Rat kidney microsomes convert 25-hydroxyvitamin D3 to an unidentified metabolite.

Abstract:

:Kidney microsomes from vitamin D-deficient rats and from thyroparathyroidectomized rats converted 25-hydroxyvitamin D3 to an unidentified metabolite. The addition of the cytosolic fraction enhanced microsomal synthesis of this metabolite two-fold. The kinetics of the conversion in the presence of the cytosolic fraction was allosteric, suggesting that the enzyme responsible for synthesis of this metabolite might serve some role in the regulation of vitamin D metabolism. Microsomes from vitamin D-fed thyroparathyroidectomized rats also produced a second metabolite, tentatively identified as 25,26-dihydroxyvitamin D3 because of its comigration with 25,26-dihydroxyvitamin D3 in three different chromatographic systems.

authors

Thierry-Palmer M,Gray TK,Williams ME,Talmage RV

doi

10.1016/0006-291x(83)91027-6

subject

Has Abstract

pub_date

1983-02-10 00:00:00

pages

766-71

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(83)91027-6

journal_volume

110

pub_type

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