COBRA1 inhibits AP-1 transcriptional activity in transfected cells.

abstract：:Nitric oxide causes apoptotic cell death in RAW 264.7 macrophages. The cellular response to the NO donor S-nitrosoglutathione (GSNO) comprises an apoptotic morphology and DNA fragmentation, which largely depends on the accumulation of the tumor suppressor gene product p53. Pre-treatment of macrophages with LPS, IFN-ga...

journal_title：Biochemical and biophysical research communications

authors： Brüne B,Gölkel C,von Knethen A

更新日期：1996-12-13 00:00:00

abstract：:We cloned two novel types of TEA domain-containing transcription factor (ETFR-1 and -2) cDNAs. Amino acid sequences deduced for ETFR-1 and -2 as well as those of other known proteins of the same family, TEF-1 and ETF, exhibited significant identity (63-75% overall) to each other not only in the TEA DNA binding domain ...

journal_title：Biochemical and biophysical research communications

authors： Yasunami M,Suzuki K,Ohkubo H

更新日期：1996-11-12 00:00:00

abstract：:The clinical effects of serpin polymerisation include thromboembolism, emphysema, and liver disease. A through understanding of serpin polymerisation mechanisms and the structures involved will permit the rational design of therapeutic polymerisation inhibitors. Here we show that serpin polymerisation can be delayed b...

journal_title：Biochemical and biophysical research communications

authors： Bottomley SP,Chang WS

更新日期：1997-12-18 00:00:00

abstract：:An apparently novel human plasma and urinary protein of low molecular weight was isolated from several highly purified preparations of protein HC by gel chromatography and high voltage electrophoresis with a yield of about 8 mg/g. The protein has a molecular weight of about 20,000, neutral electrophoretic mobility at ...

journal_title：Biochemical and biophysical research communications

authors： López-Otin C,Grubb AO,Méndez E

更新日期：1983-11-30 00:00:00

abstract：:Lipopolysaccharides (LPS) of Porphyromonas gingivalis have been implicated in the initiation and development of periodontal diseases. In a previous study, we investigated the signal transduction pathway of P. gingivalis and demonstrated that LPS stimulates the production of interleukin (IL)-6 in human gingival fibrobl...

journal_title：Biochemical and biophysical research communications

authors： Wang PL,Shirasu S,Shinohar M,Azuma Y,Daito M,Yasuda H,Ohura K

更新日期：1999-09-24 00:00:00

abstract：:A synthetic peptide corresponding to the seven carboxy-terminal amino acids of tyrosine aminotransferase was coupled to ovalbumin or keyhole limpet haemocyanin, and the resulting conjugates were used to raise anti-peptide antibodies by immunization of rabbits. The crude sera were purified and tested for recognition of...

journal_title：Biochemical and biophysical research communications

authors： Dietrich JB,Genot G,Beck G

更新日期：1987-04-29 00:00:00

abstract：:Destruxin B, a peptide antibiotic, inhibits vacuolar-type ATPase (V-ATPase) specifically and dose-dependently among ATPases examined. Acidification of intracellular organelles is also blocked by destruxin B at comparable concentrations when assessed by accumulation of acridine orange. The inhibitory activity of destru...

journal_title：Biochemical and biophysical research communications

authors： Muroi M,Shiragami N,Takatsuki A

更新日期：1994-12-15 00:00:00

abstract：:RT-PCR, a rapidly emerging technique for the detection of RNA, is being used by many investigators to quantify small amounts of RNA. Accurate quantification of RNA content has been facilitated by the use of competitive amplicons as internal controls. We demonstrate that losses in sensitivity and accuracy are associate...

journal_title：Biochemical and biophysical research communications

authors： Henley WN,Schuebel KE,Nielsen DA

更新日期：1996-09-04 00:00:00

abstract：:As in other vitamin D target cells, activation of voltage-dependent Ca2+ channels (VDCC) mediates the fast, non-genomic, 1,25(OH)2D3 stimulation of Ca2+ influx in skeletal muscle cells (SMC). 1,25(OH)2D3 has also been shown to rapidly induce the release of Ins(1,4,5)P3 in SMC. Experiments were performed to investigate...

journal_title：Biochemical and biophysical research communications

authors： Vazquez G,de Boland AR,Boland R

更新日期：1997-10-20 00:00:00

abstract：:The distribution of somatostatin immunoreactive forms in three tissues of the anglerfish (Lophius piscatorius L.) was analyzed by a combination of gel permeation, High Pressure Liquid Chromatography and amino acid analysis. The data indicate that prosomatostatins I and II are expressed in both neural and gastro-intest...

journal_title：Biochemical and biophysical research communications

authors： Morel A,Kuks PF,Bourdais J,Cohen P

更新日期：1988-02-29 00:00:00

abstract：:In growing neurite of neuronal cells, it is suggested that α/β-tubulin heterodimers assemble to form microtubule, and assembly of microtubule promotes neurite elongation. On the other hand, recent studies reveal importance of intracellular Cl(-) in regulation of various cellular functions such as cell cycle progressio...

journal_title：Biochemical and biophysical research communications

authors： Nakajima K,Niisato N,Marunaka Y

更新日期：2012-08-24 00:00:00

abstract：:Low voltage-activated, rapidly inactivating T-type Ca(2+) channels are found in a variety of cells where they regulate electrical activity and Ca(2+) entry. In whole-cell patch clamp recordings from bovine adrenal zona fasciculata cells, cis-polyunsaturated omega-3 fatty acids including docosahexaenoic acid (DHA), eic...

journal_title：Biochemical and biophysical research communications

authors： Danthi SJ,Enyeart JA,Enyeart JJ

更新日期：2005-02-11 00:00:00

abstract：:Autophagy is an evolutionary conserved intracellular process whereby cells break down long-lived proteins and organelles. Accumulating evidences suggest increasing physiological significance of autophagy in pathogenesis of infectious diseases. Anthrax lethal toxin (LT) exerts its influence on numerous cells and herein...

journal_title：Biochemical and biophysical research communications

authors： Tan YK,Kusuma CM,St John LJ,Vu HA,Alibek K,Wu A

更新日期：2009-02-06 00:00:00

abstract：:Diphenyleneiodonium (DPI) and N-acetyl-l-cysteine (NAC), two widely used anti-oxidants, were employed to evaluate the role of oxidative stress in Japanese encephalitis virus (JEV) induced autophagy, stress responses and replication. DPI and NAC exerted opposite effects on ROS levels in JEV infected mouse neuronal cell...

journal_title：Biochemical and biophysical research communications

authors： Sharma M,Sharma KB,Chauhan S,Bhattacharyya S,Vrati S,Kalia M

更新日期：2018-07-12 00:00:00

abstract：:It was previously shown that rhodanese, inactivated with hydrogen peroxide, could only be reactivated in the presence of a reductant or the substrate thiosulfate if these reagents were added soon after inactivation and if the oxidant was removed. Here, we report on the facilitated reactivation (75%) of hydrogen peroxi...

journal_title：Biochemical and biophysical research communications

authors： Del Fierro D,Zardeneta G,Mendoza JA

更新日期：2000-08-02 00:00:00

abstract：:Branched-chain alpha-keto acid dehydrogenase (BCKDH) kinase (BDK) is responsible for the regulation of BCKDH complex, which is the rate-limiting enzyme in the catabolism of branched-chain amino acids (BCAAs). In the present study, we investigated the expression and activity of hepatic BDK in spontaneous type 2 diabete...

journal_title：Biochemical and biophysical research communications

authors： Doisaki M,Katano Y,Nakano I,Hirooka Y,Itoh A,Ishigami M,Hayashi K,Goto H,Fujita Y,Kadota Y,Kitaura Y,Bajotto G,Kazama S,Tamura T,Tamura N,Feng GG,Ishikawa N,Shimomura Y

更新日期：2010-03-05 00:00:00

abstract：:Start domain-containing protein 3 (Stard3) plays roles in intracellular cholesterol distribution, however, the role of Stard3 in the adipogenesis of 3T3-L1 preadipocytes remains unclear. We demonstrated that Stard3 expression was significantly increased during the adipogenesis of 3T3-L1 preadipocytes, accompanied by a...

journal_title：Biochemical and biophysical research communications

authors： Zhou X,Gao H,Guo Y,Chen Y,Ruan XZ

更新日期：2018-10-02 00:00:00

abstract：:Hammerhead ribozymes may be of great therapeutic importance, since they can, in theory, be developed to cleave any undesired target RNA. In order to design ribozymes which are stable against endogenous RNases, we incorporated 2'-acetamido-2'-deoxynucleosides in the catalytic core of a hammerhead ribozyme. The 2'-aceta...

journal_title：Biochemical and biophysical research communications

authors： Hendrix C,Mahieu M,Anné J,Van Calenbergh S,Van Aerschot A,Content J,Herdewijn P

更新日期：1995-05-05 00:00:00

abstract：:The endoplasmic reticulum (ER) is an organelle in which most membrane and secretory proteins are synthesized. If these proteins are not folded correctly, unfolded proteins accumulate in the ER lumen, causing a cellular situation known as ER stress. Recently, many studies on the relationship between ER stress and disea...

journal_title：Biochemical and biophysical research communications

authors： Hosoda A,Maruyama A,Oikawa D,Oshima Y,Komachi Y,Kanai G,Sato H,Iwawaki T

更新日期：2011-02-04 00:00:00

abstract：:We have cloned the cDNA encoding human PICK1 (protein interacting with C kinase 1), a PDZ domain-containing protein of 415 amino acids, and also identified the Drosophila homologue by search of the databank. Northern blot analysis shows a single mRNA of about 2.0 kb ubiquitously expressed in human tissues. Although PI...

journal_title：Biochemical and biophysical research communications

authors： Takeya R,Takeshige K,Sumimoto H

更新日期：2000-01-07 00:00:00

abstract：:Although most somatic cells cannot proliferate, immature cells proliferate continuously to produce mature cells. Recently, we cloned mouse PSF1 from a hematopoietic stem cell specific cDNA library and reported that PSF1 is indispensable for the proliferation of immature cells. To identify the PSF1-binding protein, we ...

journal_title：Biochemical and biophysical research communications

authors： Kong L,Ueno M,Itoh M,Yoshioka K,Takakura N

更新日期：2006-01-27 00:00:00

abstract：:The synthetic-peptide strategy was used to generate antibodies raised against calcium-dependent lectins of vertebrates. We demonstrate that a synthetic peptide predicted from the amino acid sequence of the carbohydrate recognition domain can induce blocking antibodies which would react with, or in close vicinity of, t...

journal_title：Biochemical and biophysical research communications

authors： Blanck O,Thibault V,Granier C,Van Rietschoten J,Courageot J,Miquelis R

更新日期：1990-06-29 00:00:00

abstract：:Neuroblastoma LAN-5 cells exposed to retinoic acid cease to multiply and extend neurite outgrowths acquiring a neuronal phenotype. We now report that protein kinase C-theta; (PKC-theta;) isozyme is involved in this differentiation process due to the following findings: (i) PKC-theta; is expressed by LAN-5 cells as a n...

journal_title：Biochemical and biophysical research communications

authors： Sparatore B,Patrone M,Passalacqua M,Pedrazzi M,Pontremoli S,Melloni E

更新日期：2000-12-20 00:00:00

abstract：:The role of inducible nitric oxide synthase (iNOS) in the progression of fibrosis during nonalcoholic steatohepatitis remains to be elucidated. This study examined the role of iNOS in the progression of fibrosis during steatohepatitis by comparing iNOS knockout (iNOS(-/-)) and wild-type (iNOS(+/+)) mice that were fed ...

journal_title：Biochemical and biophysical research communications

authors： Chen Y,Hozawa S,Sawamura S,Sato S,Fukuyama N,Tsuji C,Mine T,Okada Y,Tanino R,Ogushi Y,Nakazawa H

更新日期：2005-01-07 00:00:00

abstract：:Runt-related transcription factor 2 (Runx2), also known as core binding factor 1 (Cbfa1), is a multifunctional transcription factor and an essential master gene controlling osteoblast differentiation. We previously demonstrated the in vivo functions of Runx2 in mesoderm-derived cells. However, no studies have been con...

journal_title：Biochemical and biophysical research communications

authors： Shirai Y,Kawabe K,Tosa I,Tsukamoto S,Yamada D,Takarada T

更新日期：2019-02-19 00:00:00

abstract：:Ornithine decarboxylase (ODC), which catalyzes polyamine biosynthesis, plays an essential role in cell growth. DL-alpha-Difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, inhibits cell growth. However, the exact mechanism by which polyamine depletion by DFMO results in growth inhibition remains to be elucid...

journal_title：Biochemical and biophysical research communications

authors： Nemoto T,Kamei S,Seyama Y,Kubota S

更新日期：2001-01-26 00:00:00

abstract：:Sodium dodecyl sulfate (SDS), a representative anionic surfactant, is a commonly used reagent in studies of the cell membrane and cell wall. However, the mechanisms through which SDS affects cellular functions have not yet been fully examined. Thus, to gain further insights into the cellular functions and responses to...

journal_title：Biochemical and biophysical research communications

authors： Zhao F,Yang J,Li J,Li Z,Lin Y,Zheng S,Liang S,Han S

更新日期：2020-06-18 00:00:00

abstract：:The molecular mechanism of the phosphorylation-dependent activation of tryptophan hydroxylase is studied with respect to the role of the 14-3-3 protein. Reexamination of the system reconstituted with the purified TRH and the 14-3-3 protein showed that the level of the TRH activity correlated with the extent of the Ca2...

journal_title：Biochemical and biophysical research communications

authors： Furukawa Y,Ikuta N,Omata S,Yamauchi T,Isobe T,Ichimura T

更新日期：1993-07-15 00:00:00

abstract：:The translation terminator Sup35p assembles into self-replicating fibrillar aggregates that are responsible for the [PSI+] prion state. The Q/N-rich N-terminal domain together with the highly charged middle-domain (NM domain) drive the assembly of Sup35p into amyloid fibrils in vitro. NM domains are highly divergent a...

journal_title：Biochemical and biophysical research communications

authors： Kabani M,Melki R

更新日期：2020-08-27 00:00:00

abstract：:A human cell line established from a patient of an acute monocytic leukemia (THP-1) retained an ability to synthesize and secrete plasma apolipoprotein E like protein. The protein was identified with monospecific antibody raised against human plasma apolipoprotein E. The cells also secreted lipoprotein lipase (EC 3.1....

journal_title：Biochemical and biophysical research communications

authors： Tajima S,Hayashi R,Tsuchiya S,Miyake Y,Yamamoto A

更新日期：1985-01-16 00:00:00