Regulation of human hepatocyte gene expression by fatty acids.

Abstract:

:It is known that fatty acids (FAs) regulate transcription through a number of FA responsive transcription factors. In order to investigate the effect of FAs on gene regulation in cultured human hepatocytes we examined the effect of palmitate on hepatic glucokinase (GK) promoter activity and expression of transcription factors that regulate GK expression. GK promoter activity was increased in constructs lacking a cAMP response element (CRE), while palmitate incubation decreased GK promoter activity in CRE-negative constructs. Cells exposed to palmitate showed increased levels of PPARalpha apolipoprotein-AII and -B100 mRNA and decreased levels of SREBP-1c mRNA but there was no effect on LXRalpha and HNF-4alpha mRNA. In addition, cDNA microarray analysis of short-term (1.5h) transcriptional regulation by palmitate, oleate, and eicosapentaenoic acid (EPA) identified that oleate and EPA initiated similar changes in the pattern of hepatic gene regulation, whereas palmitate had little effect.

authors

Swagell CD,Henly DC,Morris CP

doi

10.1016/j.bbrc.2007.07.191

subject

Has Abstract

pub_date

2007-10-19 00:00:00

pages

374-80

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01672-5

journal_volume

362

pub_type

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