Inhibitory effect of 11-carbonyl-beta-boswellic acid on non-small cell lung cancer H446 cells.

abstract：:Previous genetic evidence led to the conclusion that proteinase B of yeast was not involved in the function of chitin synthetase 1 (Chs1), based on the demonstration of normal septum formation, cell division and chitin deposition in mutants devoid of the proteinase (Zubenko, G.S., Mitchell, A.P., and Jones, E.W. (1979...

journal_title：Biochemical and biophysical research communications

authors： Silverman SJ,Shaw JA,Cabib E

更新日期：1991-01-15 00:00:00

abstract：:Human bone marrow cells express both a truncated and full-length form of the erythropoietin receptor (EpoR-T and EpoR-F, respectively). Transfection experiments using the murine interleukin (IL)-3-dependent cell line, Ba/F3, revealed that the cells coexpressing EpoR-F and EpoR-T (Ba/F3-FT) were more likely to undergo ...

journal_title：Biochemical and biophysical research communications

authors： Shimizu R,Komatsu N,Nakamura Y,Nakauchi H,Nakabeppu Y,Miura Y

更新日期：1996-05-06 00:00:00

abstract：:Lipopolysaccharides (LPS) induces intrahepatic cholestasis and canalicular multispecific organic anion transporter (CMOAT/MRP2) plays a central role in hepatic bilirubin transport. This study examined the role of Kupffer cell in LPS-induced cholestasis. Rats were injected intravenously with LPS. Kupffer cells were ina...

journal_title：Biochemical and biophysical research communications

authors： Nakamura J,Nishida T,Hayashi K,Kawada N,Ueshima S,Sugiyama Y,Ito T,Sobue K,Matsuda H

更新日期：1999-02-05 00:00:00

abstract：:Treatment of rats with phenobarbital for three days greatly increases the activity of 2,5 oligoadenylate synthetase in liver nuclei. Analysis of 2',5'-oligoadenylates synthesized in vitro showed that nuclei from both phenobarbital-treated and control rats synthesized 2',5'-oligoadenylates ranging from di- to hexamers....

journal_title：Biochemical and biophysical research communications

authors： Liu DK,Owens GF

更新日期：1984-06-29 00:00:00

abstract：:The effect of the mitochondrial dye rhodamine 123 (Rho 123) on protein synthesis (PS) activity was investigated in mitochondria isolated from liver and from both chloroma and erythroleukemia tumors. Incorporation of labelled leucine into mitochondrial protein was used to measure the rate of PS. While PS specific activ...

journal_title：Biochemical and biophysical research communications

authors： Abou-Khalil WH,Arimura GK,Yunis AA,Abou-Khalil S

更新日期：1986-06-13 00:00:00

abstract：:One of the mechanisms underlying the induction of human inducible nitric oxide synthase (hiNOS) by cytokines is transcriptional regulation. However, previous reports suggest that in human cells, the cytokine activation of the hiNOS expression is accompanied by a drastic increase in cellular mRNA and protein content, b...

journal_title：Biochemical and biophysical research communications

authors： Nunokawa Y,Oikawa S,Tanaka S

更新日期：1997-04-17 00:00:00

abstract：:The Fragile X protein FMRP is an RNA binding protein whose targets are not well known; yet, these RNAs may play an integral role in the disease's etiology. Using a biotinylated-FMRP affinity resin, we isolated RNAs from the parietal cortex of a normal adult that bound FMRP. These RNAs were amplified by differential di...

journal_title：Biochemical and biophysical research communications

authors： Sung YJ,Conti J,Currie JR,Brown WT,Denman RB

更新日期：2000-09-07 00:00:00

abstract：:Bone mass is controlled by a balance between bone resorption and formation by osteoclasts and osteoblasts, respectively. An imbalance between osteoblasts and osteoclasts increases the risk of osteoporosis and fractures. Although inhibition of osteoclasts is beneficial for preventing and treating osteoporosis, enhanced...

journal_title：Biochemical and biophysical research communications

authors： Bae SJ,Min YK,Hwang ES

更新日期：2017-05-27 00:00:00

abstract：:GV1001, a synthetic peptide derived from human telomerase, has a range of diverse biological activities, including an antioxidant function. Here, we investigated the role of GV1001 in hepatitis C virus (HCV)-infected Huh7.5 (JFH-1) cells. We showed that GV1001 inhibited the production of ROS with decreased MAP kinase ...

journal_title：Biochemical and biophysical research communications

authors： Lee SA,Kim J,Sim J,Kim SG,Kook YH,Park CG,Kim HR,Kim BJ

更新日期：2016-02-26 00:00:00

abstract：:The effect of steroid chemical structure on steroid-lipid interaction is studied in sonicated dipalmitoyl phosphatidylcholine vesicles by steady-state and time-resolved fluorescence anisotropy techniques using diphenylhexatriene as probe. A large number of cholesterol derivatives and steroids, some of them being precu...

journal_title：Biochemical and biophysical research communications

authors： Vincent M,Gallay J

更新日期：1983-06-29 00:00:00

abstract：:Nischarin, a novel integrin binding protein, has been demonstrated its negative effects on cell migration and invasion. However, the biological role of Nischarin in breast cancer has not been fully elucidated yet. Our study aimed to analyze the association between Nischarin expression and clinical features of breast c...

journal_title：Biochemical and biophysical research communications

authors： Chang C,Wei W,Han D,Meng J,Zhu F,Xiao Y,Wu G,Shi X,Zhang L

更新日期：2017-03-11 00:00:00

abstract：:Receptor binding properties of the hemoglobin-derived nonapeptide VV-hemorphin 7 (Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe-OH) were studied using both the unlabelled form and tritium-labelled derivative of the peptide. In binding studies using selective opioid radioligands, VV-hemorphin 7 exhibited a rank order of potency ...

journal_title：Biochemical and biophysical research communications

authors： Szikra J,Benyhe S,Orosz G,Darula Z,Piot JM,Fruitier I,Monory K,Hanoune J,Borsodi A

更新日期：2001-03-02 00:00:00

abstract：:The human pancreas carcinoma cell line T3M-4 contains activated c-Kirsten (K)-ras oncogene detectable by the DNA-mediated gene transfer technique using NIH/3T3 cells. DNA fragments containing coding lesions have been cloned, and nucleotide sequence analysis suggests that the T3M-4 oncogene has been activated by a sing...

journal_title：Biochemical and biophysical research communications

authors： Hirai H,Okabe T,Anraku Y,Fujisawa M,Urabe A,Takaku F

更新日期：1985-02-28 00:00:00

abstract：:A novel aptameric enzyme subunit (AES) which can detect target DNAs has been developed. AES is an enzyme-inhibiting aptamer bearing a target-molecule binding site which can allosterically control enzymatic activity. The thrombin-inhibiting aptamer bearing a G-quartet structure was chosen as the enzyme-inhibiting aptam...

journal_title：Biochemical and biophysical research communications

authors： Yoshida W,Sode K,Ikebukuro K

更新日期：2006-09-15 00:00:00

abstract：:Immunoblot analysis of the conditioned medium of v-Ha-ras-transformed NIH3T3 cells showed that Ras protein is secreted in the culture fluid. Because cathepsins L and B whose activities are inhibited by Ras are also secreted, possible association between Ras and cathepsins was investigated by immunoprecipitation and fo...

journal_title：Biochemical and biophysical research communications

authors： Hiwasa T,Kominami E

更新日期：1995-11-22 00:00:00

abstract：:Receptor tyrosine kinase EphA7 is specifically expressed in otic region in Xenopus early development. However, its role in otocyst development remains unknown. Knockdown of EphA7 by a specific morpholino oligonucleotide (MO) reduced the size of the otocyst and triggered otic epithelial cell extrusion. Interestingly, E...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Sun J,Wang Z,Li C,Mao B

更新日期：2020-05-28 00:00:00

abstract：:Germ-line alterations in BRCA1 are associated with an increased susceptibility to breast and ovarian cancer. The BRCA1 protein has been implicated in multiple cellular functions. We have recently demonstrated that BRCA1 reduces acetyl-CoA-carboxylase alpha (ACCA) activity through its phospho-dependent binding to ACCA,...

journal_title：Biochemical and biophysical research communications

authors： Ray H,Suau F,Vincent A,Dalla Venezia N

更新日期：2009-01-16 00:00:00

abstract：:Snake venom metalloproteinases (SVMPs) are key toxins involved in local inflammatory reactions after snakebites. This study aimed to investigate the effect of SVMP domains on the alterations in leukocyte-endothelium interactions in the microcirculation of mouse cremaster muscle. We studied three toxins: BnP1, a PI-tox...

journal_title：Biochemical and biophysical research communications

authors： Zychar BC,Clissa PB,Carvalho E,Baldo C,Gonçalves LRC

更新日期：2020-01-08 00:00:00

abstract：:A rabbit liver P-450-like pseudogene has been isolated from a lambda phage genomic library. Sequence analysis revealed structural homology with respect to the rat P-450b and P-450e genes as well as a similar intron-exon organization. A 5'-proximal TATA box-like sequence and two 3'-distal putative polyadenylation signa...

journal_title：Biochemical and biophysical research communications

authors： Zaphiropoulos PG,Folk WR,Coon MJ

更新日期：1986-01-29 00:00:00

abstract：:Aggregation of the high-affinity IgE receptor (FcepsilonRI) activates a tyrosine phosphorylation cascade needed for enhanced adhesion and degranulation events on mast cells. We previously identified the adaptor ADAP (otherwise known as FYB/SLAP) as a modulator of integrin-mediated adhesion of T-cells and mast cells. H...

journal_title：Biochemical and biophysical research communications

authors： Geng L,Rudd C

更新日期：2001-12-21 00:00:00

abstract：:The newly identified drug transporter MRP is functionally linked to a multiple drug resistance independent from P-glycoprotein. Resistance modifiers for this type of MDR are rare at present. We analyzed the modulating effect of the highly selective bisindolylmaleimide PKC inhibitor GF 109203X on the MRP overexpressing...

journal_title：Biochemical and biophysical research communications

authors： Gekeler V,Boer R,Ise W,Sanders KH,Schächtele C,Beck J

更新日期：1995-01-05 00:00:00

abstract：:Trilobolide and 2,5-di(tert-butyl)-1,4-benzohydroquinone (BHQ) are potent inhibitors of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum. Desoxytrilobolide and 2,5-di(tert-butyl)-1,4-diacetylphenol (acetyl-BHQ) have much lower potencies than their parent compounds and 2,5-di(tert-butyl)-1,4-benzoquinone (BQ...

journal_title：Biochemical and biophysical research communications

authors： Wictome M,Holub M,East JM,Lee AG

更新日期：1994-03-15 00:00:00

abstract：:We attempted to attenuate neointimal formation following vascular injury using a retroviral suicide vector. Epicardial coronary arteries of adult miniature swine were injured by deployment of oversized tantalum stents. One week later, injured segments were exposed to packaged retroviral constructs with or without the ...

journal_title：Biochemical and biophysical research communications

authors： Barbee RW,Stapleton DD,Madras DE,Ré RN,Murgo JP,Davenport WD,Giardina J,Cook JL

更新日期：1995-02-06 00:00:00

abstract：:Prostate cancer has become one of commonest urologic tumors in male. In recent years, miRNAs are continually attracting attentions of researchers for their special regulatory function in human cancers. Previous study has revealed that miR-410 acts as a biomarker for the diagnosis of prostate cancer. Whereas, the speci...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Zhang D,Lv J,Wang S,Zhang Q

更新日期：2018-09-18 00:00:00

abstract：:Pigment epithelium-derived factor (PEDF) encoded by serpinf1 is a potent antiangiogenic factor found in a wide variety of fetal and adult tissues. Several reports have shown that lack of PEDF leads to osteogenesis imperfecta (OI) type VI whose hallmark is a defect in mineralization that leads to excessive osteoid buil...

journal_title：Biochemical and biophysical research communications

authors： Li F,Armstrong GB,Tombran-Tink J,Niyibizi C

更新日期：2016-09-23 00:00:00

abstract：:A great challenge for gene therapy is to develop a high efficient gene delivery system with low toxicity. Nonviral vectors are still attractive although the current agents displayed some disadvantages (i.e., low transfection efficiency, high toxicity). To overcome the high toxicity of poly(ethylene imine) (PEI) and lo...

journal_title：Biochemical and biophysical research communications

authors： Liang B,He ML,Xiao ZP,Li Y,Chan CY,Kung HF,Shuai XT,Peng Y

更新日期：2008-03-21 00:00:00

abstract：:Aqueous extracts of cigarette tar produce hydroxyl radicals that are spin trapped by 5,5-dimethyl-1-pyrroline-N-oxide. The addition of catalase almost completely inhibits and superoxide dismutase partially inhibits spin adduct formation. The addition of ethylenediamine tetraacetic acid greatly increases the amount of ...

journal_title：Biochemical and biophysical research communications

authors： Cosgrove JP,Borish ET,Church DF,Pryor WA

更新日期：1985-10-15 00:00:00

abstract：:Human hepatocarcinoma Hep G2 cells were grown in culture medium containing [45Ca2+]. The secreted lipoproteins of d less than 1.063 g/ml and d 1.063-1.21 g/ml were isolated from the culture media and analyzed by 3.3% and 7% SDS-polyacrylamide gel electrophoresis. Radioactivity profiles of [45Ca] from the gels showed t...

journal_title：Biochemical and biophysical research communications

authors： Dashti N,Lee DM,Mok T

更新日期：1986-05-29 00:00:00

abstract：:Cell motility and cell stiffness are closely related to metastatic activity of cancer cells. (-)-Epigallocatechin gallate (EGCG) has been shown to inhibit spontaneous metastasis of melanoma cell line into the lungs of mice, so we studied the effects of EGCG on cell motility, cell stiffness, and expression of vimentin ...

journal_title：Biochemical and biophysical research communications

authors： Takahashi A,Watanabe T,Mondal A,Suzuki K,Kurusu-Kanno M,Li Z,Yamazaki T,Fujiki H,Suganuma M

更新日期：2014-01-03 00:00:00

abstract：:Two proteins (25- and 22-kDa) that cross-react with anti-gizzard SM22 alpha antibody were isolated from bovine aorta. The former, identical to a SM22 alpha homolog reported previously (Kobayashi, R., Kubota, T., and Hidaka, H. (1994) Biochem. Biophys. Res. Commun. 198, 1275-1280), associates with the membrane fraction...

journal_title：Biochemical and biophysical research communications

authors： Shishibori T,Yamashita K,Bandoh J,Oyama Y,Kobayashi R

更新日期：1996-12-04 00:00:00