Involvement of hepatocyte growth factor in formation of bronchoalveolar structures in embryonic rat lung in primary culture.

Abstract:

:To clarify the role of hepatocyte growth factor (HGF) in embryonic lung development, organoids from fetal rat lung were cultured in collagen gels with or without HGF antisense oligonucleotides. Cyst-like structures formed within 24 h in organoids isolated from fetuses after 14 days' gestation, but this was abolished by the oligonucleotide addition, apparently by interference with the endogenous expression of HGF. Electron microscopy revealed two types of structure: an alveolar type characterized by osmiophilic lamellar bodies in the cytoplasm and lumen, and a bronchial type consisting of epithelial cells bearing microvilli on their apical surfaces. HGF mRNA was detectable from day 14 in fetal lung by RT-PCR. Our results suggest that HGF plays, coordinately with its expression, a crucial role in the morphogenesis of both alveolar and bronchial epithelia in the rat fetal lung.

authors

Itakura A,Kurauchi O,Morikawa S,Okamura M,Furugori K,Mizutani S

doi

10.1006/bbrc.1997.7526

subject

Has Abstract

pub_date

1997-12-08 00:00:00

pages

98-103

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)97526-4

journal_volume

241

pub_type

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