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Differential regulation of dynein-driven melanosome movement.

Abstract：

:Cytoplasmic dyneins are multisubunit minus-end-directed microtubule motors. Different isoforms of dynein are thought to provide a means for independent movement of different organelles. We investigated the differential regulation of dynein-driven transport of pigment organelles (melanosomes) in Xenopus melanophores. Aggregation of melanosomes to the cell center does not change the localization of mitochondria, nor does dispersion of melanosomes cause a change in the perinuclear localization of the Golgi complex, indicating that melanosomes bear a dedicated form of dynein. We examined the subcellular fractionation behavior of dynein light intermediate chains (LIC) and identified at least three forms immunologically, only one of which fractionated with melanosomes. Melanosome aggregation was specifically blocked after injection of an antibody recognizing this LIC. Our data indicate that melanosome-associated dynein is regulated independently of bulk cytoplasmic dynein and involves a subfraction of dynein with a distinct subunit composition.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Reilein AR,Serpinskaya AS,Karcher RL,Dujardin DL,Vallee RB,Gelfand VI

doi

10.1016/j.bbrc.2003.08.047

subject

Has Abstract

pub_date

2003-09-26 00:00:00

pages

652-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X03016371

journal_volume

309

pub_type

杂志文章

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