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A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns.

Abstract：

:We cloned two novel types of TEA domain-containing transcription factor (ETFR-1 and -2) cDNAs. Amino acid sequences deduced for ETFR-1 and -2 as well as those of other known proteins of the same family, TEF-1 and ETF, exhibited significant identity (63-75% overall) to each other not only in the TEA DNA binding domain but also in the C-terminal regions. Northern blot analysis revealed that both the mRNAs were expressed in embryos as well as in many adult tissues, although their levels of expression varied. The results demonstrate that the mammalian TEA domain-containing transcription factor family consists of at least four distinct members, TEF-1, ETF, ETFR-1, and ETFR-2, which exhibit overlapping but differing spatiotemporal expression patterns, suggesting their redundant yet unique roles involved in not only developmental control but also tissue-specific regulation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yasunami M,Suzuki K,Ohkubo H

doi

10.1006/bbrc.1996.1667

subject

Has Abstract

pub_date

1996-11-12 00:00:00

pages

365-70

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)91667-8

journal_volume

228

pub_type

杂志文章

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