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Expression pattern of acidic and basic fibroblast growth factor genes in adult rat eyes.

Abstract：

:Although the retinal angiogenic and mitogenic factors have been identified to be acidic and basic fibroblast growth factors (aFGF and bFGF), little information has so far been available about the cells producing them and their function in retinal tissues. We found, by in situ hybridization, that the expression pattern of the aFGF gene differed remarkably from that of the bFGF gene in adult rat eyes. Our results demonstrated that the aFGF gene was produced by photoreceptor visual cells, neuronal cells in the inner nuclear layer and ganglion cells of the retina, in addition to pigment epithelial cells of the choroid, iris and ciliary body, and epithelial cells of the cornea, conjunctiva and lens, while bFGF was synthesized solely by the photoreceptor visual cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Noji S,Matsuo T,Koyama E,Yamaai T,Nohno T,Matsuo N,Taniguchi S

doi

10.1016/0006-291x(90)91714-4

subject

Has Abstract

pub_date

1990-04-16 00:00:00

pages

343-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)91714-4

journal_volume

168

pub_type

杂志文章

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