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DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras.

Abstract：

:We have isolated and characterized the cDNA encoding a novel protein designated DJ-1. DJ-1, sharing no significant homology with the sequences so far reported, did not show transactivation activity in the Gal4 recombinant system, but transformed mouse NIH3T3 cells by itself. Furthermore, DJ-1 showed a cooperative transforming activity with H-Ras, more than 3 times as strong as the activity of ras/myc combination. DJ-1 was ubiquitously expressed in various human tissues, and the expression was induced by growth stimuli. Moreover, DJ-1 translocated from cytoplasm to nuclei in the S phase of the cell cycle. DJ-1 is thus suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nagakubo D,Taira T,Kitaura H,Ikeda M,Tamai K,Iguchi-Ariga SM,Ariga H

doi

10.1006/bbrc.1997.6132

subject

Has Abstract

pub_date

1997-02-13 00:00:00

pages

509-13

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)96132-5

journal_volume

231

pub_type

杂志文章

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