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Inflammatory effect of endosulfan via NF-kappaB activation in macrophages.

Abstract：

:Macrophages are essential for the inflammatory response process because they release a wide variety of proinflammatory mediators. Endosulfan is extremely toxic to invertebrates and has been implicated in various mammalian toxicities. However, its influence on production of cytokine or on the functions of macrophages is unclear. This study examined the effects of endosulfan on the production of nitric oxide (NO) and proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha), and examined the molecular mechanism in macrophages. Exposing macrophages to endosulfan induced the production of NO and proinflammatory cytokines and the expression of these genes. The transient transfection and electrophoretic mobility shift assays with the NF-kappaB binding sites showed that the NF-kappaB transcription factor mediated the endosulfan-induced increase in the expression levels of iNOS and proinflammatory cytokines. These results show that endosulfan stimulates the production of NO and proinflammatory cytokines and can up-regulate the gene expression levels through NF-kappaB transactivation. Overall, these results suggest that endosulfan has inflammatory potential.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Han EH,Hwang YP,Kim HG,Jeong HG

doi

10.1016/j.bbrc.2007.01.062

subject

Has Abstract

pub_date

2007-04-20 00:00:00

pages

860-5

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)00108-8

journal_volume

355

pub_type

杂志文章

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