sShh) was observed in the thin layer of dental epithelial cells along the mesial-distal axis of both jaws. As the dental epithelium continued to develop, sShh was strictly restricted to the predicted leading parts of the growing, invaginating epithelium corresponding to tooth primordia and enamel knots. We propose that some aspects of Shh function in tooth development are widely conserved in mammalian phylogeny.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Miyado M,Ogi H,Yamada G,Kitoh J,Jogahara T,Oda S,Sato I,Miyado K,Sunohara Mdoi
10.1016/j.bbrc.2007.08.158subject
Has Abstractpub_date
2007-11-16 00:00:00pages
269-75issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(07)01791-3journal_volume
363pub_type
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