Tyk2 mediates effects of urokinase on human vascular smooth muscle cell growth.

abstract：:Evidence exists that the adenosine receptor A(2A)R and the dopamine receptor D(2)R form constitutive heteromers in living cells. Mass spectrometry and pull-down data showed that an arginine-rich domain of the D(2)R third intracellular loop binds via electrostatic interactions to a specific motif of the A(2A)R C-termin...

journal_title：Biochemical and biophysical research communications

authors： Borroto-Escuela DO,Marcellino D,Narvaez M,Flajolet M,Heintz N,Agnati L,Ciruela F,Fuxe K

更新日期：2010-03-26 00:00:00

abstract：:Transcriptional factors (TFs) are key regulators in orchestrating gene transcription during cancer development. However, their roles in glioma remain elusive. Here, we analyzed the differential expression of TFs and identified ZNF436 is upregulated in glioblastoma and Lower Grade Glioma patients. High expression of ZN...

journal_title：Biochemical and biophysical research communications

authors： Shang Y,Li Y,Zhang Y,Wang J

更新日期：2019-08-06 00:00:00

abstract：:Transgenic mouse which produces human alpha-fetoprotein (AFP) ubiquitously was used to study carbohydrate structures of AFP produced by various tissues as well as that in the serum. A series of tissues from the transgenic mouse were cultured in vitro and the AFP produced was analyzed by affinity electrophoreses with 4...

journal_title：Biochemical and biophysical research communications

authors： Koyama Y,Sakai M,Kitagawa T,Taketa K,Nishi S

更新日期：1996-06-25 00:00:00

abstract：:Hydrogen peroxide, tert-butyl hydroperoxide, cumene hydroperoxide, and 3-chloroperoxybenzoic acid (CPB) and 15-HPETE relaxed, in a concentration dependent manner rat aortic rings contracted with PGF2 alpha (1 X 10(-5)). Relaxation is not inhibited by either indomethacin (2 X 10(-5) M), a cyclo-oxygenase inhibitor or e...

journal_title：Biochemical and biophysical research communications

authors： Thomas G,Ramwell P

更新日期：1986-08-29 00:00:00

abstract：:Although cancer patients initially respond well to chemotherapy, they eventually develop resistance and relapse. In this work, we demonstrate that eIF4E-targeting therapy is a potential sensitizing strategy for overcoming chemoresistance and progression in cancer. We show that ribavirin, an anti-viral drug and pharmac...

journal_title：Biochemical and biophysical research communications

authors： Xi C,Wang L,Yu J,Ye H,Cao L,Gong Z

更新日期：2018-09-18 00:00:00

abstract：:Complete nucleotide sequence of the genes for subunits of the H+ ATPase of E.coli has been determined and several hybrid plasmids carrying various portions of these genes have been constructed. Genetic complementation and recombination tests of about forty mutants of E.coli defective in the ATPase were performed using...

journal_title：Biochemical and biophysical research communications

authors： Noumi T,Kanazawa H

更新日期：1983-02-28 00:00:00

abstract：:We isolated genomic DNA containing the entire sequence of ZF5, which was originally identified by its ability to repress the mouse c-myc promoter and which was characterized as one of the POZ (Poxvirus and zinc finger) proteins. The POZ motif is a protein-protein interaction interface found at the N-terminal region of...

journal_title：Biochemical and biophysical research communications

authors： Yokoro K,Yanagidani A,Obata T,Yamamoto S,Numoto M

更新日期：1998-05-29 00:00:00

abstract：:This study describes the purification and characterization of an aminopeptidase from human cerebrospinal fluid capable of degrading delta-sleep-inducing-peptide (DSIP). The enzyme has an apparent molecular weight of approximately 80,000 dalton. It is sensitive towards amastatin, bestatin and EDTA and is optimally acti...

journal_title：Biochemical and biophysical research communications

authors： Nyberg F,Thörnwall M,Hetta J

更新日期：1990-03-30 00:00:00

abstract：:MicroRNA-125a exhibits an antiproliferative activity and is downregulated in several types of tumors, including hepatocellular carcinoma where it targets sirtuin-7, matrix metalloproteinase-11, and c-Raf. Another target of miR-125a is Lin28, a pluripotency factor that is generally undetectable in differentiated cells ...

journal_title：Biochemical and biophysical research communications

authors： Panella M,Mosca N,Di Palo A,Potenza N,Russo A

更新日期：2018-06-07 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Xiao F,Hu Q,Zeng M,Guan L,Liu X,Yang Y,Zhong C

更新日期：2012-04-13 00:00:00

abstract：:The crystal structure of the NTF2-like domain of the Drosophila homolog of Ras GTPase SH3 Binding Protein (G3BP), Rasputin, was determined at 2.7Å resolution. The overall structure is highly similar to nuclear transport factor 2: It is a homodimer comprised of a β-sheet and three α-helices forming a cone-like shape. H...

journal_title：Biochemical and biophysical research communications

authors： Vognsen T,Kristensen O

更新日期：2012-03-30 00:00:00

abstract：:Exposure of rat atrial slices to 10(-5) M norepinephrine (NE) for 10 minutes increases 45Ca++ accumulation from 1.64 +/- 0.10 to 2.23 +/- 0.06 nmol/mg tissue. In the presence of leucine enkephalin (10(-8) M), NE-stimulated 45Ca++ uptake is reduced to 1.44 +/- 0.10 nmol/mg tissue. The effect of leu-enkephalin is revers...

journal_title：Biochemical and biophysical research communications

authors： Ruth JA,Cuizon JV,Eiden LE

更新日期：1983-12-16 00:00:00

abstract：:By alignment to the carboxy-terminal-deduced aa sequence of human cytomegalovirus glycoprotein B (gB), conserved hexameric aa motifs with putative function for localization in the inner nuclear membrane (INM) were identified in the nucleoplasmic tails of herpes simplex virus type 1 gB and of the cellular lamin B recep...

journal_title：Biochemical and biophysical research communications

authors： Meyer G,Gicklhorn D,Strive T,Radsak K,Eickmann M

更新日期：2002-03-08 00:00:00

abstract：:The cell surface receptor integrin is involved in signaling mechanical stresses via the focal adhesion complex (FAC) into the cell. Within FAC, the focal adhesion kinase (FAK) and Pyk2 are believed to act as important scaffolding proteins. Based on the knowledge that many signal transducing molecules are transiently i...

journal_title：Biochemical and biophysical research communications

authors： Klemm AH,Kienle S,Rheinlaender J,Schäffer TE,Goldmann WH

更新日期：2010-03-19 00:00:00

abstract：:Low temperatures cause cellular damage in flower buds of the sweet cherry (Prunus avium L. cv. Satohnishiki). In this study, the redox states within the cherry buds suffering freezing damage were non-destructively observed by a unique in vivo electron spin resonance (ESR) technique with a spin probe such as carbamoyl-...

journal_title：Biochemical and biophysical research communications

authors： Tada M,Shiraishi T,Takashina T,Ohya H,Ogata T

更新日期：2003-10-10 00:00:00

abstract：:To examine the possibility that inter-individual differences in splicing partially explain the observed differences in CYP2D6 activity, we amplified its full-length cDNA in 96 human liver RNA samples and discovered five splice variants: intron 5 retention, intron 6 retention, intron 5 and intron 6 double retention, ex...

journal_title：Biochemical and biophysical research communications

authors： Denson J,Wu Y,Yang W,Zhang J

更新日期：2005-05-06 00:00:00

abstract：:MDMX is a homolog of MDM2 and is critical for regulating p53 function during mouse development. MDMX level is regulated by MDM2-mediated poly-ubiquitination, which results in its accelerated degradation after DNA damage or expression of ARF. In this report, we demonstrate that MDMX can be modified by conjugation to SU...

journal_title：Biochemical and biophysical research communications

authors： Pan Y,Chen J

更新日期：2005-07-08 00:00:00

abstract：:Septic shock induced by lipopolysaccharide (LPS) is characterized by serious systemic inflammatory response and robust production of pro-inflammatory cytokines from activated macrophages. Damage-associated molecular patterns (DAMPs) secreted by activated macrophages are key contributors to septic shock. However, the c...

journal_title：Biochemical and biophysical research communications

authors： He Y,Peng Y,Tao L,Peng Z,Yang H

更新日期：2020-07-05 00:00:00

abstract：:Dual effect of dibromothymoquinone ( DBMIB ), inhibitor and reducing agent at the donor side of Photosystem I, was investigated in isolated intact chloroplasts by flash-induced absorbance changes at 820 and 515 nm. We show that in the absence of other electron donors, rereduction of P700+ by DBMIB proceeds at a very l...

journal_title：Biochemical and biophysical research communications

authors： Farineau J,Bottin H,Garab G

更新日期：1984-05-16 00:00:00

abstract：:Coordinated migration of endothelial cells models the remodeling of existing endothelia as well as angiogenesis and vasculogenesis. Platelet-endothelial cell adhesion molecule-1, PECAM-1, a transmembrane endothelial adhesion protein, binds and activates the tyrosine phosphatase SHP-2 via phosphotyrosines 663 and 686. ...

journal_title：Biochemical and biophysical research communications

authors： Gratzinger D,Barreuther M,Madri JA

更新日期：2003-01-31 00:00:00

abstract：:Centromere protein F (CENPF) is an essential nuclear protein associated with the centromere-kinetochore complex and plays a critical role in chromosome segregation during mitosis. Up-regulation of CENPF expression has previously been detected in several solid tumors. In this study, we aim to study the expression and f...

journal_title：Biochemical and biophysical research communications

authors： Dai Y,Liu L,Zeng T,Zhu YH,Li J,Chen L,Li Y,Yuan YF,Ma S,Guan XY

更新日期：2013-07-12 00:00:00

abstract：:Plexin-B1 regulates various cellular processes interacting directly with several Rho proteins. Molecular details of these interactions are, however, not well understood. In this study, we examined in vitro and in silico the interaction of the Rho binding domain (B1RBD) of human Plexin-B1 with 11 different Rho proteins...

journal_title：Biochemical and biophysical research communications

authors： Fansa EK,Dvorsky R,Zhang SC,Fiegen D,Ahmadian MR

更新日期：2013-05-17 00:00:00

abstract：:Hippocampus is one of the most vulnerable tissues to glucocorticoid (GC). In the present study, we demonstrate that dexamethasone (DEX), a synthetic GC, induces apoptotic cell death in hippocampal progenitor HiB5 cells without any additional insult. Interestingly, expression of 27-kDa heat shock protein (HSP27) was ma...

journal_title：Biochemical and biophysical research communications

authors： Son GH,Geum D,Chung S,Park E,Lee KH,Choi S,Kim K

更新日期：2005-12-30 00:00:00

abstract：:Ceramide kinase (CERK) produces the bioactive lipid ceramide 1-phosphate (C1P) and is, together with glucosylceramide synthase (GCS) and sphingomyelin synthases (SMS-1 and -2), a key regulator of ceramide metabolism. Here, we used a previously validated assay for measuring CERK, GCS, and SMS activities simultaneously,...

journal_title：Biochemical and biophysical research communications

authors： Rovina P,Graf C,Bornancin F

更新日期：2010-08-20 00:00:00

abstract：:Fission yeast cell division is initiated by the cdc2/cdc13-cyclin protein kinase which in its catalytically active state comprises the mitotic inducer. During interphase the cdc2/cyclin complex is assembled in an inactive state that requires cdc25+ gene function for M-phase activation. The cdc25+ product, a 76 kd phos...

journal_title：Biochemical and biophysical research communications

authors： Ducommun B,Draetta G,Young P,Beach D

更新日期：1990-02-28 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that catalyzes the synthesis of ADP-ribose polymers from NAD(+). The function of PARP-1 is related to important nuclear processes including DNA repair and transcription. Previous studies demonstrated a specific physical interaction between PARP-1 and the trans...

journal_title：Biochemical and biophysical research communications

authors： Oei SL,Shi Y

更新日期：2001-06-08 00:00:00

abstract：:We have compared the sequence and gene order of meta-cleavage pathway operons from alpha- and gamma-subgroups of the Proteobacteria with operons from Burkholderia sp. strain RP007 which belongs to the beta-subgroup of the Proteobacteria. Burkholderia RP007 was isolated for its ability to degrade phenanthrene and conta...

journal_title：Biochemical and biophysical research communications

authors： Laurie AD,Lloyd-Jones G

更新日期：1999-08-19 00:00:00

abstract：:To investigate the mechanism underlying the antiatherogenic effect of estrogen, we examined the role of estrogen in the regulation of endothelin-1 (ET-1) production by cultured bovine carotid arterial endothelial cells. Treatment of the cells with 17beta-estradiol dose dependently inhibited gene expression and peptide...

journal_title：Biochemical and biophysical research communications

authors： Akishita M,Kozaki K,Eto M,Yoshizumi M,Ishikawa M,Toba K,Orimo H,Ouchi Y

更新日期：1998-10-09 00:00:00

abstract：:Astrocytes, a large population of glial cells, detect neurotransmitters and respond by increasing intracellular Ca2+ concentration ([Ca2+]i) and releasing chemical molecules called gliotransmitters. Recently discovered Ca2+ influx through transient receptor potential ankyrin 1 (TRPA1) channels is reported to cause spo...

journal_title：Biochemical and biophysical research communications

authors： Takizawa M,Harada K,Nakamura K,Tsuboi T

更新日期：2018-07-02 00:00:00

abstract：:Interferon gamma (IFN-gamma) plays an important role in immune response, apoptosis, and anti-tumor activity. Its biological activity depends on expression of IFN-gamma receptor (IFN-gammaR). To address whether increased expression of IFN-gammaR is associated in vivo with a higher biological response by IFN-gamma, we c...

journal_title：Biochemical and biophysical research communications

authors： Nishida Y,Maeda Y,Hara A,Arima T,Kimura E,Yamashita S,Uyama E,Mita S,Uchino M

更新日期：2002-01-25 00:00:00