Abstract:
:Kidney microsomes from vitamin D-deficient rats and from thyroparathyroidectomized rats converted 25-hydroxyvitamin D3 to an unidentified metabolite. The addition of the cytosolic fraction enhanced microsomal synthesis of this metabolite two-fold. The kinetics of the conversion in the presence of the cytosolic fraction was allosteric, suggesting that the enzyme responsible for synthesis of this metabolite might serve some role in the regulation of vitamin D metabolism. Microsomes from vitamin D-fed thyroparathyroidectomized rats also produced a second metabolite, tentatively identified as 25,26-dihydroxyvitamin D3 because of its comigration with 25,26-dihydroxyvitamin D3 in three different chromatographic systems.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Thierry-Palmer M,Gray TK,Williams ME,Talmage RVdoi
10.1016/0006-291x(83)91027-6subject
Has Abstractpub_date
1983-02-10 00:00:00pages
766-71issue
3eissn
0006-291Xissn
1090-2104pii
0006-291X(83)91027-6journal_volume
110pub_type
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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