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Structure of prejunctional receptor binding analog of human neuropeptide Y dimer ANA-NPY.

Abstract：

:Human neuropeptide Y (NPY) analog ANA-NPY or [L17, Q19, A20, A23, L28, L31]NPY (13-36)-amide binds weakly to postjunctional receptors to raise blood pressure but binds tightly to prejunctional receptors to inhibit neurotransmitter release. ANA-NPY forms a well-conserved anti-parallel helical structure overlapping E23-Y36 with strong amphipathic character. The C-terminal portions of the monomers are better defined than the N-terminal ends. The N-terminal helices extend only from D16-E23/L24. The prejunctional receptor-specific binding site is confined within the C-terminal helices while the residues responsible for partial binding to the postjunctional receptors are located in the more disordered N-terminal segments.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Barden JA

doi

10.1006/bbrc.1995.2461

subject

Has Abstract

pub_date

1995-10-04 00:00:00

pages

264-71

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)72461-8

journal_volume

215

pub_type

杂志文章

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