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Cardiomyocyte lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs.

Abstract：

:Here we sought to evaluate the effect of palmitate on cytokine and PPAR activity/expression. We investigated the effect of BSA conjugated palmitate and oleate on PPAR activity, PPAR-α and δ expression, as well as the expression of cytokines and key factors responsible for β-oxidation by qRT-PCR and western blotting in primary rat neonatal cardiomyocytes (NCMs). Furthermore we evaluated the effect of anti-inflammatory actions of AICAR and PPAR agonists on cytokine expression and cell death in palmitate treated NCMs. We found that palmitate caused down regulation of PPARs and increased cytokine expression and cell death, all of which was significantly attenuated by the co-administration of either AICAR or PPAR agonists. This work supports the pro-inflammatory actions of intracellular lipid and provides further insight into the pathological mechanism of cardiac lipotoxicity as occurs in diabetic hearts.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Haffar T,Bérubé-Simard FA,Bousette N

doi

10.1016/j.bbrc.2015.02.062

subject

Has Abstract

pub_date

2015-03-27 00:00:00

pages

54-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)00290-9

journal_volume

459

pub_type

杂志文章

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